POM-V Prescription Required

Norocillin 30% w/v Suspension for Injection

Active ingredient: Procaine Benzylpenicillin

Form

Injection

Species

Cattle Pigs Sheep

Manufacturer

Norbrook Laboratories Limited

VMD MA No.

02000/4099

What it's used for

For the treatment of systemic infections caused by or associated with organisms sensitive to penicillin. In vitro tests have shown the following organisms...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Procaine Benzylpenicillin

1

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They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

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Prescription required

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Clinical information

Norocillin 30% w/v Suspension for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of systemic infections caused by or associated with organisms
sensitive to penicillin.
In vitro tests have shown the following organisms to be sensitive:
pyogenes, Erysipelothrix rhusiopathiae, Listeria, Mannheima haemolytica,
Pasteurella multocida, Staphylococcus spp (non-penicillinase producing) and
Streptococcus spp.
Norocillin is recommended, therefore, in the treatment of diseases caused by
susceptible organisms including:
erysipelas; navel/joint-ill; respiratory tract infections including pneumonia and
atrophic rhinitis; listeriosis; septicaemia; urogenital tract infections and the control of
secondary bacterial invaders in diseases of primary viral origin.

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Administer by deep intramuscular injection only.
The recommended dose rate is: 10 mg/kg bodyweight (1ml/30 kg) daily for 3 to 7
days.
To ensure the correct dosage, bodyweight should be determined as accurately as
possible to avoid underdosing.
The appropriate treatment duration should be chosen based on the clinical needs
and individual recovery of the treated animal. Consideration should be given to the
accessibility of the target tissue and characteristics of the target pathogen.

Do not inject intravenously or intrathecally.
Do not use in known cases of hypersensitivity to penicillin.
Not to be used on very small herbivores such as guinea pigs, gerbils and hamsters.

Very rarely, in sucking and fattening pigs, administration may cause a transient
pyrexia, vomiting, shivering, listlessness and in-coordination.
In very rare cases hypersensitivity reactions may occur. Such reactions may evolve
to a more severe condition (anaphylaxis), which may be life-threatening. Potentially
fatal reactions associated with the administration of procaine penicillin in horses
have been observed.
The frequency of adverse reactions is defined using the following convention:
very common (more than 1 in 10 animals displaying adverse reactions during the
course of one treatment)
common (more than 1 but less than 10 animals in 100 animals)
uncommon (more than 1 but less than 10 animals in 1,000 animals)
rare (more than 1 but less than 10 animals in 10,000 animals)
very rare (less than 1 animal in 10,000 animals, including isolated reports).
Systemic toxic effects have been observed in young piglets, which are transient but
can be potentially lethal, especially at higher doses.

After absorption, benzylpenicillin poorly penetrates biological membranes (e.g.,
blood-brain barrier) since it is ionised and poorly lipid soluble. Use of the product for
treatment of meningitis or CNS infections due to e.g.,
monocytogenes
mammalian cells poorly and hence this product may have little effect in treating
intracellular pathogens e.g., Listeria monocytogenes.
Elevated MIC values or bi-modal distribution profiles suggesting acquired resistance
have been reported for the following bacteria:
Glaesserella parasuis, spp. causing MMA/PPDS,
spp. and S. suis in pigs;
Fusobacterium necrophorum causing metritis and as well
as spp., and
Trueperella pyogenes in cattle.
Use of the veterinary medicinal product may result in a lack of clinical efficacy when
treating infections caused by these bacteria.

(i) Special precautions for use in animals
Shake the container before use.
Care should be taken not to overdose.
Use of the product should be based on susceptibility testing of the bacteria isolated
from the animal. If this is not possible, therapy should be based on local
epidemiological information.
(ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Care should be taken to avoid accidental self-injection.
Penicillins and cephalosporins may cause hypersensitivity (allergy) following
injection, inhalation, ingestion or skin contact. Hypersensitivity to penicillins may
lead to cross-reactions to cephalosporins and vice versa. Allergic reactions to these
substances may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you have been
advised not to work with such preparations.
2. Handle this product with great care to avoid exposure, taking all
recommended precautions.
3. If you develop symptoms following exposure such as a skin rash, you should
seek medical advice and show the doctor this warning. Swelling of the face,

Revised: June 2024
AN: 03938/2023Page 3 of 5
lips or eyes or difficulty with breathing are more serious symptoms and require
urgent medical attention.
Wash hands after use.

None known.

Following withdrawal of the first dose, use the product within 28 days.
Discard unused material.
Store in a refrigerator (2ºC – 8ºC).
Protect from light.

Cattle: Milk – 84 Hours.
Cattle, sheep and pigs
Meat and offal: 7 days for treatment duration 3-5 days
9 days for treatment duration 6-7 days
Do not use in sheep producing milk for human consumption.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.