POM-V Prescription Required Companion Animal

Depocillin 300 mg/ml Suspension for Injection

Active ingredient: Procaine Benzylpenicillin

Form

Injection

Species

Cats Cattle Dogs Horses Pigs Sheep

Manufacturer

Intervet International B.V.

VMD MA No.

06376/4081

What it's used for

Amended pages: October 2025 AN: 01920/2024Page 2 of 6

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Procaine Benzylpenicillin

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Depocillin 300 mg/ml Suspension for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Amended pages: October 2025
AN: 01920/2024Page 2 of 6

Dogs and cats 30 mg/kg (1 ml per 10 kg bodyweight). Subcutaneous use.
Suggested doses are:
Cattle 500 kg 20 ml
Horses 500 kg 20 ml
Sheep 50 kg 2.5 ml
Pigs 50 kg 2.5 ml
Dogs 10 kg 1 ml
Cats 5 kg 0.5 ml
Clean the area of the injection site and swab with spirit. Shake well before use.
The treatment duration is 3 to 7 days and should be repeated at 24 hour intervals.
Do not use the same injection site more than once during a course of treatment.
Do not inject more than 20 ml per injection site in cattle.
Do not inject more than 5 ml per injection site in pigs and sheep.

Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use in rabbits, guinea pigs, hamsters or gerbils. Caution is advised in its use in
any other small herbivores.
Not effective against beta-lactamase producing organisms.

Cattle, horses, sheep, dogs, cats:
Very rare
(<1 animal / 10,000 animals
treated, including isolated reports):
Hypersensitivity reaction, Anaphylaxis
;
Injection site reaction (e.g.,swelling, pain)
Pigs:
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Hypersensitivity reaction, Anaphylaxis
;
Vomiting
;
Injection site reaction (e.g. swelling, pain)
May be life-threatening. Potentially fatal reactions associated with the administration of
procaine penicillin in horses have been observed. If such reactions occur appropriate
treatment is recommended.
In sucking and fattening pigs.
Systemic toxic effects have been observed in young piglets, which are transient but can
be potentially lethal, especially at higher doses.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Occasionally in sucking and fattening pigs, administration of products containing
procaine penicillin may cause a transient pyrexia, vomiting, shivering, listlessness and
incoordination. Additionally in pregnant sows and gilts a vulval discharge which could
be associated with abortion has been reported.
After absorption, benzylpenicillin poorly penetrates biological membranes (e.g., blood-
brain barrier) since it is ionised and poorly lipid soluble. Use of the product for treatment
of meningitis or CNS infections due to e.g., Streptococcus suis
monocytogenes may not be efficacious. Furthermore, benzylpenicillin penetrates
mammalian cells poorly and hence this product may have little effect in treating
intracellular pathogens e.g., Listeria monocytogenes.
Elevated MIC values or bi-modal distribution profiles suggesting acquired resistance
have been reported for the following bacteria:
-, Staphylococcus spp. causing MMA/PPDS, Streptococcus
spp. and S. suis in pigs;
- causing metritis and Mannheimia haemolytica (only
in some member states), as well as Bacteroides spp., Staphylococcus
chromogenes, Actinobacillus lignieresii and in cattle;
-, coagulase negative Staphylococci and Enterococcus spp. in dogs;
- and Staphylococcus felis in cats.
Use of the veterinary medicinal product may result in a lack of clinical efficacy when
treating infections caused by these bacteria.

Special precautions for safe use in the target species:
Not recommended for intravenous or intrathecal administration.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Penicillin and cephalosporins may cause hypersensitivity (allergy) following injection,
inhalation, ingestion or skin contact. Hypersensitivity to penicillin may lead to cross

Amended pages: October 2025
AN: 01920/2024Page 3 of 6
reactions to cephalosporins and vice versa. Allergic reactions to these substances are
occasionally serious.
1. Do not handle this product if you know you are sensitised or if you have been
advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all recommended
precautions.
3. If you develop symptoms following exposure, such as a skin rash, you should seek
medical advice and show the doctor this warning. Swelling of the face, lips or eyes
or difficulty with breathing are more serious symptoms and require urgent medical
attention.
Wash hands after use.
Special precautions for the protection of the environment:
Not applicable.

Antagonism between the product and bacteriostatic preparations may occur. Resistant
bacteria, particularly gram-negative, that show a cross-resistance with other beta-
lactam antibiotics might occur.

Store in a refrigerator (2 °C – 8 °C). Do not freeze.
Keep the vial in the outer carton in order to protect from light.

Meat and offal:
Cattle, pigs, sheep: 5 days for the treatment duration 3-5 days
7 days for the treatment duration 6-7 days)
Horses: Not to be used in horses intended for human consumption. Treated horses may
never be slaughtered for human consumption. The horse must have been declared as
not intended for human consumption under national horse passport legislation.

Amended pages: October 2025
AN: 01920/2024Page 5 of 6Milk:
Cattle: 264 hours (11 days)
Sheep, horses: Not authorised for use in animals producing milk for human
consumption.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.