POM-V Prescription Required

Doxatib 500 mg/g Powder for Use in Drinking Water for Pigs and Chickens

Active ingredient: Doxycycline Hyclate

Form

Powder

Species

Chickens Pigs

Manufacturer

KRKA, d.d., Novo mesto

VMD MA No.

01656/5053

What it's used for

Pigs: For the treatment of the clinical signs associated with porcine respiratory disease caused by Actinobacillus pleuropneumoniae, Pasteurella multocida,...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Doxycycline Hyclate

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Doxatib 500 mg/g Powder for Use in Drinking Water for Pigs and Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Pigs: For the treatment of the clinical signs associated with porcine respiratory
disease caused by Actinobacillus pleuropneumoniae, Pasteurella multocida, and
Mycoplasma hyopneumoniae susceptible to doxycycline.
Chickens: Where clinical disease is present in the flock, to reduce mortality,
morbidity, and clinical signs and to reduce lesions due to Pasteurellosis caused by
Pasteurella multocida
caused by

In drinking water use .
Pigs: the recommended dose is:
12.5 mg doxycycline hyclate (25 mg veterinary medicinal product) per kg body weight
per day for 4 consecutive days.
If no improvement in clinical signs is seen within this time, the diagnosis should be
reviewed and treatment changed. In case of severe infections the medication period

Revised: July 2023
AN: 02711/2022Page 4 of 7
may be prolonged for a maximum of 8 consecutive days as determined by the
attending veterinary surgeon.
Chickens: the recommended dose is:
10 mg doxycycline hyclate (20 mg veterinary medicinal product) per kg body weight
per day for 3-4 consecutive days in case of infections caused by P. multocida
20 mg doxycycline hyclate (40 mg veterinary medicinal product) per kg body weight
per day for 3-4 consecutive days in case of infections caused by O. rhinotracheale.
Based on the recommended dose to be used and the number and weight of the
animals to be treated, the exact daily concentration of the veterinary medicinal
product should be calculated according to the following formula:
mg veterinary medicinal
product / kg body weight /
day
x
average body weight (kg)
of animals to be treated
average daily water intake (l/animal)
=
mg veterinary
medicinal
product per
litre of
drinking
water
To ensure a correct dosage, body weight should be determined as accurately as
possible to avoid underdosing.
The intake of medicated water depends on the clinical condition of the animals. In
order to obtain the correct dosage, the concentration of doxycycline may need to be
adjusted accordingly.
The use of suitably calibrated weighing equipment is recommended if part packs are
used. The daily amount is to be added to the drinking water such that all medication
will be consumed in 24 hours. Medicated water should be replaced every 24 hours.
It is recommended to prepare a concentrated pre-solution - approximately 100 grams
product per litre drinking water - and to dilute this further to therapeutic
concentrations if required. Alternatively, the concentrated solution can be used in a
proportional water medicator.
Solubility of the veterinary medicinal product is pH dependent and it may precipitate if
it is mixed in hard alkaline drinking water. Use at minimum concentrations of 200 mg
powder per litre drinking water in areas with hard alkaline drinking water (hardness
above 10.2 °d and pH more than 8.1).
Do not store the medicated water in metallic containers.
It should be ensured that all animals intended for treatment should have free access
to the drinking facilities.
During the treatment period animals should not have access to other water sources
than the medicated water.
Water uptake should be monitored at frequent intervals during medication.
After the end of the medication period, the water supply system should be cleaned
appropriately to avoid intake of sub-therapeutic amounts of the active substance.

Revised: July 2023
AN: 02711/2022Page 5 of 7

Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use in animals with an impaired liver function.
Do not use in animals with renal disorders.
Do not use when tetracycline resistance has been detected in the herd/flock due to
the potential for cross resistance.

Revised: July 2023
AN: 02711/2022Page 2 of 7

Pig and chicken:
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Allergic condition*
Photosensitivity*
*If suspected adverse reactions occur, treatment should be discontinued.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See also the section “Contact details” of the package
leaflet for contact details.

The uptake of medication by animals can be altered as a consequence of illness. In
case of insufficient uptake of drinking water, animals should be treated parenterally.

i) Special precautions for use in animals
Official, national and regional antimicrobial policies should be taken into account
when the veterinary medicinal product is used.
Use of the veterinary medicinal product deviating from the instructions given in the
SPC may increase the prevalence of bacteria resistant to doxycycline and may
decrease the effectiveness of treatment with other tetracyclines due to the potential
for cross-resistance.
Resistance to tetracyclines has also been reported in pig respiratory pathogens (A.
pleuropneumoniae) in some European countries.
Due to likely variability (time, geographical) in the occurrence of resistance of
bacteria against doxycycline bacteriological sampling and susceptibility testing are
recommended. In particular susceptibility of A. pleuropneumoniae and O.
rhinotracheale may differ from country to country and even farm to farm. Use of the
veterinary medicinal product should be based on susceptibility testing of the bacteria
isolated from the animal. If this is not possible, therapy should be based on local
(regional, farm level) epidemiological information about susceptibility of the target
bacteria.
As eradication of the target pathogens may not be achieved, medication should
therefore be combined with good management practices, e.g. good hygiene, proper
ventilation, no overstocking.
ii)Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This veterinary medicinal product may cause contact dermatitis and/or
hypersensitivity reactions if contact is made with the skin or eyes (powder and
solution), or if the powder is inhaled. People with known hypersensitivity to
tetracyclines should avoid contact with the veterinary medicinal product.
Take measures to avoid producing dust when incorporating the veterinary medicinal
product into water. Avoid direct contact with skin and eyes when handling the
veterinary medicinal product to prevent sensitisation and contact dermatitis.
Inhalation of dust particles should be avoided. Wear impermeable gloves (e.g. rubber
or latex) and an appropriate dust mask (e.g. disposable half-mask respirator
conforming to European Standard EN149 or a non-disposable respirator to European
Standard EN140 with a filter to EN143) when mixing and applying the veterinary
medicinal product.
In the event of eye or skin contact, rinse the affected area with large amounts of
clean water and if irritation occurs, seek medical attention.
If you develop symptoms following exposure such as skin rash, you should seek
medical advice and show this warning to the physician. Swelling of the face, lips or
eyes, or difficulty with breathing are more serious symptoms and require urgent
medical attention.
Wash hands after handling the veterinary medicinal product.
Do not smoke, eat or drink while handling the veterinary medicinal product.

Revised: July 2023
AN: 02711/2022Page 3 of 7
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
Not applicable.

Do not combine with antibiotics that are bactericidal e.g. penicillins or
cephalosporins.
Absorption of doxycycline can be decreased in the presence of high quantities of
calcium, iron, magnesium or aluminium in the diet. Do not administer concurrently
with antacids, kaolin and iron preparations.
It is advised that the interval between the administration of the product and
administration of other products containing polyvalent cations should be 1-2 hours
because the latter limit the absorption of tetracyclines.
Doxycycline increases the action of anticoagulants.

Store below 30 °C.
Store in the original package.
Keep the bag tightly closed after first opening in order to protect from moisture.
Once opened, the veterinary medicinal product should be stored at temperatures
below 25 °C.

Revised: July 2023
AN: 02711/2022Page 7 of 7

Pigs:
- Meat and offal: 4 days
Chickens:
- Meat and offal: 3 days (following a dose rate of 10 mg/kg body weight for 4 days).
- Meat and offal: 9 days (following a dose rate of 20 mg/kg body weight for 4 days).
Do not use within 4 weeks before the start of the laying period.
Not for use in birds producing eggs for human consumption.
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.