POM-V Prescription Required

Doxx-Sol 500 mg/g Powder for Use in Drinking Water/Milk Replacer for Pre-ruminant Calves, Pigs and Chickens

Active ingredient: Doxycycline Hyclate

Form

Powder

Species

Cattle Chickens Pigs

Manufacturer

Huvepharma NV

VMD MA No.

30282/4022

What it's used for

Cattle (pre-ruminant): - Bronchopneumonia and pleuropneumonia caused by Pasteurella spp., Streptococcus spp., Trueperella pyogenes, and Mycoplasma spp. Pig...

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Doxycycline Hyclate

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Your prescription rights → VMD register of retailers →

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Doxx-Sol 500 mg/g Powder for Use in Drinking Water/Milk Replacer for Pre-ruminant Calves, Pigs and Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Cattle (pre-ruminant):
- Bronchopneumonia and pleuropneumonia caused by Pasteurella spp., Streptococcus
spp., Trueperella pyogenes, and Mycoplasma spp.
Pigs:
- Atrophic rhinitis caused by Pasteurella multocida Bordetella bronchiseptica
- Bronchopneumonia caused by Pasteurella multocida, Streptococcus suis and
Mycoplasma hyorhinis;
- Pleuropneumonia caused by Actinobacillus pleuropneumoniae.
AN: 03051/2024 & 03053/2024
Chickens (for reproduction, broilers and pullets):
- Infections of the respiratory tract caused by ., Escherichia coli,
Haemophilus paragallinarum and Bordetella avium;
- Enteritis caused by and Clostridium colinum.

Cattle (Pre-ruminant):
for use in milk replacer
10 mg doxycycline hyclate (corresponding to 20 mg of the veterinary medicinal
product) /kg body weight / day, divided over 2 administrations, for 3-5
consecutive days.
Pigs:
for use in drinking water
10 mg doxycycline hyclate (corresponding to 20 mg of the veterinary medicinal
product) /kg body weight / day, for 3-5 consecutive days.
Chickens (for reproduction, broilers and pullets):
for use in drinking water
25 mg doxycycline hyclate (corresponding to 50 mg of the veterinary medicinal
product) /kg body weight / day, for 3-5 consecutive days.
To ensure a correct dosage body weight should be determined as accurately as
possible.
In drinking water:
Clear solution when dissolved in water.
Based on the recommended dose and the number and weight of the animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated according to the following formula:
AN: 03051/2024 & 03053/2024
mg veterinary
medicinal product / kg
body weight / day
x average body
weight (kg) of
animals to be
treated
average daily water intake(l/animal
= .... mg veterinary
medicinal product per
litre of drinking water
The intake of medicated water depends on the clinical condition of the animals. In order
to obtain the correct dosage, the concentration of doxycycline may need to be adjusted
accordingly.
The use of suitably calibrated measuring equipment is recommended. The daily amount
is to be added to the drinking water such that all medication will be consumed in 24
hours. Medicated drinking water should be freshly prepared every 24 hours. It is
recommended to prepare a concentrated pre-solution - not exceeding 100 grams
product per litre drinking water - and to dilute this further to therapeutic concentrations if
required. Alternatively, the concentrated solution can be used in a proportional water
medicator. The water should be stirred until full dissolution of the product is obtained.
Sufficient access to the system of water supply should be available for the animals to be
treated to ensure adequate water consumption. No other source of drinking water
should be available during the medication period. At the end of treatment period the
water supply should be cleaned adequately to avoid the uptake of remaining quantities
in sub-therapeutic doses.
The solubility of doxycycline decreases at higher pH. Therefore, the product should not
be used in hard alkaline water since precipitation might occur depending on the product
concentration. Delayed precipitation might also occur.
In milk replacer:
The veterinary medicinal product must first be dissolved in water before adding the milk
powder. The medicated milk replacer should be used immediately and should be freshly
prepared after 4hours at the latest.

Do not use in cases of known hypersensitivity to tetracyclines or to any of the
excipients.
Do not use in animals with serious liver or kidney deficiency.
Do not use when tetracycline resistance has been detected in the herd/flock due to the
potential for cross resistance
Do not use in ruminating cattle.

Cattle (pre-ruminant), pigs, chickens (for reproduction, broilers, and pullets).
Rare
(1 to 10 animals / 10 000 animals treated):
Allergic reaction*
Photosensitivity*
*If suspected adverse reactions occur, treatment should be discontinued.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

None.

Special precautions for safe use in the target species:
A high resistance rate of E. coli, isolated from chickens, against tetracyclines has been
documented. Resistance to tetracyclines has also been reported in pig respiratory
pathogens (A. pleuropneumoniaeS. suis) and calf pathogens (Pasteurella spp.) in
some EU countries.
Use of the product should be based on identification and susceptibility testing of the
target pathogens. If it is not possible, therapy should be based on epidemiological
information and knowledge of susceptibility of the target bacteria at farm level, or at
local/regional level.
Use of the product deviating from the instructions given in the SPC may increase the
prevalence of bacteria resistant to doxycycline and may decrease the effectiveness of
treatment.
Official, national and regional antimicrobial policies should be taken into account when
the product is used.
As eradication of the target pathogens may not be achieved, medication should
therefore be combined with good management practices, e.g. good hygiene, proper
ventilation, no overstocking
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Take measures to avoid producing dust when incorporating the veterinary medicinal
product into water. This veterinary medicinal product may cause contact dermatitis
and/or hypersensitivity reactions if contact is made with the skin or eyes (powder and
solution), or if the powder is inhaled.
AN: 03051/2024 & 03053/2024
People with known hypersensitivity to tetracyclines should avoid contact with the
veterinary medicinal product. Personal protective equipment consisting of impermeable
gloves (e.g. rubber or latex) and an appropriate dust mask (e.g. disposable half-mask
respirator conforming to European Standard EN149) should be worn when handling the
veterinary medicinal product. Do not smoke, eat or drink while handling the product.
In case of accidental eye or skin contact, rinse the affected area with large amounts of
clean water and if irritation occurs, seek medical advice immediately and show the
package leaflet or the label to the physician. Wash hands and contaminated skin
immediately after handling the product.
If you develop symptoms following exposure such as skin rash, seek medical advice
immediately and show the package leaflet or the label to the physician. Swelling of the
face, lips or eyes, or difficulty with breathing are more serious symptoms and require
urgent medical attention.
Special precautions for the protection of the environment:
Not applicable.

Do not use in conjunction with bactericidal antibiotics, such as penicillins and
cephalosporins.
Do not administer concurrently with feed overloaded with polyvalent cations such as
Ca
2+
, Mg
2+
, Zn
2+
and Fe
3+
because the formation of doxycycline complexes with these
cations is possible. Do not administer together with antacids, kaolin and iron
preparations. It is advised that the interval between administration of the veterinary
medicinal product and administration of products containing polyvalent cations should
be 1-2 hours because the latter limit the absorption of doxycycline.
Doxycycline increases the action of anticoagulants.

This veterinary medicinal product does not require any special storage conditions.

Meat and offal:
Cattle (pre-ruminant): 7 days
Pigs: 8 days
Chickens (for reproduction, broilers and pullets: 5 days
Not for use in birds producing or intended to produce eggs for human consumption.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.