POM-V
Prescription Required
Vetmulin 450 mg/g Granules for Use in Drinking Water for Pigs, Chickens and Turkeys
Active ingredient: Tiamulin Hydrogen Fumarate
Form
Powder
Species
Chickens
Pigs
Turkeys
Manufacturer
Huvepharma NV
VMD MA No.
30282/4002
What it's used for
veterinary medicinal product is used. Treatment of Porcine Colonic Spirochaetosis (colitis) caused by Brachyspira pilosicoli susceptible to tiamulin. The p...
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Prescription required
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Clinical information
Vetmulin 450 mg/g Granules for Use in Drinking Water for Pigs, Chickens and Turkeys — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
veterinary medicinal product is used.
Treatment of Porcine Colonic Spirochaetosis (colitis) caused by Brachyspira pilosicoli
susceptible to tiamulin. The presence of the disease in the herd must be established
before the veterinary medicinal product is used.
Treatment of Porcine Proliferative Enteropathy (ileitis) caused by Lawsonia
intracellularis susceptible to tiamulin. The presence of the disease in the herd must
be established before the veterinary medicinal product is used.
Treatment and metaphylaxis of Enzootic Pneumonia caused by
hyopneumoniae, including infections complicated by Pasteurella multocida
susceptible to tiamulin. The presence of the disease in the herd must be established
before the veterinary medicinal product is used.
AN: 02196/2024 & 02199/2024
Treatment of Pleuropneumonia caused by Actinobacillus pleuropneumoniae
susceptible to tiamulin. The presence of the disease in the herd must be established
before the veterinary medicinal product is used.
Chickens
Treatment and metaphylaxis of Chronic Respiratory Disease caused by Mycoplasma
gallisepticum and Airsacculitis and Infectious Synovitis caused by Mycoplasma
synoviae susceptible to tiamulin. The presence of the disease in the flock must be
established before the veterinary medicinal product is used.
Turkeys
Treatment and metaphylaxis of Infectious Sinusitis and Airsacculitis caused by
Mycoplasma gallisepticum, Mycoplasma synoviae and Mycoplasma meleagridis
susceptible to tiamulin. The presence of the disease in the herd or flock must be
established before use.
Treatment of Porcine Colonic Spirochaetosis (colitis) caused by Brachyspira pilosicoli
susceptible to tiamulin. The presence of the disease in the herd must be established
before the veterinary medicinal product is used.
Treatment of Porcine Proliferative Enteropathy (ileitis) caused by Lawsonia
intracellularis susceptible to tiamulin. The presence of the disease in the herd must
be established before the veterinary medicinal product is used.
Treatment and metaphylaxis of Enzootic Pneumonia caused by
hyopneumoniae, including infections complicated by Pasteurella multocida
susceptible to tiamulin. The presence of the disease in the herd must be established
before the veterinary medicinal product is used.
AN: 02196/2024 & 02199/2024
Treatment of Pleuropneumonia caused by Actinobacillus pleuropneumoniae
susceptible to tiamulin. The presence of the disease in the herd must be established
before the veterinary medicinal product is used.
Chickens
Treatment and metaphylaxis of Chronic Respiratory Disease caused by Mycoplasma
gallisepticum and Airsacculitis and Infectious Synovitis caused by Mycoplasma
synoviae susceptible to tiamulin. The presence of the disease in the flock must be
established before the veterinary medicinal product is used.
Turkeys
Treatment and metaphylaxis of Infectious Sinusitis and Airsacculitis caused by
Mycoplasma gallisepticum, Mycoplasma synoviae and Mycoplasma meleagridis
susceptible to tiamulin. The presence of the disease in the herd or flock must be
established before use.
When medicating large volumes of water, prepare a concentrated solution first and
then dilute to the required final concentration.
Fresh solutions of tiamulin-medicated drinking water should be made up each day.
To ensure the correct dosage, body weight should be determined as accurately as
possible. The intake of medicated water depends on the clinical condition of the
animals. In order to obtain the correct dosage the concentration of tiamulin may need
to be adjusted accordingly.
In order to avoid interactions between the ionophores and tiamulin, the veterinarian
and farmer should check that the feed label does not state that it contains
salinomycin, monensin and narasin.
For chickens and turkeys, in order to avoid interactions between the incompatible
ionophores monensin, narasin and salinomycin and tiamulin, the feed mill supplying
the birds feed should be notified that tiamulin will be used and that these
anticoccidials should not be included in the feed or contaminate the feed.
AN: 02196/2024 & 02199/2024
The feed should be tested for the ionophores prior to use if there is any suspicion
that contamination of the feed might occur.
If an interaction does occur, stop tiamulin medication immediately and replace with
fresh drinking water. Remove contaminated feed as soon as possible and replace
with feed not containing the tiamulin-incompatible ionophores.
