POM-V
Prescription Required
Vetmulin 100 mg/g Oral Granules for Pigs
Active ingredient: Tiamulin Hydrogen Fumarate
Form
Powder
Species
Pigs
Manufacturer
Huvepharma N.V.
VMD MA No.
30282/4016
What it's used for
Pig For the treatment and metaphylaxis, when the disease is present in the group, of swine dysentery caused by Brachyspira hyodysenteriae susceptible to ti...
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Clinical information
Vetmulin 100 mg/g Oral Granules for Pigs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Pig
For the treatment and metaphylaxis, when the disease is present in the group,
of swine dysentery caused by Brachyspira hyodysenteriae susceptible to
tiamulin. The presence of the disease in the group must be established before
the product is used.
For the treatment of colitis caused by .
For the treatment of ileitis caused by Lawsonia intracellularis.
For the treatment of enzootic pneumonia caused by Mycoplasma
hyopneumoniae.
Chicken
For the treatment and prevention of chronic respiratory disease (CRD) and air
sacculitis caused by Mycoplasma gallisepticum and Mycoplasma synoviae.
Turkey
For the treatment and prevention of infectious sinusitis and air sacculitis
caused by , Mycoplasma meleagridis and
Mycoplasma synoviae.
Revised: December 2025
MA split from NI Expiry following AN: 02282/2025
Rabbit
For the treatment and prevention of epizootic rabbit enterocolitis (ERE) (see
section 4.9 for further information regarding indications).
For the treatment and metaphylaxis, when the disease is present in the group,
of swine dysentery caused by Brachyspira hyodysenteriae susceptible to
tiamulin. The presence of the disease in the group must be established before
the product is used.
For the treatment of colitis caused by .
For the treatment of ileitis caused by Lawsonia intracellularis.
For the treatment of enzootic pneumonia caused by Mycoplasma
hyopneumoniae.
Chicken
For the treatment and prevention of chronic respiratory disease (CRD) and air
sacculitis caused by Mycoplasma gallisepticum and Mycoplasma synoviae.
Turkey
For the treatment and prevention of infectious sinusitis and air sacculitis
caused by , Mycoplasma meleagridis and
Mycoplasma synoviae.
Revised: December 2025
MA split from NI Expiry following AN: 02282/2025
Rabbit
For the treatment and prevention of epizootic rabbit enterocolitis (ERE) (see
section 4.9 for further information regarding indications).
The normal dose is 8.8 mg tiamulin hydrogen fumarate (equivalent to 7.1mg tiamulin
base) per kg bodyweight per day during 7-10 consecutive days. Considering a feed
intake of 50 grams per kg BW, this dose can be achieved by mixing 1.75 g p
veterinary medicinal product into 1 kg of feed (175 ppm).
AN: 02194/2024 & 02195/2024
Examples of g of veterinary medicinal product per animal
BW of animal
Gram of veterinary
medicinal product /animal
201.8252.2302.6353.1403.5454.0504.4605.3706.2807.0907.91008.812511.015013.2
The veterinary medicinal product should be administered to small quantities of feed
for immediate consumption by individual animals. Pigs to be treated should be
separated and treated individually. For treatment of larger groups, it is recommended
to use tiamulin medicated premix for feeding stuff.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
In case of an altered feed intake (weight class, age, environment) adjust the
incorporation in order to guarantee an intake of 8.8 mg tiamulin hydrogen fumarate
per kg per day.
In order to achieve a homogeneous intake it is recommended to use a premixture.
The required amount of veterinary medicinal product can first be mixed with 10 % of
the intended volume of feed. This premixture should then further be mixed
homogeneously with the feed. Alternatively the veterinary medicinal product can be
mixed thoroughly into a part of the daily feed ratio and this can be administered prior
to the feeding. It has to be ensured, that the calculated dose is completely taken up
by the animals. Consideration must be given to pigs whose daily feed intake is
reduced or restricted
The use of suitably calibrated measuring equipment is recommended. The veterinary
medicinal product should only be added to dry non-pelleted feed.
If animals don’t recover within 3 days after oral medication, diagnosis should be
reconsidered and treatment should be changed, if necessary
AN: 02194/2024 & 02195/2024
The treated feed must be prepared daily just before administration to the animals.
base) per kg bodyweight per day during 7-10 consecutive days. Considering a feed
intake of 50 grams per kg BW, this dose can be achieved by mixing 1.75 g p
veterinary medicinal product into 1 kg of feed (175 ppm).
