Metaxol 20/100 mg/ml Solution for Use in Drinking Water for Pigs and Chickens

Severely diseased animals can have a decreased appetite and water consumption. If
necessary the concentration of the veterinary medicinal in the drinking water should
be adjusted to make sure that the recommended dosage is being consumed.
However if the concentration of the veterinary medicinal product is increased too
much, the intake of the medicated drinking water decreases for palatability reasons.
Therefore water intake should be monitored regularly, especially in broilers.
In case of insufficient intake of water, pigs should be treated parenterally.

Special precautions for safe use in the target species:
Due to the likely variability (time, geographical) in susceptibility of bacteria for
potentiated sulphonamides, occurrence of resistance of bacteria may differ from
country to country and even from farm to farm, and therefore bacteriological sampling
and susceptibility testing are recommended. Use of the veterinary medicinal product
should be based on culture and sensitivity of micro-organisms from diseased cases
on farm or from recent previous experience on the farm. Use of the veterinary
medicinal product deviating from the instructions given in the SPC may increase the
prevalence of bacteria resistant to sulfamethoxazole and trimethoprim and may also
decrease the effectiveness of combinations of trimethoprim with other sulphonamides
due to the potential for cross resistance. Official and local antimicrobial policies
should be taken into account when the veterinary medicinal product is used.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Sulphonamides may cause hypersensitivity (allergy) following injection, inhalation,
ingestion or skin contact. Hypersensitivity to sulphonamides may lead to cross
reactions with other antibiotics. Allergic reactions to these substances may
occasionally be serious.
Do not handle this veterinary medicinal product if you know you are sensitive to
sulphonamides.
If you develop symptoms following exposure, such as a skin rash, you should seek
medical advice and show the physician this warning.
.
This veterinary medicinal product may cause skin- and respiratory irritation as well as
eye damage.
Personal protective equipment consisting of impermeable gloves, e.g. rubber or latex
and protective glasses, should be worn when handling the veterinary medicinal
AN: 00299/2023 & 02135/2023
product including when mixing the veterinary medicinal product with drinking water.
Avoid inhalation. In the event of eye contact, rinse the eye with large amounts of
clean water and, if irritation occurs, seek medical attention. In the event of accidental
ingestion, seek medical advice and show the package leaflet or the label to the
physician. Wash hands and contaminated skin immediately after handling the
veterinary medicinal product. Laboratory studies in rabbits and rats with the excipient
N-methyl pyrrolidone have shown evidence of foetotoxic effects. The veterinary
medicinal product should not be administered by pregnant women and women
suspected of being pregnant. Personal protective equipment consisting of gloves
should be worn when handling the veterinary medicinal product by women of
childbearing age.
Special precautions for the protection of the environment:
Not applicable.