Trimsulfasol 20/100 mg/ml Solution for Use in Drinking Water for Pigs and Chickens

Severely diseased animals can have a decreased appetite and water consumption. If
necessary, the concentration of the veterinary medicinal product in the drinking water
should be adjusted to make sure that the recommended dosage is being consumed.
However, if the concentration of the veterinary medicinal product is increased too much,
the intake of the medicated drinking water decreases for palatability reasons. Therefore,
water intake should be monitored regularly, especially in broilers.
In case of insufficient uptake of water, pigs should be treated parenterally.

Special precautions for safe use in the target species:
Due to the likely variability (time or geographically) in susceptibility of bacteria for
potentiated sulphonamides, occurrence of resistance of bacteria may differ from country to
country and even from farm to farm, and therefore bacteriological sampling and
susceptibility testing are recommended. Use of the veterinary medicinal product should be
based on identification and susceptibility testing of the target pathogen(s). If this is not
possible, therapy should be based on epidemiological information and knowledge of
susceptibility of the target pathogens at farm level, or at local regional level.
Use of the veterinary medicinal product deviating from the instructions given in the SPC
may increase the prevalence of bacteria resistant to sulfamethoxazole and trimethoprim
and may also decrease the effectiveness of combinations of trimethoprim with other
sulphonamides due to the potential for cross resistance. Use of the veterinary medicinal
product should be in accordance with official, national and regional antimicrobial policies.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Sulphonamides may cause hypersensitivity (allergy) following injection, inhalation,
ingestion or skin contact. Hypersensitivity to sulphonamides may lead to cross reactions
with other antibiotics. Allergic reactions to these substances may occasionally be serious.
People with known hypersensitivity (allergy) to sulphonamides or trimethoprim should
avoid contact with the veterinary medicinal product. If you develop symptoms following
exposure, such as a skin rash, you should seek medical advice and show the package
leaflet or the label to the physician.
This veterinary medicinal product may cause skin- and respiratory irritation as well as eye
damage. During preparation and administration of the medicated drinking water, skin and
eye contact with the drug should be avoided. Personal protective equipment consisting of
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impermeable gloves e.g. rubber or latex and protective glasses should be worn when
handling the veterinary medicinal product.
Avoid inhalation. Wash hands and contaminated skin immediately after handling the
veterinary medicinal product.
In the event of eye contact, rinse the eye with large amounts of clean water and, if irritation
occurs, seek medical attention.
In case of accidental ingestion, seek medical advice immediately and show the package
leaflet or the label to the physician.
Laboratory studies in rabbits and rats with the excipient N-methyl pyrrolidone have shown
evidence of foetotoxic effects. The veterinary medicinal product should not be
administered by pregnant women and women suspected of being pregnant. Personal
protective equipment consisting of gloves should be worn when handling the veterinary
medicinal product by women of childbearing age.
Special precautions for the protection of the environment:
Manure from animals treated with this veterinary medicinal product may cause toxic effects
to plants after spreading onto land. This risk can be reduced by avoiding too frequent and
repeated use of the veterinary medicinal product.