Denagard 12.5% w/v Concentrate for Oral Solution

Pigs:
The dosage is 8.8 mg of the active substance per kg bodyweight daily, (equivalent to
10 ml solution per 142 kg bodyweight) administered in the drinking water of pigs for
3 to 5 days, depending on the severity of the infection and/or the duration of the
disease.
The contents of each 250 ml bottle will treat 46 pigs of 25 kg bodyweight for 3 days
or 28 pigs of 25 kg bodyweight for 5 days.
The contents of each 1 litre bottle will treat 188 pigs of 25 kg bodyweight for 3 days
or 114 pigs of 25 kg bodyweight for 5 days.
To ensure an intake of 8.8 mg/kg daily, the product may be administered in one of
two ways:
i) Administer in approximately one half of the daily water requirements, to
ensure consumption of the correct dose. Unmedicated water should be
provided each day after the medicated water has been consumed. The
dosage rate, calculated on a liveweight basis, is equivalent to 10 ml
solution per 142 kg bodyweight.
ii) Administer continuously at a level of 60 ppm of active substance in the
drinking water, as the only source of drinking water. The daily requirement
should be added to the drinking water at the rate of 9.6 ml Solution per 20
litres (4.5 gallons) of water.
Where a water medicator is used the appropriate stock solution should always be
made up according to the maker's instructions.
If there is no response to treatment within 5 days, the diagnosis should be re-
established.
Chickens:
The dosage for chickens is 25 mg of active substance per kg bodyweight (equivalent
to 100 ml solution per 500 kg bodyweight). Tiamulin should be administered at
0.025% in drinking water (2 ml product per litre of water) for 3 – 5 days and will
provide approximately the following daily dosage of tiamulin depending on the age of
the bird.
Day old chick: 125 – 150 mg/kg bodyweight
4 week old broiler: 30 – 50 mg/kg bodyweight
10 week old pullet: 30 – 45 mg/kg bodyweight
Layer: 25 mg/kg bodyweight

Revised: December 2025
MA split from NI Expiry following AN: 02098/2025
Turkeys:
The dosage for turkeys is 25 mg of active substance per kg bodyweight
to 100 ml solution per 500 kg bodyweight). Tiamulin should be administered at
0.025% in drinking water (2 ml product per litre of water) for 5 days and will provide
approximately the following daily dosage of tiamulin depending on the age of the bird.
1 week old poult: 70 mg/kg bodyweight
4 week old poult: 50 mg/kg bodyweight
8 week old poult: 20 – 30 mg/kg bodyweight
20 week old poult: 25 mg/kg bodyweight
Monitor water intake at frequent intervals during medication.
Fresh solutions of tiamulin-medicated drinking water should be made up each day.