AN: 02194/2024 & 02195/2024
Examples of g of veterinary medicinal product per animal
BW of animal
Gram of veterinary
medicinal product /animal
201.8252.2302.6353.1403.5454.0504.4605.3706.2807.0907.91008.812511.015013.2
The veterinary medicinal product should be administered to small quantities of feed
for immediate consumption by individual animals. Pigs to be treated should be
separated and treated individually. For treatment of larger groups, it is recommended
to use tiamulin medicated premix for feeding stuff.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
In case of an altered feed intake (weight class, age, environment) adjust the
incorporation in order to guarantee an intake of 8.8 mg tiamulin hydrogen fumarate
per kg per day.
In order to achieve a homogeneous intake it is recommended to use a premixture.
The required amount of veterinary medicinal product can first be mixed with 10 % of
the intended volume of feed. This premixture should then further be mixed
homogeneously with the feed. Alternatively the veterinary medicinal product can be
mixed thoroughly into a part of the daily feed ratio and this can be administered prior
to the feeding. It has to be ensured, that the calculated dose is completely taken up
by the animals. Consideration must be given to pigs whose daily feed intake is
reduced or restricted
The use of suitably calibrated measuring equipment is recommended. The veterinary
medicinal product should only be added to dry non-pelleted feed.
If animals don’t recover within 3 days after oral medication, diagnosis should be
reconsidered and treatment should be changed, if necessary
AN: 02194/2024 & 02195/2024
The treated feed must be prepared daily just before administration to the animals.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients
Do not administer products containing ionophores such as monensin, salinomycin or
narasin during or for at least seven days before or after treatment with the veterinary
medicinal product.
Severe growth depression or death may result.
AN: 02194/2024 & 02195/2024
excipients
Do not administer products containing ionophores such as monensin, salinomycin or
narasin during or for at least seven days before or after treatment with the veterinary
medicinal product.
Severe growth depression or death may result.
AN: 02194/2024 & 02195/2024
Pigs
Hypersensitivity reaction (e.g.
dermatitis
, erythema and
intense pruritus
)
.
Rare
(1 to 10 animals /
10,000 animals
treated):
skin oedema
2,4
Acute
Intense
If these typical side effects occur, stop treatment immediately and clean animals
and pens with water. Normally, affected animals recover quickly. Symptomatic
treatment such as electrolyte therapy and an anti-inflammatory therapy may be
useful.
mild
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Hypersensitivity reaction (e.g.
dermatitis
, erythema and
intense pruritus
)
.
Rare
(1 to 10 animals /
10,000 animals
treated):
skin oedema
2,4
Acute
Intense
If these typical side effects occur, stop treatment immediately and clean animals
and pens with water. Normally, affected animals recover quickly. Symptomatic
treatment such as electrolyte therapy and an anti-inflammatory therapy may be
useful.
mild
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
The uptake of medication by animals can be altered as a consequence of illness. For
animals with a reduced feed intake, treat parenterally using an appropriate injectable
veterinary medicinal product.
Long term or repeated use should be avoided by improving management practice
and thorough cleansing and disinfection.
Special precautions for safe use in the target species:
Do not use the veterinary medicinal product in liquid feed.
Due to the likely variability (time, geographical) in the occurrence of resistance of
bacteria for tiamulin, the use of the veterinary medicinal product should be based on
bacteriological sampling and susceptibility testing and take into account official and
local antimicrobial policies.
Use of the veterinary medicinal product deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to tiamulin and may decrease
the effectiveness of treatment with other pleuromutilins due to the potential for cross-
resistance.
If there is no response to treatment within 3 days, the diagnosis should be re-
established.
Avoid concurrent administration of tiamulin and the ionophore products monensin,
narasin and salinomycin (see section 4.8). Inform the feed supplier that tiamulin will
be used, to avoid incorporating the above listed products in the feed and to avoid
contamination of the feed. In case of a suspected contamination, test the feed for the
presence of these ionophores before feeding. If adverse effects occur due to an
interaction, stop administration of the feed immediately. Remove the contaminated
feed as soon as possible and replace with uncontaminated feed.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Direct contact with the skin, eyes, mucous membranes and inhalation of dust should
be avoided. Personal protective equipment consisting of overalls, impermeable
rubber gloves, safety glasses and a disposable half-mask respirator conforming to
European Standard EN 149 or a non-disposable respirator to European Standard
EN 140 with a filter to EN 143 should be worn when handling the veterinary medicinal
product.
