POM-V Prescription Required

Advocin 180, 180 mg/ml, Solution for Injection for Cattle

Active ingredient: Danofloxacin

Form

Injection

Species

Cattle

Manufacturer

Zoetis UK Limited

VMD MA No.

42058/5107

What it's used for

In cattle: Treatment of bovine respiratory disease caused by Mannheimia haemolytica, Pasteurella multocidaHistophilus somni sensitive to danofloxacin. For...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Danofloxacin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Advocin 180, 180 mg/ml, Solution for Injection for Cattle — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

In cattle:
Treatment of bovine respiratory disease caused by Mannheimia haemolytica,
Pasteurella multocidaHistophilus somni sensitive to danofloxacin.
For the treatment of acute bovine mastitis caused by Escherichia coli sensitive to
danofloxacin.
In neo-natal calves:
Treatment of enteric infections caused by Escherichia coli sensitive to danofloxacin.

Revised: October 2023
AN: 01944/2022

Do not use in cases of hypersensitivity to the active substance, to other
(fluoro)quinolones or to any of the excipients.

Cattle:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Anaphylactic shock
In sensitive animals, immediate or delayed.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder <or its local representative> or the national
competent authority via the national reporting system. See also ‘Contact details’ of
the package leaflet.

The safety of the veterinary medicinal product has not been assessed in breeding
bulls.

Special precautions for safe use in the target species:
Use of fluoroquinolones should be based on susceptibility testing and take into
account official and local antimicrobial use policies. It is prudent to reserve
fluoroquinolones for the treatment of clinical conditions which have responded poorly,
or are expected to respond poorly, to other classes of antimicrobials. Efficacy
against gram positive strains has not been established.
For fluoroquinolones as a class, over-dosage at multiples of the recommended dose
has been shown to induce erosion of articular cartilage. Care should be taken to
dose accurately and the veterinary medicinal product should be used with caution in
animals with joint disease or cartilage growth disorders.
Use of the veterinary medicinal product deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to fluoroquinolones and may
decrease the effectiveness of treatment with other quinolones due to the potential for
cross resistance.
Do not use in cases where the pathogen involved is resistant to other
fluoroquinolones (due to the potential for cross resistance).
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
People with known hypersensitivity to (fluoro)quinolones should avoid contact with
the veterinary medicinal product.
Care should be taken to avoid accidental self-injection, it can induce a slight irritation.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
In case of contact with skin or eyes, rinse with plenty of water.
Wash hands after use.
Do not eat, drink or smoke during application.
Special precautions for the protection of the environment:
Not applicable.

Revised: October 2023
AN: 01944/2022

When fluoroquinolones have been combined with bacteriostatic antimicrobials, such
as tetracyclines and macrolides or phenicols, an antagonism was demonstrated in
vitro.

Store in the original package in order to protect from light.
Do not freeze.

Meat and offal: 8 days.
Milk: 4 days.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.