Vetmulin 125 mg/ml Solution for Use in Drinking Water for Pigs and Chickens

Guidance for preparing veterinary medicinal product solutions:
To ensure a correct dosage, body weight should be determined as accurately as
possible. The intake of medicated water depends on the clinical condition of the
animals. In order to obtain the correct dosage, the concentration of tiamulin may
need to be adjusted accordingly.
Based on the recommended dose and the number and weight of animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated according to the following formula:
ml veterinary average body weight (kg)
medicinal product/ x of animals to be treated
kg body weight per day ml veterinary medicinal product
------------------------------------------------------------------------- = per litre of drinking water
average daily water intake (l/animal)
Use a sufficiently accurate commercially available device to measure the required
amount of veterinary medicinal product. Only use clean containers for preparation
of the medicated drinking water. Stir the medicated drinking water prepared with
the veterinary medicinal product for at least 1 minute after preparation in order to
assure homogeneity.
When medicating large volumes of water, prepare a concentrated solution first
and then dilute to the required final concentration. The maximum solubility of the
veterinary medicinal product is 200 mL/L.
Medicated drinking water should be refreshed or replaced every 24 hours.
In order to avoid interactions between the ionophores and tiamulin, the
veterinarian and farmer should check that the feed label does not state that it
contains salinomycin, monensin and narasin.
For chickens, in order to avoid interactions between the incompatible ionophores
monensin, narasin and salinomycin and tiamulin, the feed mill supplying the birds
feed should be notified that tiamulin will be used and that these anticoccidials
should not be included in the feed or contaminate the feed.
The feed should be tested for the ionophores prior to use if there is any suspicion
that contamination of the feed might occur.
If an interaction does occur, stop tiamulin medication immediately and replace
with fresh drinking water. Remove contaminated feed as soon as possible and
replace with feed not containing the tiamulin- incompatible ionophores.
Pigs
i) For the treatment of Swine Dysentery caused by
The dosage is 8.8 mg tiamulin hydrogen fumarate/kg body weight (equivalent to 7
ml of veterinary medicinal product/100 kg body weight) administered daily in the
drinking water of pigs for 3 to 5 consecutive days depending on the severity of the
infection and/or the duration of the disease.
ii) For the treatment of Porcine Colonic Spirochaetosis (colitis) caused by
pilosicoli
(equivalent to 7 ml of veterinary medicinal product/100 kg body weight)
administered daily in the drinking water of pigs for 3 to 5 consecutive days
depending on the severity of the infection and/or the duration of the disease.
iii) For the treatment of Porcine Proliferative Enteropathy (ileitis) caused by
intracellularis
(equivalent to 7 ml of veterinary medicinal product/100 kg body weight)
administered daily in the drinking water of pigs for 5 consecutive days.
iv) For the treatment and metaphylaxis of Enzootic Pneumonia caused by
Mycoplasma hyopneumoniae,
multocida
fumarate/kg body weight (equivalent to 16 ml of veterinary medicinal product/100
kg body weight) administered daily for 5 consecutive days.
Chickens (layer hens)
For the treatment and metaphylaxis of Chronic Respiratory Disease caused by
Mycoplasma gallisepticum
Mycoplasma synoviae
weight (equivalent to 20 ml of veterinary medicinal product/100 kg body weight)
administered daily for the period of 3 to 5 consecutive days.