Contaminated clothing should be removed and any splashes on to the skin should be
washed off immediately.
In case of accidental eye contact, irrigate the eyes thoroughly with clean running
water immediately. If irritation persists, seek medical advice immediately and show
the package leaflet or the label to the physician.
Accidental ingestion should be avoided. In case of accidental ingestion, seek medical
advice immediately and show the package leaflet or the label to the physician.
Wash hands after use.
People with known hypersensitivity to tiamulin should avoid contact with the
veterinary medicinal product.
AN: 02194/2024 & 02195/2024
Special precautions for the protection of the environment
Not applicable.
animals with a reduced feed intake, treat parenterally using an appropriate injectable
veterinary medicinal product.
Long term or repeated use should be avoided by improving management practice
and thorough cleansing and disinfection.
Special precautions for safe use in the target species:
Do not use the veterinary medicinal product in liquid feed.
Due to the likely variability (time, geographical) in the occurrence of resistance of
bacteria for tiamulin, the use of the veterinary medicinal product should be based on
bacteriological sampling and susceptibility testing and take into account official and
local antimicrobial policies.
Use of the veterinary medicinal product deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to tiamulin and may decrease
the effectiveness of treatment with other pleuromutilins due to the potential for cross-
resistance.
If there is no response to treatment within 3 days, the diagnosis should be re-
established.
Avoid concurrent administration of tiamulin and the ionophore products monensin,
narasin and salinomycin (see section 4.8). Inform the feed supplier that tiamulin will
be used, to avoid incorporating the above listed products in the feed and to avoid
contamination of the feed. In case of a suspected contamination, test the feed for the
presence of these ionophores before feeding. If adverse effects occur due to an
interaction, stop administration of the feed immediately. Remove the contaminated
feed as soon as possible and replace with uncontaminated feed.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Direct contact with the skin, eyes, mucous membranes and inhalation of dust should
be avoided. Personal protective equipment consisting of overalls, impermeable
rubber gloves, safety glasses and a disposable half-mask respirator conforming to
European Standard EN 149 or a non-disposable respirator to European Standard
EN 140 with a filter to EN 143 should be worn when handling the veterinary medicinal
product.
Contaminated clothing should be removed and any splashes on to the skin should be
washed off immediately.
In case of accidental eye contact, irrigate the eyes thoroughly with clean running
water immediately. If irritation persists, seek medical advice immediately and show
the package leaflet or the label to the physician.
Accidental ingestion should be avoided. In case of accidental ingestion, seek medical
advice immediately and show the package leaflet or the label to the physician.
Wash hands after use.
People with known hypersensitivity to tiamulin should avoid contact with the
veterinary medicinal product.
AN: 02194/2024 & 02195/2024
Special precautions for the protection of the environment
Not applicable.
Tiamulin is known to produce clinically important (often lethal) interactions with
ionophore antibiotics, including monensin, narasin, salinomycin. Therefore, pigs
should not receive products containing such compounds during or for at least seven
days before or after treatment with this veterinary medicinal product. Severe growth
depression or death may result.
Tiamulin may lessen the antibacterial activity of beta-lactam antibiotics, whose action
is dependent on bacterial growth.
ionophore antibiotics, including monensin, narasin, salinomycin. Therefore, pigs
should not receive products containing such compounds during or for at least seven
days before or after treatment with this veterinary medicinal product. Severe growth
depression or death may result.
Tiamulin may lessen the antibacterial activity of beta-lactam antibiotics, whose action
is dependent on bacterial growth.
Store below 25°C. Store in a dry place. Protect from direct sunlight.
Store in the original container.
Store in the original container.
The veterinary medicinal product should be administered to small quantities of feed
for immediate consumption by individual animals. Pigs to be treated should be
separated and treated individually. For treatment of larger groups, it is recommended
to use tiamulin medicated premix for feeding stuff.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
In case of an altered feed intake (weight class, age, environment) adjust the
incorporation in order to guarantee an intake of 8.8 mg tiamulin hydrogen fumarate
per kg per day.
In order to achieve a homogeneous intake it is recommended to use a premixture.