Based on the recommended dose and the number and weight of animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated according to the following formula:
Dose (mg veterinary
medicinal product
per kg body weight per
day
x
Mean body weight (kg)
of animals to be treatedMean daily water consumption (liter) per animal per day’
=....mg veterinary medicinal
product per liter of drinking
water
Chickens:
For the treatment and metaphylaxis of Chronic Respiratory Disease caused by
Mycoplasma gallisepticum and Airsacculitis and Infectious Synovitis caused by
Mycoplasma synoviae.
The dosage is 25 mg tiamulin hydrogen fumarate (equivalent to 55.6 mg of veterinary
medicinal product)/kg body weight administered daily for the period of 3 to 5
consecutive days.
Turkeys:
For the treatment and metaphylaxis of Infectious Sinusitis and Airsacculitis caused by
Mycoplasma gallisepticum, Mycoplasma synoviae and Mycoplasma meleagridis.
The dosage is 40 mg tiamulin hydrogen fumarate (equivalent to 88.9 mg of veterinary
medicinal product)/kg body weight administered daily for the period of 3 to 5
consecutive days.
AN: 02196/2024 & 02199/2024
Pigs:
For the treatment of Swine Dysentery caused by Brachyspira hyodysenteriae
The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 19.6 mg of
veterinary medicinal product)/kg body weight administered daily in the drinking water
of pigs for 3 to 5 consecutive days depending on the severity of the infection and/or
the duration of the disease.
For the treatment of Porcine Colonic Spirochaetosis (colitis) caused by Brachyspira
pilosicoli:
The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 19.6 mg of
veterinary medicinal product)/kg body weight administered daily in the drinking water
of pigs for 3 to 5 consecutive days depending on the severity of the infection and/or
the duration of the disease.
For the treatment of Porcine Proliferative Enteropathy (ileitis) caused by Lawsonia
intracellularis:
The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 19.6 mg of
veterinary medicinal product)/kg body weight administered daily in the drinking water
of pigs for 5 consecutive days.
For the treatment and metaphylaxis of Enzootic Pneumonia caused by Mycoplasma
hyopneumoniae, including infections complicated by Pasteurella multocida
susceptible to tiamulin.
The dosage is 20 mg tiamulin hydrogen fumarate (equivalent to 44.4 mg of veterinary
medicinal product)/kg body weight administered daily for 5 consecutive days.
For the treatment of Pleuropneumonia caused by Actinobacillus pleuropneumoniae
susceptible to tiamulin:
The dosage is 20 mg tiamulin hydrogen fumarate (equivalent to 44.4 mg of veterinary
medicinal product)/kg body weight administered daily for 5 consecutive days.
The use of suitably calibrated weighing equipment is recommended.
The maximum solubility of the veterinary medicinal product is 10 gram/liter.
then dilute to the required final concentration.
Fresh solutions of tiamulin-medicated drinking water should be made up each day.
To ensure the correct dosage, body weight should be determined as accurately as
possible. The intake of medicated water depends on the clinical condition of the
animals. In order to obtain the correct dosage the concentration of tiamulin may need
to be adjusted accordingly.
In order to avoid interactions between the ionophores and tiamulin, the veterinarian
and farmer should check that the feed label does not state that it contains
salinomycin, monensin and narasin.
For chickens and turkeys, in order to avoid interactions between the incompatible
ionophores monensin, narasin and salinomycin and tiamulin, the feed mill supplying
the birds feed should be notified that tiamulin will be used and that these
anticoccidials should not be included in the feed or contaminate the feed.
AN: 02196/2024 & 02199/2024
The feed should be tested for the ionophores prior to use if there is any suspicion
that contamination of the feed might occur.
If an interaction does occur, stop tiamulin medication immediately and replace with
fresh drinking water. Remove contaminated feed as soon as possible and replace
with feed not containing the tiamulin-incompatible ionophores.
Based on the recommended dose and the number and weight of animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated according to the following formula:
Dose (mg veterinary
medicinal product
per kg body weight per
day
x
Mean body weight (kg)
of animals to be treatedMean daily water consumption (liter) per animal per day’
=....mg veterinary medicinal
product per liter of drinking
water
Chickens:
For the treatment and metaphylaxis of Chronic Respiratory Disease caused by
Mycoplasma gallisepticum and Airsacculitis and Infectious Synovitis caused by
Mycoplasma synoviae.
The dosage is 25 mg tiamulin hydrogen fumarate (equivalent to 55.6 mg of veterinary
medicinal product)/kg body weight administered daily for the period of 3 to 5
consecutive days.
Turkeys:
For the treatment and metaphylaxis of Infectious Sinusitis and Airsacculitis caused by
Mycoplasma gallisepticum, Mycoplasma synoviae and Mycoplasma meleagridis.
