Tyawalt 450 mg/g Granules for Use in Drinking Water for Pigs

Guidance for preparing product solutions:
When medicating large volumes of water, prepare a concentrated solution first
and then dilute to the required final concentration. Alternatively, the
concentrated solution can be used in a proportional water medicator. The
solubility of the product has been confirmed at the maximal concentration of
100 g of product/L in soft and hard water and at 4°C and 20°C.
Medicated drinking water should be refreshed or replaced every 24 hours.

Revised November 2024
Make sure the animals do not have access to non-medicated water during the
period when the medicated water is given.
After the end of the medication period the water supply system should be
cleaned appropriately to avoid intake of sub-therapeutic amounts of the active
substance.
To ensure a correct dosage, body weight should be determined as accurately
as possible.
The intake of medicated water depends on the clinical condition of the
animals. In order to obtain the correct dosage, the concentration of tiamulin
may need to be adjusted accordingly
In order to avoid interactions between the ionophores and tiamulin, the
veterinarian and farmer should check that the feed label does not state that it
contains salinomycin, monensin and narasin.
The feed should be tested for the ionophores prior to use if there is any
suspicion that contamination of the feed might occur.
If an interaction does occur, stop tiamulin medication immediately and replace
with fresh drinking water. Remove contaminated feed as soon as possible and
replace with feed not containing the tiamulin-incompatible ionophores.
Based on the recommended dose and the number and weight of animals to
be treated, the exact daily concentration of the veterinary medicinal product
should be calculated according to the following formula:
x mg veterinary
medicinal product/ kg
body weight per day
X
average body
weight (kg) of
animals to be
treated
average daily water intake (l/animal)
= x mg veterinary
medicinal product per
litre of drinking water
Brachyspira
hyodysenteriae: 8.8 mg tiamulin hydrogen fumarate (equivalent to 19.6
mg of product)/kg body weight administered daily in the drinking water of
pigs for 3 to 5 consecutive days depending on the severity of the
infection and/or the duration of the disease.

Brachyspira pilosicoli: 8.8 mg tiamulin hydrogen fumarate (equivalent to
19.6 mg of product)/kg body weight administered daily in the drinking
water of pigs for 3 to 5 consecutive days depending on the severity of
the infection and/or the duration of the disease.

Lawsonia intracellularis: 8.8 mg tiamulin hydrogen fumarate (equivalent

Revised November 2024
to 19.6 mg of product)/kg body weight administered daily in the drinking
water of pigs for 5 consecutive days.

Mycoplasma hyopneumoniae, including infections complicated by
Pasteurella multocida
44.4 mg of product)/kg body weight administered daily for 5 consecutive
days.

pleuropneumoniae: 20 mg tiamulin hydrogen fumarate (equivalent to
44.4 mg of product)/kg body weight administered daily for 5 consecutive
days.