POM-V Prescription Required

Hipragumboro G97 Lyophilisate for Oral Suspension for Chickens

Active ingredient: Infectious bursal disease virus

Form

Tablet

Species

Chickens

Manufacturer

Laboratorios Hipra Sa

VMD MA No.

17533/3008

What it's used for

Onset of immunity: 14 days post vaccination. Duration of immunity: 43 days post vaccination.

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Hipragumboro G97 Lyophilisate for Oral Suspension for Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity: 14 days post vaccination.
Duration of immunity: 43 days post vaccination.

Administration route: Oral.
Break the vacuum inside the vial by inoculation of 10 ml of drinking water without
chlorine or disinfectants. Shake gently until complete resuspension of the freeze-dried
powder before administration.
Posology:
Serologically negative birds can be vaccinated from one day of age. The optimum age
for vaccination may be calculated using the level of maternal antibody in the chicks at
day old (Kouwenhoven’s formula) by testing at least 18 birds (preferably 24) of the
flock according to the following table. All birds should be given a single vaccination
only.
MEAN ELISA TITRE AT 1 DAY OF
AGE
OPTIMUM AGE FOR VACCINATION
(DAYS)
≤5001≤7502-3≤1 0004≤1 2505-6≤1 5007≤2 0009≤2 50011≤3 00012-13≤3 50014≤4 00015-16≤4 50017≤5 00018≤5 50019≤6 00020
Method of administration:
The volume of water for reconstitution depends on the age of the birds and the
management practice. Generally, 2 litres of water per 1 000 broilers for every day of
age are needed. Hence, 1 000 14 day broilers would need 28 litres of water to
reconstitute the 1 000 doses of vaccine. If the birds have higher or lower water
requirements, adjust the volumes accordingly.
The way in which this vaccine is administered is critical. The following management
considerations have been found to improve the vaccine intake:
Water should be withheld for 1-2 hours before vaccination to ensure that all
reconstituted vaccine is consumed within 1-2 hours.
For bell drinkers: go round the house emptying and cleaning the drinkers during the
water withholding period. Mix up the vaccine according to the recommendations and at
the end of the water withholding period go round all the drinkers and fill them with
water containing vaccine.
For nipple drinkers: a considerable amount of residual water may remain in the lines
after the water withholding period. It is recommended to drain the lines and load them
with water which contains vaccine before allowing the birds to have access to the
nipples. Mix up the vaccine and apply to the tank. Calculate the volume that is left in
the tank below the outlet valve and be sure to take this volume of water into account
when calculating the number of doses to be added.
Always make sure that there is food available when vaccinating (birds will not drink if
they have no food to eat). Turn on mains water when all the water containing vaccine
has been consumed.

Do not use in infected flocks showing clinical signs.

Chickens (Broilers):
Very common
(>1 animal / 10 animals treated):
Bursa of Fabricius lymphocyte depletion
1
The administration of a single dose causes lymphocyte depletion in the bursa of
Fabricius (in 50-75% of the follicles). Lymphocyte repopulation is observed from 14
days post vaccination onwards, at 28 days post vaccination there is still some
depletion remaining (5-25 % of follicles). This lymphocyte depletion does not result in
an immunosuppressive effect.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.

Use only in flocks with low levels of maternal antibodies (mean ELISA titres  500).
The optimum day of vaccination of broilers with maternal antibodies is calculated
according to the Kouwenhoven’s formula (see section 3.9.)
Due to its residual pathogenicity to the bursa the vaccine should be used only in areas
contaminated with vvIBDV, except for infected flocks showing clinical signs.
Vaccinate healthy animals only.

Special precautions for safe use in the target species:
The vaccine strain can spread to unvaccinated chickens. Special precautions should
be taken to avoid spreading of the vaccine strain to unvaccinated chickens.
Appropriate veterinary and husbandry measures should be taken to avoid spread of
the vaccine strain to susceptible species.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Wash and disinfect hands and equipment after use.
In case of accidental ingestion, contact with the eyes, or spillage onto skin seek,
medical advice immediately and show the package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Not applicable.

No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product. A decision to use this vaccine before or after
any other veterinary medicinal product therefore needs to be made on a case by case
basis.

Store and transport refrigerated (2 C – 8 C).
Protect from light.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.