POM-V Prescription Required

Aftopur DOE

Active ingredient: Foot-and-mouth disease virus

Form

Injection

Species

Cattle Goats Pigs Sheep

Manufacturer

Boehringer Ingelheim Vetmedica GmbH

VMD MA No.

61700/3040

What it's used for

For the active immunisation of ruminants and pigs to reduce clinical signs and mortality following exposure to Foot-and-Mouth Disease virus. The onset of i...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Foot-and-mouth disease virus

1

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They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

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Clinical information

Aftopur DOE — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

For the active immunisation of ruminants and pigs to reduce clinical signs and
mortality following exposure to Foot-and-Mouth Disease virus.
The onset of immunity is 3 weeks (demonstrated by challenge). Immunity lasts 6
months in cattle and at least 4 weeks in pigs (see section 4.9 for recommended
vaccination program).

Dosages: Large ruminants 2ml; Small ruminants 1ml; Pigs 2ml.

Shake before use.
The vaccine is to be administered by the Intramuscular Route. The preferred site in
pigs is the neck, behind the ear, and, in ruminants, the area of the shoulder.
Primary Course of Vaccination for Pigs:
One injection starting at 8 weeks of age and followed by a second vaccination 4
weeks later.
Boosters for Pigs
Where there is a likelihood of challenge with Foot and Mouth Disease Virus pigs
should be vaccinated every four weeks to maintain epidemiologically-relevant
immunity.
Primary Course of Vaccination for Ruminants:
One injection starting at 2 weeks of age followed by a second vaccination 4 weeks
later.

Boosters for Ruminants:
Animals should be administered a booster vaccination every 6 months.
No studies have been carried out in animals with maternally-derived immunity. The
vaccine can be administered to seronegative pigs from 8 weeks of age and to
seronegative calves from 2 weeks of age.

Do not use in unhealthy animals.

Amended pages: January 2026
AN: 00972/2024

Vaccination in both cattle and pigs may be followed by a small local swelling usually
up to 0.5cm diameter at the site of injection and the detection of granulomas at the
site of injection at post mortem. Transient pyrexia may also be seen. The maximum
size of injection site reaction noted in an overdose safety study in cattle was
11.5cmx7.2cmx1.2cm. Histological examination of injection site reactions after
administration of a single dose or an overdose revealed sterile granulomas. The
duration of the histological lesions was not studied but they are likely to persist for
several months. Injection site sterile granulomas are seen in up to 50% of animals
following the second or subsequent administration of vaccine and these last for up to
14 days.

Amended pages: January 2026
AN: 00972/2024

None.

(i) Special precautions for use in animals
None.

(ii) Special precautions to be taken by the person administering the veterinary
medicinal product to animals
If the vaccine is accidentally injected into man, urgent medical attention is
necessary.
To the user:
This product contains mineral oil. Accidental injection/self injection may result
in severe pain and swelling, particularly if injected into a joint or finger, and in
rare cases could result in the loss of the affected finger if prompt medical
attention is not given.
If you are accidentally injected with this product, seek prompt medical advice
even if only a very small amount is injected and take the package leaflet with
you.
If pain persists for more than 12 hours after medical examination, seek
medical advice again.
To the doctor:
This product contains mineral oil. Even if small amounts have been injected,
accidental injection with this product can cause intense swelling, which may,
for example, result in ischaemic necrosis and even the loss of a digit. Expert,
PROMPT, surgical attention is required and may necessitate early incision and
irrigation of the injected area, especially where there is involvement of finger
pulp or tendon.

No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product. However, experience in the field suggests
that the vaccine may be used satisfactorily with a range of bacterial and viral
vaccines. A decision to use this vaccine before or after any other veterinary medicinal
product therefore needs to be made on a case by case basis.

Store and transport vaccine at 2-8
o
C. Do not freeze. Protect from light.

Zero days.
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group:
ATCvet code: QI02AA04
Inactivated Foot and Mouth Disease vaccine containing one or several appropriate
serotypes of Types O, A, C, Asia 1, SAT 1, SAT 2, SAT 3 in a double oil emulsion
adjuvant. The strains and antigen content of the vaccine are formulated to provide
epidemiologically-relevant immunity in vaccinated animals. Vaccination of animals
induces the production of antibodies that reduce clinical signs and mortality following
exposure to Foot and Mouth Disease virus.

Repeated administration to cattle under experimental conditions on 3 consecutive
occasions over a period of two months of maximum payload AFTOPUR DOE foot
and mouth disease vaccine containing 16µg of 146S antigen of each of four strains
per dose has been demonstrated not to induce titres of antibodies against the Non-
Structural proteins of the virus sufficient to result in the serum scoring positive in the
enzyme-linked immunoelectro-transfer blot analysis test for antibodies against Non-
Structural proteins (Manual of Standards for Diagnostic Tests and Vaccines [2001]
Foot and Mouth Disease, Chapter 2.1.1. Office International des Epizooties, Paris) in
contrast to animals infected with foot and mouth disease virus.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.