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POM-V Prescription Required

Pharmasin 250000 IU/g Premix for Medicated Feeding Stuff for Pigs, Broilers and Pullets

Active ingredient: Tylosin

Form

Premix

Species

Chickens Pigs

Manufacturer

Huvepharma N.V.

VMD MA No.

30282/3011

What it's used for

Chickens (broilers and pullets: - Treatment and metaphylaxis of respiratory infections caused by Mycoplasma gallisepticum and Mycoplasma synoviae, when the...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Tylosin

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Pharmasin 250000 IU/g Premix for Medicated Feeding Stuff for Pigs, Broilers and Pullets — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Chickens (broilers and pullets:
- Treatment and metaphylaxis of respiratory infections caused by
Mycoplasma gallisepticum and Mycoplasma synoviae, when the
disease has been diagnosed in the flock.
- Treatment and metaphylaxis of necrotic enteritis caused by
Clostridium perfringens, when the disease has been diagnosed in
the flock.
AN: 00403/2023Page 2 of 7
Administration through the feed: for the preparation of a medicated feed
containing 40 000 000-1 100 000 000 IU tylosin per ton of feed, the required
amount of veterinary medicinal product should be homogenously mixed with a
suitable carrier into a feed premixture so that at least 5 kg of this premixture can
be added to the feed in order to obtain a medicated feed with the required
concentration.
For the preparation of medicated feed:
As 1 kg of veterinary medicinal product contains 250 000 000 IU tylosin it
follows that 4 mg Pharmasin 250 000 IU/g premix corresponds to 1000 IU
tylosin.
AN: 00403/2023Page 4 of 7
The dosages are as follows:
Pigs
For the treatment and metaphylaxis of porcine intestinal adenomatosis (PIA):
4000 – 5000 IU tylosin per kg BW (corresponding to 16 - 20 mg veterinary
medicinal product per kg BW) for 3 weeks.
Chickens (broilers and pullets)
For the treatment and metaphylaxis of respiratory infections:
127 000 IU tylosin per kg BW (corresponding to 508 mg veterinary medicinal
product per kg BW) for the first 5 days of life
For the treatment and metaphylaxis of necrotic enteritis:
10 000 – 20 000 IU tylosin per kg BW (corresponding to 40 – 80 mg veterinary
medicinal product per kg BW) for 7 days.
For the preparation of the medicated feed the body weight of the animals to be
treated and their actual daily feed consumption should be taken into due
account. Consumption may vary depending on factors like age, breed,
husbandry system. To ensure a correct dosage, body weight should be
determined as accurately as possible.
Based on the recommended dose and the number and weight of animals to be
treated, the exact daily concentration of the veterinary medicinal product should
be calculated according to the following formula:
…. mg veterinary medicinal average body weight (kg)
product/kg BW/day x of the animals to be treated = … mg veterinary
Average daily mixed feed intake /kg per animal medicinal product
per kg/ mixed feed
The mixing should be performed by an (authorised) feeding stuff manufacturer
with adequate mixing apparatus.
The intake of medicated feed depends on the clinical condition of the animals.
In order to obtain the correct dosage the concentration of tylosin may need to
be adjusted accordingly.
Should there be no clear response to treatment within 3 days the treatment
approach should be reconsidered.
Do not use in cases of hypersensitivity to the active substance, to other
macrolides or to any of the excipients.
Do not use where cross-resistance to other macrolides (MLS-resistance)is
suspected.
Do not use in animals vaccinated with tylosin-sensitive vaccines either at the
same
time or within 1 week previously.
Do not use in animals with hepatic disorders.
Do not use in horses. Danger of inflammation of the cecum.
Pigs:
Undetermined frequency (cannot be
estimated from available data)
- Diarrhoea, rectal prolapse
- Rectal oedema
- Pruritus, erythema
Reporting adverse events is important. It allows continuous safety monitoring of
a veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or its local
representative or the national competent authority via the national reporting
system. See the package leaflet for respective contact details.
None.

Special precautions for safe use in the target species:
Animals with acute infections may have a reduced feed intake and should be
treated with a suitable injectable veterinary medicinal product first.
Due to likely variability (time, geographical) in susceptibility of bacteria for
tylosin, bacteriological sampling and susceptibility testing are recommended.
Inappropriate use of the veterinary medicinal product may increase the
prevalence of bacteria resistant to tylosin and other macrolides.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals:
Tylosin may induce irritation. Macrolides, such a tylosin, may also cause
hypersensitivity (allergy) following injection, inhalation, ingestion or contact with
skin or eye. Hypersensitivity to tylosin may lead to cross reactions to other
macrolides and vice versa. Allergic reactions to these substances may
occasionally be serious and therefore direct contact should be avoided.
Personal protective equipment, consisting of overalls, safety glasses,
impervious gloves, and either a disposable half mask respirator conforming to
European Standard EN149 or a non-disposable respirator to European
Standard EN140 with a filter to EN143 should be worn during preparation of the
medicated feed. Wash hands after use.
In the event of accidental skin contact, wash thoroughly with soap and water. In
case of accidental eye contact, flush the eyes with plenty of clean, running
water.
Do not handle the veterinary medicinal product if you are allergic to ingredients
in the veterinary medicinal product.
If you develop symptoms following exposure, such as skin rash, you should
seek medical advice and show the physician this warning. Swelling of the face,
AN: 00403/2023Page 3 of 7
lips and eyes or difficulty in breathing are more serious symptoms and require
urgent medical attention.
Special precautions for the protection of the environment
Not applicable.
Lincosamides and aminoglycoside antibiotics antagonize the activity of tylosin.
Store in a dry place below 30°C. Do not refrigerate or freeze. Protect from frost.
Store in the original container in order to protect from light.
Meat & offal.
Pigs: Zero days.
Chickens (broilers and pullets): 1 day.
Not for use in birds producing eggs for human consumption.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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