POM-V Prescription Required

DFV Doxivet 500 mg/g, Powder for Use in Drinking Water for Pigs and Chickens

Active ingredient: Doxycycline Hyclate

Form

Powder

Species

Chickens Pigs

Manufacturer

Divasa - Farmavic S.A

VMD MA No.

33229/4002

What it's used for

Chickens: Where clinical disease is present in the flock, to reduce mortality, morbidity, and clinical signs and to reduce lesions due to Pasteurellosis ca...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Doxycycline Hyclate

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

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Prescription required

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Clinical information

DFV Doxivet 500 mg/g, Powder for Use in Drinking Water for Pigs and Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Chickens: Where clinical disease is present in the flock, to reduce mortality,
morbidity, and clinical signs and to reduce lesions due to Pasteurellosis caused
by Pasteurella multocida or to reduce morbidity and lesions in respiratory
infections caused by Ornithobacterium rhinotracheale (ORT)

The recommended dose in pigs is:
12.5 mg doxycycline hyclate (25 mg product) per kg body weight per day for 4
consecutive days. If no improvement in clinical signs is seen within this time, the
diagnosis should be reviewed and treatment changed. In case of severe
infections the medication period may be prolonged for a maximum of 8
consecutive days as determined by the attending veterinary surgeon.
The recommended dose in chickens is:
10 mg doxycycline hyclate (20 mg product) per kg body weight per day for 3-4
consecutive days in case of infections caused by
doxycycline hyclate (40 mg product) per kg body weight per day for 3-4
consecutive days in case of infections caused by O. rhinotracheale.
AN: 00784/2025 & 00787/2025
Based on the recommended dose to be used, and the number and weight of the
animals to be treated, the exact daily concentration of the veterinary medicinal
product can be calculated according to the following formula:
....mg veterinary
medicinal product/
kg body Weight per
day
x
average body weight
(kg) of
animals to be treated
average daily water intake (l/animal)= mg veterinary
medicinal
product per litre
of drinking
water
To ensure a correct dosage body weight should be determined as accurately as
possible.
The intake of medicatedwater depends on the clinical condition of the animals. In
order to obtain the correct dosage the concentration of doxycycline has to be
adjusted accordingly. The use of suitably calibrated weighing equipment is
recommended if part packs are used. The daily amount is to be added to the
drinking water such that all medication will be consumed in 24 hours. Medicated
drinking water should be refreshed or replaced every 24 hours. It is recommended
to prepare a concentrated pre-solution - approximately 100 grams product per litre
drinking water - and to dilute this further to therapeutic concentrations if required.
Alternatively, the concentrated solution can be used in a proportional water
medicator. Solubility of the product is pH dependent and it may precipitate if it is
mixed in hard alkaline drinking water. Use at minimum concentrations of 200 mg
powder per litre drinking water in areas with hard alkaline drinking water (hardness
above 10.2 °d and pH more than 8.1). During the treatment period animals should
not have access to other water sources than the medicated water.

Do not use in case of hypersensitivity to the active substance or to any of the
excipients.
Do not use in animals with an impaired liver function.

Pigs and chickens (broiler, pullet, chicken for reproduction).
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Photosensitivity
Allergic reaction
AN: 00784/2025 & 00787/2025
It allows continuous safety monitoring of a veterinary medicinal product. Reports
should be sent, preferably via a veterinarian, to either the marketing authorisation
holder or its local representative or the national competent authority via the national
reporting system. See the package leaflet or the immediate packaging for
respective contact details.

None.
AN: 00784/2025 & 00787/2025

Special precautions for safe use in the target species:
Due to likely variability (time, geographical) in susceptibility of bacteria for
doxycycline, especially susceptibility of
rhinotracheale may differ from country to country and even farm to farm,
bacteriological sampling and susceptibility testing are recommended.
Use of the veterinary medicinal product should be based on culture and sensitivity
of micro-organisms from diseased cases on farm. If this is not possible, therapy
should be based on local (regional, farm level) epidemiological information about
susceptibility of the target bacteria.
As eradication of the target pathogens may not be achieved, medication should
therefore be combined with good management practices, e.g. good hygiene,
proper ventilation, no overstocking.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
If you know you are allergic to the tetracycline class of antibiotics, special care
should be taken when handling this veterinary medicinal product or the medicated
solution.
During preparation and administration of the medicated drinking water, skin
contact with the product and inhalation of dust particles should be avoided.
Personal protective equipment consisting of impermeable gloves (e.g. rubber or
latex) and an appropriate dust mask (e.g. disposable half-mask respirator
conforming to European Standard EN149) should be worn when handling the
veterinary medicinal product.
In the event of eye or skin contact, rinse the affected area with large amounts of
clean water and if irritation occurs, seek medical attention. Wash hands and
contaminated skin immediately after handling the veterinary medicinal product.
If you develop symptoms following exposure such as skin rash, you should seek
medical advice and show this warning to the physician. Swelling of the face, lips
or eyes, or difficulty with breathing are more serious symptoms and require
urgent medical attention.
Do not smoke, eat or drink while handling the veterinary medicinal product.
Take measures to avoid producing dust when incorporating the product into
water. Avoid direct contact with skin and eyes when handling the veterinary
medicinal product to prevent sensitisation and contact dermatitis.
Special precautions for the protection of the environment:
Not applicable

Do not combine with antibiotics that are bactericidal e.g. penicillins or cephalosporins.
Absorption of doxycycline can be decreased in the presence of high quantities of
calcium, iron, magnesium or aluminium in the diet. Do not administered together with
antacids, kaolin and iron preparations.
It is advised that the interval between the administration of other products
containing polyvalent cations should be 1-2 hours because they limit the
absorption of tetracyclines.
Doxycycline increases the action of anticoagulants.
The solubility of the product is pH dependent and will precipitate if mixed in
alkaline solution.
Do not store the drinking water in metallic containers.

This veterinary medicinal product does not require any special storage conditions.

Pigs:
- Meat and offal: 4 days
Chickens:
- Meat and offal: 3 days, following a dose rate of 10 mg/kg body weight for 4 days.
- Meat and offal: 12 days, following a dose rate of 20 mg/kg body weight for 4 days.
- Eggs: Not authorised for use in laying birds producing eggs for human
consumption. Do not use within 4 weeks before the start of the laying period
AN: 00784/2025 & 00787/2025

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.