POM-V Prescription Required

Soludox 500 mg/g Powder for Use in Drinking Water for Pigs and Chickens

Active ingredient: Doxycycline Hyclate

Form

Powder

Species

Chickens Pigs

Manufacturer

Eurovet Animal Health B.V.

VMD MA No.

16849/4015

What it's used for

Chickens: Where clinical disease is present in the flock, to reduce mortality, morbidity, and clinical signs and to reduce lesions due to Pasteurellosis ca...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Doxycycline Hyclate

1

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They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

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Prescription required

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Clinical information

Soludox 500 mg/g Powder for Use in Drinking Water for Pigs and Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Chickens: Where clinical disease is present in the flock, to reduce mortality,
morbidity, and clinical signs and to reduce lesions due to Pasteurellosis caused by
Pasteurella multocida
caused by

The recommended dose in pigs is:
12.5 mg doxycycline hyclate (25 mg veterinary medicinal product) per kg body
weight per day for 4 consecutive days. If no improvement in clinical signs is seen
within this time, the diagnosis should be reviewed and treatment changed. In case of
severe infections the medication period may be prolonged for a maximum of 8
consecutive days as determined by the attending veterinary surgeon.
AN: 04294/2024 & 04295/2024
The recommended dose in chickens is:
10 mg doxycycline hyclate (20 mg veterinary medicinal product) per kg body weight
per day for 3-4 consecutive days in case of infections caused by P. multocida and
20 mg doxycycline hyclate (40 mg veterinary medicinal product) per kg body weight
per day for 3-4 consecutive days in case of infections caused by O. rhinotracheale.
Based on the recommended dose and the number and weight of animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated according to the following formula:
mg veterinary medicinal
product / kg body weight per
day
x
average body weight
(kg) of animals to be
treated
average daily water intake (l/animal)= .... mg veterinary
medicinal product
per litre of drinking
water
To ensure a correct dosage body weight should be determined as accurately as
possible.
The intake of medicated drinking water depends on the clinical condition of the
animals. In order to obtain the correct dosage the concentration of doxycycline has
to be adjusted accordingly. The use of suitably calibrated weighing equipment is
recommended if part packs are used. The daily amount of veterinary medicinal
product required is to be added to the drinking water such that all medication will be
consumed in 24 hours. Medicated drinking water should be refreshed or replaced
every 24 hours. It is recommended to prepare a concentrated pre-solution -
approximately 100 grams veterinary medicinal product per litre drinking water - and
to dilute this further to therapeutic concentrations if required. Alternatively, the
concentrated solution can be used in a proportional water medicator. Solubility of the
veterinary medicinal product is pH dependent and it may precipitate if it is mixed in
hard alkaline drinking water. Use at minimum concentrations of 200 mg powder per
litre drinking water in areas with hard alkaline drinking water (hardness above 10.2
°d and pH more than 8.1). During the treatment period animals should not have
access to water sources other than the medicated water.

Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Do not use in animals with an impaired liver function.

Pigs and chickens (broilers, pullets, breeders):
Very rare
(<1 animal / 10 000 animals
treated, including isolated
reports):
Allergic reaction*
Photosensitivity*
*If these adverse events occur treatment should be discontinued.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the immediate packaging
for respective contact details.

None.
AN: 04294/2024 & 04295/2024

Special precautions for safe use in the target species:
Due to the likely variability (time, geographical) in susceptibility of bacteria to
doxycycline, especially in susceptibility of A. pleuropneumoniae and O.
rhinotracheale which may differ from country to country and even farm to farm,
bacteriological sampling and susceptibility testing are recommended. Use of the
veterinary medicinal product should be based on the culture and sensitivity of micro-
organisms from diseased cases on the farm. If this is not possible, therapy should be
based on local (regional, farm level) epidemiological information about susceptibility
of the target bacteria.
As eradication of the target pathogens may not be achieved, medication should
therefore be combined with good management practices, e.g. good hygiene, proper
ventilation, no overstocking.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
People with known hypersensitivity to the tetracycline class of antibiotics should
handle this veterinary medicinal product or the medicated solution with caution.
During preparation and administration of the medicated drinking water, skin contact
with the veterinary medicinal product and inhalation of dust particles should be
avoided. Personal protective equipment consisting of impermeable gloves (e.g.
rubber or latex) and an appropriate dust mask (e.g. disposable half-mask respirator
conforming to European Standard EN149) should be worn when applying the
veterinary medicinal product.
In case of accidental eye or skin contact, rinse the affected area with large amounts
of clean water and if irritation occurs, seek medical attention. Wash hands and
contaminated skin immediately after handling the veterinary medicinal product.
If you develop symptoms following exposure such as skin rash, you should seek
medical advice and show the package leaflet or the label to the physician. Swelling
of the face, lips or eyes, or difficulty with breathing are more serious symptoms and
require urgent medical attention.
Do not smoke, eat or drink while handling the veterinary medicinal product.
Take measures to avoid producing dust when incorporating the veterinary medicinal
product into water. Avoid direct contact with skin and eyes when handling the
veterinary medicinal product to prevent sensitisation and contact dermatitis.
Special precautions for the protection of the environment:
Not applicable.
AN: 04294/2024 & 04295/2024

Do not combine with antibiotics that are bactericidal, e.g. penicillins or
cephalosporins.
Absorption of doxycycline can be decreased in the presence of high quantities of
calcium, iron, magnesium or aluminium in the diet. Do not administer together with
antacids, kaolin and iron preparations.
It is advised that the interval between the administration of other products containing
polyvalent cations should be 1-2 hours because they limit the absorption of
tetracyclines.
Doxycycline increases the action of anticoagulants.
The solubility of the veterinary medicinal product is pH dependent and it will
precipitate if mixed in alkaline solution.
Do not store the drinking water in metallic containers.

Keep the sachet tightly closed after first opening in order to protect from moisture.

Pigs:
Meat and offal: 4 days.
Chickens:
Meat and offal: 3 days, following a dose rate of 10 mg/kg body weight for 4 days.
Meat and offal: 9 days, following a dose rate of 20 mg/kg body weight for 4 days.
Not for use in birds producing eggs for human consumption.
Do not use within 4 weeks before the start of the laying period.
4.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.