POM-V Prescription Required

Soludox 500 mg/g Powder for Use in Drinking Water for Turkeys

Active ingredient: Doxycycline Hyclate

Form

Powder

Species

Turkeys

Manufacturer

Eurovet Animal Health B.V.

VMD MA No.

16849/4046

What it's used for

Chickens: Where clinical disease is present in the flock, to reduce mortality, morbidity, and clinical signs and to reduce lesions due to Pasteurellosis ca...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Doxycycline Hyclate

1

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2

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Prescription required

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Clinical information

Soludox 500 mg/g Powder for Use in Drinking Water for Turkeys — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Chickens: Where clinical disease is present in the flock, to reduce mortality,
morbidity, and clinical signs and to reduce lesions due to Pasteurellosis caused by
Pasteurella multocida
caused by

Dosage: 25 mg doxycycline corresponding to 29 mg doxycycline hyclate per kg of
body weight daily (equivalent to 58 mg veterinary medicinal product per kg of body
weight), administered in the drinking water for 5 consecutive days.
AN: 04419/2024 & 04421/2024
The veterinary medicinal product should be administered continuously in the drinking
water during the whole period of treatment.
Based on the recommended dose and the number and weight of animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated according to the following formula:
58 mg veterinary
medicinal product / kg
body weight per day
x
average body weight
(kg) of birds to be
treated
average daily water intake (l/animal)
= .... mg veterinary
medicinal product per litre
of drinking water
To ensure a correct dosage, body weight should be determined as accurately as
possible. The intake of medicated drinking water depends on the clinical condition of
the birds. In order to obtain the correct dosage the concentration of doxycycline has
to be adjusted accordingly. The use of suitably calibrated weighing equipment is
recommended if part packs are used. The daily amount is to be added to the drinking
water such that all medication will be consumed within 24 hours. Medicated drinking
water should be refreshed or replaced every 24 hours. It is recommended to prepare
a concentrated pre-solution - approximately 100 grams veterinary medicinal product
per litre drinking water - and to dilute this further to therapeutic concentrations if
required. Alternatively, the concentrated solution can be used in a proportional water
medicator. Solubility of the veterinary medicinal product is pH-dependent and it may
precipitate out if it is mixed in hard alkaline drinking water. Use at minimum
concentrations of 200 mg powder per litre drinking water in areas with hard alkaline
drinking water (hardness above 10.2°d and pH more than 8.1). During the treatment
period birds should not have access to water sources other than the medicated
water.

Do not use in case of hypersensitivity to the active substance or to any of the
excipients.
Do not use in animals with hepatic and/or renal dysfunction.
Do not use when tetracycline resistance has been detected in the flock due to the
potential for cross-resistance.

Turkeys (for meat production, for reproduction):
Rare
(1 to 10 animals / 10,000
animals treated):
Allergic reaction*
Photosensitivity*
*If suspected adverse events occur, treatment should be discontinued.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the immediate packaging
or package leaflet for respective contact details.

The uptake of medication by animals can be altered as a consequence of illness. In
case of insufficient uptake of drinking water, turkeys should be treated parenterally.
AN: 04419/2024 & 04421/2024

Special precautions for safe use in the target species:
Official, national and regional antimicrobial policies should be taken into account
when the veterinary medicinal product is used.
Use of the veterinary medicinal product deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to doxycycline and may
decrease the effectiveness of treatment with other tetracyclines due to the potential
for cross-resistance.
Due to likely variability (time, geographical) in susceptibility of bacteria for
doxycycline bacteriological sampling and susceptibility testing are recommended. In
particular susceptibility of O.rhinotracheale may differ from country to country and
even farm to farm.
Use of the veterinary medicinal product should be based on culture and sensitivity of
micro-organisms from diseased cases on farm. If this is not possible, therapy should
be based on local (regional, farm level) epidemiological information about
susceptibility of the target bacteria. As eradication of the target pathogens may not
be achieved, medication should therefore be combined with good management
practices, e.g. good hygiene, proper ventilation, no overstocking.
Avoid administration in oxidised drinking equipment.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This veterinary medicinal product may cause contact dermatitis and/or
hypersensitivity reactions if contact is made with the skin or eyes (powder and
solution) or if the veterinary medicinal product is inhaled.
If you know you are allergic to the tetracycline class of antibiotics, special care
should be taken when handling this veterinary medicinal product or the medicated
solution.
During preparation and administration of the medicated drinking water, skin contact
with the veterinary medicinal product and inhalation of dust particles should be
avoided. Wear impermeable gloves (e.g. rubber or latex) and an appropriate dust
mask (e.g. disposable half-mask respirator conforming to European Standard EN149)
when applying the veterinary medicinal product.
In the event of eye or skin contact, rinse the affected area with large amounts of
clean water and if irritation occurs, seek medical attention. Wash hands and
contaminated skin immediately after handling the veterinary medicinal product.
If you develop symptoms following exposure such as skin rash, you should seek
medical advice and show this warning to the physician. Swelling of the face, lips or
eyes, or difficulty with breathing are more serious symptoms and require urgent
medical attention.
Do not smoke, eat or drink while handling the veterinary medicinal product.
Take measures to avoid producing dust when incorporating the veterinary medicinal
product into water. Avoid direct contact with skin and eyes when handling the
veterinary medicinal product to prevent sensitisation and contact dermatitis.
AN: 04419/2024 & 04421/2024
Special precautions for the protection of the environment:
Not applicable.

Do not administer in conjunction with bactericidal antibiotics such as beta-lactams as
tetracyclines are bacteriostatic antimicrobials. Absorption of doxycycline can be
decreased in the presence of high quantities of calcium, iron, magnesium or
aluminium in the diet. Do not administer together with antacids, kaolin or iron
preparations.
It is advised that the interval between the administration of other products containing
polyvalent cations should be 1-2 hours because they limit the absorption of
tetracyclines.
Doxycycline increases the action of anticoagulants.
The solubility of the veterinary medicinal product is pH-dependent and it will
precipitate out if mixed in alkaline solutions.
Do not store the drinking water in metallic containers.

This veterinary medicinal product does not require any special storage conditions.
Keep the bag tightly closed after first opening in order to protect from moisture.

Turkeys:
Meat and offal: 12 days.
Not for use in birds producing eggs for human consumption.
AN: 04419/2024 & 04421/2024
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.