Metaxol 20/100 mg/ml Solution for Use in Drinking Water for Pigs and Chickens

Severely diseased animals can have a decreased appetite and water
consumption. If necessary the concentration of the veterinary medicinal product
in the drinking water should be adjusted to make sure that the recommended
dosage is being consumed. However if the concentration of the veterinary
medicinal product is increased too much, the intake of the medicated drinking
water decreases for palatability reasons. Therefore water intake should be
monitored regularly, especially in broilers.
In case of insufficient intake of water, pigs should be treated parenterally.

Special precautions for use in animals
Due to the likely variability (time, geographical) in susceptibility of bacteria for
potentiated sulphonamides, occurrence of resistance of bacteria may differ from
country to country and even from farm to farm, and therefore bacteriological
sampling and susceptibility testing are recommended. Use of the veterinary
medicinal product should be based on culture and sensitivity of micro-
organisms from diseased cases on farm or from recent previous experience on
the farm. Use of the veterinary medicinal product deviating from the instructions
given in the SPC may increase the prevalence of bacteria resistant to
sulfamethoxazole and trimethoprim and may also decrease the effectiveness of
combinations of trimethoprim with other sulphonamides due to the potential for
cross resistance. Official and local antimicrobial policies should be taken into
account when the veterinary medicinal product is used.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Sulphonamides may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to sulphonamides may
lead to cross reactions with other antibiotics. Allergic reactions to these
substances may occasionally be serious.
Do not handle this veterinary medicinal product if you know you are sensitive to
sulphonamides.
If you develop symptoms following exposure, such as a skin rash, you should
seek medical advice and show the physician this warning.

Revised: May 2024
AN: 00300/2023 and 02321/2023
Laboratory studies in rabbits and rats conducted with the excipient N-methyl
pyrrolidone have shown evidence of foetotoxic effects. The veterinary medicinal
product should not be administered by pregnant women and women suspected
of being pregnant. Personal protective equipment consisting of gloves should
be worn when handling the veterinary medicinal product by women of
childbearing age.
This veterinary medicinal product may cause skin- and respiratory irritation as
well as eye damage.
Impermeable gloves, e.g. rubber or latex and protective glasses, should be
worn when handling the veterinary medicinal product including when mixing the
veterinary medicinal product with drinking water. Avoid inhalation. In the event
of eye contact, rinse the eye with large amounts of clean water and, if irritation
occurs, seek medical attention. In the event of accidental ingestion, seek
medical advice. Wash hands and contaminated skin immediately after handling
the veterinary medicinal product.
Special precautions for the protection of the environment
Not applicable.
Other precautions
Not applicable.