POM-V Prescription Required

Pen & Strep Suspension for Injection

Active ingredients: Dihydrostreptomycin Sulphate, Procaine Benzylpenicillin

Form

Injection

Species

Cattle Horses Pigs Sheep

Manufacturer

Norbrook Laboratories Limited

VMD MA No.

02000/4100

What it's used for

For the treatment of systemic infections in cattle, horses, sheep and pigs caused by or associated with organisms sensitive to penicillin and/or streptomyc...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Dihydrostreptomycin Sulphate...

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Pen & Strep Suspension for Injection — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For the treatment of systemic infections in cattle, horses, sheep and pigs
caused by or associated with organisms sensitive to penicillin and/or
streptomycin including:
Arcanobacterium pyogenes
Erysipelothrix rhusiopathiae
Klebsiella pneumoniae
Listeria
Mannheimia haemolytica
Pasteurella multocida
Staphylococcus spp (non-penicillinase producing)
Streptococcus spp
Salmonella spp

Amended pages: October 2025
AN: 00356/2024
and for the control of secondary bacterial infection with sensitive organisms in
diseases primarily associated with viral infection.

Shake the vial before use.
Administer by deep intramuscular injection.
Recommended dosage rate is 8 mg/kg bodyweight procaine penicillin with 10
mg/kg bodyweight dihydrostreptomycin sulphate equivalent to 1 ml per 25 kg
bodyweight. Treatment should be given once daily for up to 3 consecutive
days. The maximum dose volume administered at one site should not exceed
15 ml for horses, 6 ml for cattle, 3 ml for sheep and 1.5 ml for pigs.

Contraindicated in known cases of hypersensitivity to penicillins.

In rare cases, hypersensitivity reactions can occur and very rarely, these can
be fatal. Very rarely, in sucking and fattening pigs, administration may cause
a transient pyrexia, vomiting, shivering, listlessness and incoordination. A
palpable but transient local reaction may occur at the site of intramuscular
administration in horses.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions
during the course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports).

Use with care in animals known to have kidney disease or defective renal
function.
Do not exceed the recommended dosage or duration of treatment.

i. Special precautions for use in animals:
Care should be taken not to exceed the recommended dosage.
Aminoglycosides have a narrower margin of safety than beta lactam
antibiotics.
ii. Special precautions to be taken by the person administering the
product to the animals:
Care should be taken to avoid accidental self-injection. In the case of
accidental self-injection, seek medical advice immediately.
Penicillins and cephalosporins may cause hypersensitivity (allergy)
following injection, inhalation, ingestion or skin contact.
Hypersensitivity to penicillins may lead to cross-reactions to
cephalosporins and vice versa. Allergic reaction to these substances
may occasionally be serious.
1. Do not handle this product if you know you are sensitised, or if you
have been advised not to work with such preparations.
2. Handle this product with great care to avoid exposure taking all
recommended precautions.
3. If you develop symptoms following exposure, such as a skin rash,
you should seek medical advice and show the doctor this warning.
Swelling of the face, lips or eyes or difficulty in breathing are more
serious symptoms and require urgent medical attention.
Wash hands after use.

Amended pages: October 2025
AN: 00356/2024

interaction
Do not administer with other antibiotics such as tetracyclines or with other
aminoglycosides.

Animals must not be slaughtered for human consumption during treatment.
Sheep:
Not to be used in sheep producing milk for human consumption.
Sheep intended for human consumption should not be slaughtered until 31
days after the last treatment.

Amended pages: October 2025
AN: 00356/2024
Cattle:
Milk for human consumption must not be taken during treatment. Milk for
human consumption may only be taken from cows after 60 hours from the last
treatment.
Cattle intended for human consumption should not be slaughtered until 23
days after the last treatment.
Pigs:
Pigs intended for human consumption should not be slaughtered until 18 days
after the last treatment.
Horses:
Not to be used in horses intended for human consumption.
Treated horses may never be slaughtered for human consumption.
The horse must have been declared as not intended for human consumption
under national horse passport legislation
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.