The dosage is 40 mg tiamulin hydrogen fumarate (equivalent to 88.9 mg of veterinary
medicinal product)/kg body weight administered daily for the period of 3 to 5
consecutive days.
AN: 02196/2024 & 02199/2024
Pigs:
For the treatment of Swine Dysentery caused by Brachyspira hyodysenteriae
The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 19.6 mg of
veterinary medicinal product)/kg body weight administered daily in the drinking water
of pigs for 3 to 5 consecutive days depending on the severity of the infection and/or
the duration of the disease.
For the treatment of Porcine Colonic Spirochaetosis (colitis) caused by Brachyspira
pilosicoli:
The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 19.6 mg of
veterinary medicinal product)/kg body weight administered daily in the drinking water
of pigs for 3 to 5 consecutive days depending on the severity of the infection and/or
the duration of the disease.
For the treatment of Porcine Proliferative Enteropathy (ileitis) caused by Lawsonia
intracellularis:
The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 19.6 mg of
veterinary medicinal product)/kg body weight administered daily in the drinking water
of pigs for 5 consecutive days.
For the treatment and metaphylaxis of Enzootic Pneumonia caused by Mycoplasma
hyopneumoniae, including infections complicated by Pasteurella multocida
susceptible to tiamulin.
The dosage is 20 mg tiamulin hydrogen fumarate (equivalent to 44.4 mg of veterinary
medicinal product)/kg body weight administered daily for 5 consecutive days.
For the treatment of Pleuropneumonia caused by Actinobacillus pleuropneumoniae
susceptible to tiamulin:
The dosage is 20 mg tiamulin hydrogen fumarate (equivalent to 44.4 mg of veterinary
medicinal product)/kg body weight administered daily for 5 consecutive days.
The use of suitably calibrated weighing equipment is recommended.
The maximum solubility of the veterinary medicinal product is 10 gram/liter.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use in pigs and birds that could receive products containing ionophoses such
as monensin, narasin or salinomycin during or for at least seven days before or after
treatment with tiamulin. Severe growth depression or death may result. See section
3.8 for information regarding interaction between tiamulin and ionophores.
excipients.
Do not use in pigs and birds that could receive products containing ionophoses such
as monensin, narasin or salinomycin during or for at least seven days before or after
treatment with tiamulin. Severe growth depression or death may result. See section
3.8 for information regarding interaction between tiamulin and ionophores.
Pigs:
ErythemaVery rare
(<1 animal / 10.00000 animals treated,
including isolated report(s)):
Skin oedema
1
mild
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
ErythemaVery rare
(<1 animal / 10.00000 animals treated,
including isolated report(s)):
Skin oedema
1
mild
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Animals with reduced water intake and/or in a debilitated condition should be treated
parenterally.
Water intake may be depressed during the administration of tiamulin in birds. It
appears to be concentration-dependent with 500 mg tiamulin hydrogen fumarate
(equivalent to 1.11 g of veterinary medicinal product) in 4 litres of water reducing
intake by approximately 10% and 500 mg tiamulin hydrogen fumarate (equivalent to
1.11 g of veterinary medicinal product) in 2 litres of water by 15% in chickens. It does
not appear to have any adverse effect on overall performance of the birds or efficacy
of the veterinary medicinal product but water intake should be monitored at frequent
intervals, especially in hot weather. In turkeys, it is more marked, with approximately
20% reduction and therefore it is recommended not to exceed a concentration of 500
mg tiamulin hydrogen fumarate in 2 litres of the drinking water
Repeated use should be avoided by improving management practice and thorough
cleansing and disinfection.
Special precautions for safe use in the target species:
Use of the veterinary medicinal product should be based on susceptibility testing of
the bacteria isolated from the animal. If this is not possible, therapy should be based
on local (regional, farm level) epidemiological information about susceptibility of
target bacteria.
Inappropriate use of the veterinary medicinal product may increase the prevalence of
bacteria resistant to tiamulin.
AN: 02196/2024 & 02199/2024
Special precautions for the person administering the veterinary medicinal product to
animals:
Direct contact with the skin, eyes and mucous membranes and inhalation of dust
should be avoided. Personal protective equipment consisting of overalls,
impermeable rubber gloves, safety glasses and a disposable half-mask respirator
conforming to European Standard EN 149 or a non-disposable respirator to
European Standard EN 140 with a filter to EN 143 should be worn when handling the
veterinary medicinal product.
In case of accidental eye contact, rinse the eyes thoroughly with clean running water
immediately. Seek medical advice if irritation persists and show the package leaflet
or the label to the physician.
Contaminated clothing should be removed and any splashes on to the skin should be
washed off immediately.
Wash hands after use.