The required amount of veterinary medicinal product can first be mixed with 10 % of
the intended volume of feed. This premixture should then further be mixed
homogeneously with the feed. Alternatively the veterinary medicinal product can be
mixed thoroughly into a part of the daily feed ratio and this can be administered prior
to the feeding. It has to be ensured, that the calculated dose is completely taken up
by the animals. Consideration must be given to pigs whose daily feed intake is
reduced or restricted
The use of suitably calibrated measuring equipment is recommended. The veterinary
medicinal product should only be added to dry non-pelleted feed.
If animals don’t recover within 3 days after oral medication, diagnosis should be
reconsidered and treatment should be changed, if necessary
AN: 02194/2024 & 02195/2024
The treated feed must be prepared daily just before administration to the animals.
3.10 Symptoms of overdose (and where applicable, emergency procedures and
antidotes)
A single oral dose of 100 mg/kg BW caused hyperpnoea and abdominal complaints
in pigs. At a dose of 150 mg/kg the only effect on the central nerve system was
lethargy. A dose of 55 mg/kg during 14 days caused increased salivation and a mild
irritation of the stomach. Tiamulin hydrogen fumarate has a relatively high therapeutic
index in pigs. The minimum lethal dose has not been established in pigs.
3.11 Special restrictions for use and special conditions for use, including
restrictions on the use of antimicrobial and antiparasitic veterinary
medicinal products in order to limit the risk of development of resistance
Not applicable.
3.12 Withdrawal periods
Meat and offal: 7 days
4.
for immediate consumption by individual animals. Pigs to be treated should be
separated and treated individually. For treatment of larger groups, it is recommended
to use tiamulin medicated premix for feeding stuff.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
In case of an altered feed intake (weight class, age, environment) adjust the
incorporation in order to guarantee an intake of 8.8 mg tiamulin hydrogen fumarate
per kg per day.
In order to achieve a homogeneous intake it is recommended to use a premixture.
The required amount of veterinary medicinal product can first be mixed with 10 % of
the intended volume of feed. This premixture should then further be mixed
homogeneously with the feed. Alternatively the veterinary medicinal product can be
mixed thoroughly into a part of the daily feed ratio and this can be administered prior
to the feeding. It has to be ensured, that the calculated dose is completely taken up
by the animals. Consideration must be given to pigs whose daily feed intake is
reduced or restricted
The use of suitably calibrated measuring equipment is recommended. The veterinary
medicinal product should only be added to dry non-pelleted feed.
If animals don’t recover within 3 days after oral medication, diagnosis should be
reconsidered and treatment should be changed, if necessary
AN: 02194/2024 & 02195/2024
The treated feed must be prepared daily just before administration to the animals.
3.10 Symptoms of overdose (and where applicable, emergency procedures and
antidotes)
A single oral dose of 100 mg/kg BW caused hyperpnoea and abdominal complaints
in pigs. At a dose of 150 mg/kg the only effect on the central nerve system was
lethargy. A dose of 55 mg/kg during 14 days caused increased salivation and a mild
irritation of the stomach. Tiamulin hydrogen fumarate has a relatively high therapeutic
index in pigs. The minimum lethal dose has not been established in pigs.
3.11 Special restrictions for use and special conditions for use, including
restrictions on the use of antimicrobial and antiparasitic veterinary
medicinal products in order to limit the risk of development of resistance
Not applicable.
3.12 Withdrawal periods
Meat and offal: 7 days
4.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Same active ingredient
Other Products Containing Tiamulin Hydrogen Fumarate
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Denagard 10% w/w Premix for Medicated Feeding Stuff for Pigs, Chickens, Turkeys and Rabbits
POM-VElanco Europe Ltd
premix
Chickens
Pigs
Rabbits
Denagard 12.5% w/v Concentrate for Oral Solution
POM-VElanco Europe Ltd
liquid
Chickens
Pigs
Turkeys
Denagard 200 mg/ml Solution for Injection
POM-VElanco GmbH
injection
Pigs
Denagard 200 mg/ml Solution for Injection
POM-VElanco GmbH
injection
Pigs
Tialin 125 mg/ml Solution for Use in Drinking Water for Pigs, Chickens and Turkeys
POM-VDechra Regulatory B.V.
solution
Chickens
Pigs
Turkeys
Tialin 125 mg/ml Solution for Use in Drinking Water for Pigs, Chickens and Turkeys
POM-VDechra Regulatory B.V.
solution
Chickens
Pigs
Turkeys
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