Ubropen 600 mg Intramammary Suspension for Lactating Cows

phase), because it could select for antimicrobial-resistant bacteria within the intestinal
microbiota of the calf and increase the faecal shedding of these bacteria.
The cleaning towel should not be used in presence of teat injuries.
Care must be taken when applying the product in case of severe udder quarter
swelling, milk duct swelling and/or congestion of detritus in the milk duct.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Penicillins and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may lead
to cross reactions to cephalosporins and vice versa. Allergic reactions to these
substances may occasionally be serious.
•
if you have been advised not to work with such preparations.
•
recommended precautions.
•
wear appropriate disposable gloves. Avoid contact with the eyes. Wash
exposed skin after use. In case of eye contact, wash the eyes thoroughly
with copious amounts of clean running water.
•
medical advice immediately and show the package leaflet or the label to
the physician. Swelling of the face, lips or eyes or difficulty with breathing,
are more serious symptoms and require urgent medical attention.

Revised October 2025
AN: 03744/2024 & 03743/2024
The cleaning towels provided contain isopropyl alcohol, which may be irritating to
skin and eyes. It is recommended that disposable gloves are also worn when using
the cleaning towels.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.
3.6 Adverse events
Cattle:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Hypersensitive reaction, anaphylactic shock,
allergic oedema, urticaria, angioedema, erythema.
In case adverse reactions occur, the current treatment should be withdrawn, and
symptomatic treatment should be initiated.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
3.7 Use during pregnancy, lactation or lay
Can be used during pregnancy, but not during the dry period.
3.8 Interaction with other medicinal products and other forms of interaction
Do not combine with bacteriostatic agents. Tetracyclines, macrolides,
sulphonamides, lincomycin or tiamulin may inhibit the antibacterial effect of penicillins
because of the rapid onset of bacteriostatic action.
3.9 Administration routes and dosage
Intramammary use.
Infuse the contents of one intramammary syringe (equivalent to 600 mg
benzylpenicillin procaine monohydrate) per affected udder quarter once daily after
milking. The treatment is continued for 3-5 days.
Parenteral therapy may also be required depending upon the clinical presentation.
Clean and disinfect the end of the teat and teat orifice thoroughly before applying the
product. Remove the cover of the tip and infuse the product gently into the teat. The
intramammary syringe has a double tip. It is recommended to remove only the outer
cover, revealing a tip about 5 mm long. Using the shorter tip reduces the mechanical
irritation of the teat canal when the veterinary medicinal product is applied (partial

Revised October 2025
AN: 03744/2024 & 03743/2024
insertion). If the inner cover is removed as well, a tip of about 20 mm is revealed.
This can be used only exceptionally to facilitate infusion, for instance to a teat with
pronounced oedema (full insertion). The partial insertion technique is preferred,
whenever achievable. After infusion, the quarter is massaged so that the drug is
evenly distributed.
3.10 Symptoms of overdose (and where applicable, emergency procedures and
antidotes)
Not applicable.
3.11 Special restrictions for use and special conditions for use, including
restrictions on the use of antimicrobial and antiparasitic veterinary
medicinal products in order to limit the risk of development of resistance
Not applicable.
3.12 Withdrawal periods
Milk: 6 days.
Meat and offal: 3 days.
4.