Accidental ingestion should be avoided. In case of accidental ingestion, seek
medical advice immediately and show the package leaflet or the label to the
physician.
People with known hypersensitivity to tiamulin should avoid contact with the
veterinary medicinal product.
Special precautions for the protection of the environment
Not applicable.
parenterally.
Water intake may be depressed during the administration of tiamulin in birds. It
appears to be concentration-dependent with 500 mg tiamulin hydrogen fumarate
(equivalent to 1.11 g of veterinary medicinal product) in 4 litres of water reducing
intake by approximately 10% and 500 mg tiamulin hydrogen fumarate (equivalent to
1.11 g of veterinary medicinal product) in 2 litres of water by 15% in chickens. It does
not appear to have any adverse effect on overall performance of the birds or efficacy
of the veterinary medicinal product but water intake should be monitored at frequent
intervals, especially in hot weather. In turkeys, it is more marked, with approximately
20% reduction and therefore it is recommended not to exceed a concentration of 500
mg tiamulin hydrogen fumarate in 2 litres of the drinking water
Repeated use should be avoided by improving management practice and thorough
cleansing and disinfection.
Special precautions for safe use in the target species:
Use of the veterinary medicinal product should be based on susceptibility testing of
the bacteria isolated from the animal. If this is not possible, therapy should be based
on local (regional, farm level) epidemiological information about susceptibility of
target bacteria.
Inappropriate use of the veterinary medicinal product may increase the prevalence of
bacteria resistant to tiamulin.
AN: 02196/2024 & 02199/2024
Special precautions for the person administering the veterinary medicinal product to
animals:
Direct contact with the skin, eyes and mucous membranes and inhalation of dust
should be avoided. Personal protective equipment consisting of overalls,
impermeable rubber gloves, safety glasses and a disposable half-mask respirator
conforming to European Standard EN 149 or a non-disposable respirator to
European Standard EN 140 with a filter to EN 143 should be worn when handling the
veterinary medicinal product.
In case of accidental eye contact, rinse the eyes thoroughly with clean running water
immediately. Seek medical advice if irritation persists and show the package leaflet
or the label to the physician.
Contaminated clothing should be removed and any splashes on to the skin should be
washed off immediately.
Wash hands after use.
Accidental ingestion should be avoided. In case of accidental ingestion, seek
medical advice immediately and show the package leaflet or the label to the
physician.
People with known hypersensitivity to tiamulin should avoid contact with the
veterinary medicinal product.
Special precautions for the protection of the environment
Not applicable.
Tiamulin has been shown to interact with ionophores such as monensin, salinomycin
and narasin and may result in signs indistinguishable from an ionophore toxicosis.
Animals should not receive products containing monensin, salinomycin or narasin
during or at least 7 days before or after treatment with tiamulin. Severe growth
depression, ataxia, paralysis or death may result.
If signs of an interaction do occur, stop both the administration of tiamulin-medicated
drinking water and also the administration of ionophore-contaminated feed
immediately. The feed should be removed and replaced with fresh feed not
containing the anticoccidials monensin, salinomycin or narasin.
Concomitant use of tiamulin and the divalent ionophore anticoccidials lasalocid and
semduramicin do not appear to cause any interaction, however the concomitant use
of maduramicin may lead to a mild to moderate growth depression in chickens. The
situation is transient and recovery normally occurs within 3-5 days following
withdrawal of tiamulin treatment.
and narasin and may result in signs indistinguishable from an ionophore toxicosis.
Animals should not receive products containing monensin, salinomycin or narasin
during or at least 7 days before or after treatment with tiamulin. Severe growth
depression, ataxia, paralysis or death may result.
If signs of an interaction do occur, stop both the administration of tiamulin-medicated
drinking water and also the administration of ionophore-contaminated feed
immediately. The feed should be removed and replaced with fresh feed not
containing the anticoccidials monensin, salinomycin or narasin.
Concomitant use of tiamulin and the divalent ionophore anticoccidials lasalocid and
semduramicin do not appear to cause any interaction, however the concomitant use
of maduramicin may lead to a mild to moderate growth depression in chickens. The
situation is transient and recovery normally occurs within 3-5 days following
withdrawal of tiamulin treatment.
Do not refrigerate or freeze.
Store in original container.
Store in original container.
Pigs
Meat and offal: 2 days (8.8 mg tiamulin hydrogen fumarate (equivalent to 19.6 mg of
veterinary medicinal product)/kg body weight)
Meat and offal: 4 days (20 mg tiamulin hydrogen fumarate (equivalent to 4
Meat and offal: 2 days (8.8 mg tiamulin hydrogen fumarate (equivalent to 19.6 mg of
veterinary medicinal product)/kg body weight)
Meat and offal: 4 days (20 mg tiamulin hydrogen fumarate (equivalent to 4
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Same active ingredient
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