POM-V Prescription Required

Nextmune Concentrate and Solvent for Suspension for Injection for Chickens

Active ingredient: Infectious bursal disease virus

Form

Injection

Species

Chickens

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/3075

What it's used for

In laboratory studies, it was observed that the vaccination with Nextmune can reduce weight loss after infection with vvIBDV as observed 10 days after infe...

Full indications, dosage and side effects ↓

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Clinical information

Nextmune Concentrate and Solvent for Suspension for Injection for Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

In laboratory studies, it was observed that the vaccination with Nextmune can reduce
weight loss after infection with vvIBDV as observed 10 days after infection.
Onset of immunity: expected from 21 days of age onwards depending on the initial MDA
level.
The immunisation is influenced by the natural decline of maternally derived antibodies
(MDA), and has been found to occur when MDA have reached appropriate release
level.
Laboratory and field trials have been carried out in birds with MDA titres of 2500-7900
ELISA units.
In vaccinated chicks the release of the vaccine virus (vaccine virus take) was observed
between 14-35 days of age in clinical trials.
Duration of immunity: up to 7 weeks of age.

AN: 01861/2025Page 4 of 7
Use sterile devices and equipment for reconstitution and for administration of the
vaccine.
Match the dose size of the vaccine and the sterile solvent according to the tables below.
In ovo administration
One single dose of 0.05 ml is injected into each 18-day-old embryonated broiler chicken
egg using in-ovo equipment. The vaccine is delivered to the amnion sac.
Proposed dilutions for administration:
Number of vaccine
ampoules
Solvent Volume of one
dose
4 x 2000 doses400 ml2 x 4000 doses400 ml4 x 4000 doses800 ml1 x 8000 doses400 ml2 x 8000 doses800 ml2 x 8000 + 1x 4000
doses
1000 ml3 x 8000 doses1200 ml4 x 8000 doses1600 ml
0.05 ml
Subcutaneous administration
One single injection of 0.2 ml per chick is applied at one day of age. Automatic syringe
is recommended to use. The vaccine is delivered under the skin of the neck.
Proposed dilutions for subcutaneous administration:
Number of vaccine
ampoules
Solvent Volume of one
dose
1 x 2000 doses400 ml2 x 2000 doses800 ml1 x 4000 doses800 ml3 x 2000 doses1200 ml1 x 8000 doses1600 ml
0.2 ml
Preparation of vaccine:
1. After matching the dose size of the vaccine with the solvent (Cevac Solvent Poultry)
size, quickly remove from liquid nitrogen container the exact number of ampoules
needed.
2. Draw up 2-5 ml of solvent into a 5-10 ml sterile syringe. Use at least 18 gauge
needles.
3. Thaw rapidly the contents of the ampoules by gentle agitation in water at 27-39°C.
4. As soon as they are completely thawed, open ampoules holding them at arm’s length
in order to prevent any risk of injury should the ampoule break.
5. Once the ampoule is open slowly draw up the content into the needle already
containing 2-5 ml solvent.
AN: 01861/2025Page 5 of 7
6. Transfer the suspension into the solvent bag. The diluted vaccine prepared as
described is mixed by gentle agitation.
7. Withdraw a portion of the diluted vaccine into the syringe to rinse ampoule. Remove
the washing from the ampoule and inject it gently into the solvent bag. Repeat it one
or two times.
8. The diluted vaccine prepared as described is mixed by gentle agitation so as to be
ready for use.
Repeat the operations in point 2-7 for the appropriate number of ampoules to be
thawed.
The reconstituted vaccine is orange to red, clear to opaque suspension. Insoluble
particles may be present.

Do not use in embryos or chickens from non-vaccinated parent flocks or having no MDA
against IBDV.

Chickens (broiler and embryonated eggs):
Very common
(>1 animal / 10 animals treated):
Bursa of Fabricius lymphocyte
depletion
1
Mild to moderate which is maximal at around 7 days after vaccine take. After further 7
days, this depletion decreases and is followed by lymphocyte repopulation and
regeneration of the bursa of Fabricius.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

Vaccinate healthy animals only.
Vaccinate only MDA positive chickens which have at least an average day-old MDA
level of 3200 ELISA units.

Special precautions for safe use in the target species:
Vaccinated chickens may excrete the vaccine strain up to 21 days following vaccination.
During this time, the contact of immunosuppressed and unvaccinated birds with
vaccinated chickens should be avoided.
Appropriate veterinary and husbandry measures should be taken to avoid spread of the
vaccine strain to susceptible birds. Vaccinate all the birds in a flock at the same time.
AN: 01861/2025Page 3 of 7
This product should only be used after it has been demonstrated that very virulent IBDV
strains are epidemiologically relevant in the area of vaccination.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Liquid nitrogen containers and vaccine should be handled by properly trained personnel
only.
Personal protective equipment consisting of protective gloves, spectacles and boots
should be worn when handling the veterinary medicinal product, before withdrawing
from liquid nitrogen, during the ampoule thawing and opening operations.
Frozen glass ampoules can explode during sudden temperature changes. Store and
use liquid nitrogen only in a dry and well-ventilated place. Inhalation of the liquid
nitrogen is dangerous.
Personnel involved in the treatment of vaccinated birds should use hygiene principles
and take particular care in handling litter from vaccinated chickens.
Special precautions for the protection of the environment:
Not applicable.

No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product therefore needs to be made on a case by case
basis.

Vaccine:
Store and transport frozen in liquid nitrogen (-196°C).
The liquid nitrogen containers must be checked regularly for liquid nitrogen level and
must be refilled as needed.
Solvent:
Store below 25C.
Do not freeze.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.