Tialin 125 mg/ml Solution for Use in Drinking Water for Pigs, Chickens and Turkeys

The veterinary medicinal product should be administered using suitably calibrated
equipment.
Guidance for preparing veterinary medicinal product solutions:
When medicating large volumes of water, prepare a concentrated solution first and
then dilute to the required final concentration.
The veterinary medicinal product is soluble and stable from low concentration up to
maximum concentration of the veterinary medicinal product of 500 ml/L (1:2 dilution)
in water of at least 4° C.
Fresh solutions of tiamulin-medicated drinking water should be made up each day.
Any medicated drinking water remaining from the previous day should be discarded.
To ensure a correct dosage, body weight should be determined as accurately as
possible to avoid underdosing. The intake of medicated water depends on the clinical
condition of the animals. In order to obtain the correct dosage the concentration of
tiamulin has to be adjusted accordingly.
Make sure the animals do not have access to non-medicated water during the period
when the medicated water is given.
After the end of the medication period the water supply system should be cleaned
appropriately to avoid intake of sub-therapeutic amounts of the active substance.
In order to avoid interactions between the ionophores and tiamulin, the veterinarian
and farmer should check that the feed label does not state that it contains
salinomycin, monensin or narasin.
For chickens and turkeys, in order to avoid interactions between the incompatible
ionophores monensin, narasin or salinomycin and tiamulin, the feed mill supplying
the birds’ feed should be notified that tiamulin will be used and that these
anticoccidials should not be included in the feed or contaminate the feed.
The feed should be tested for the ionophores prior to use if there is any suspicion
that contamination of the feed might occur.
If an interaction does occur, stop tiamulin medication immediately and replace with
fresh drinking water. Remove contaminated feed as soon as possible and replace
with feed not containing the tiamulin-incompatible ionophores.
Based on the recommended dose and the number and weight of animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated according to the following formula:
Dose (ml veterinary
medicinal product per kg
body weight per day)
X
Mean body weight (kg)
of animals to be treated
Mean daily water consumption (litre) per animal per day
= ___ ml veterinary
medicinal product per
litre of drinking water
Pigs
i) For the treatment of Swine Dysentery caused by Brachyspira hyodysenteriae
The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 0.07 ml solution)/kg
body weight administered daily in the drinking water of pigs for 3 to 5 consecutive
days depending on the severity of the infection and/or the duration of the disease.
ii) For the treatment of Porcine Colonic Spirochaetosis (colitis) caused by Brachyspira
pilosicoli.
The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 0.07 ml solution)/kg
body weight administered daily in the drinking water of pigs for 3 to 5 consecutive
days depending on the severity of the infection and/or the duration of the disease.
iii) For the treatment of Porcine Proliferative Enteropathy (ileitis) caused by
intracellularis.
The dosage is 8.8 mg tiamulin hydrogen fumarate (equivalent to 0.07 ml solution)/kg
body weight administered daily in the drinking water of pigs for 5 consecutive days.
iv) For the treatment and metaphylaxis of Enzootic Pneumonia caused by
Mycoplasma hyopneumoniae, including infections complicated by Pasteurella
multocida susceptible to tiamulin.
The dosage is 20 mg tiamulin hydrogen fumarate (equivalent to 0.16 ml solution)/kg
body weight administered daily for 5 consecutive days.
v) For the treatment of Pleuropneumonia caused by Actinobacillus pleuropneumoniae
susceptible to tiamulin.
The dosage is 20 mg tiamulin hydrogen fumarate (equivalent to 0.16 ml solution)/kg
body weight administered daily for 5 consecutive days.
Chickens
For the treatment and metaphylaxis of Chronic Respiratory Disease caused by
Mycoplasma gallisepticum and Airsacculitis and Infectious Synovitis caused by
Mycoplasma synoviae.
The dosage is 25 mg tiamulin hydrogen fumarate (equivalent to 0.2 ml solution)/kg
body weight administered daily for the period of 3 to 5 consecutive days.
Turkeys
For the treatment and metaphylaxis of Infectious Sinusitis and Airsacculitis caused by
Mycoplasma gallisepticum, Mycoplasma synoviae and Mycoplasma meleagridis.
The dosage is 40 mg tiamulin hydrogen fumarate (equivalent to 0.32 ml solution)/kg
body weight administered daily for the period of 3 to 5 consecutive days.