POM-V Prescription Required

Hipragumboro CW Lyophilisate for Use in Drinking Water

Active ingredient: Infectious bursal disease virus

Form

Liquid

Species

Chickens

Manufacturer

Laboratorios Hipra SA

VMD MA No.

17533/5017

What it's used for

For active immunisation of chicken (broilers) with maternally derived antibodies (MDA ELISA breakthrough titre of 115) to prevent clinical signs and to red...

Full indications, dosage and side effects ↓

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Clinical information

Hipragumboro CW Lyophilisate for Use in Drinking Water — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

For active immunisation of chicken (broilers) with maternally derived antibodies
(MDA ELISA breakthrough titre of 115) to prevent clinical signs and to reduce loss
of weight and bursal damage caused by Gumboro Disease.
The onset of immunity is 14 days post vaccination.
The duration of immunity: 30 days post vaccination.

Administer one dose of the vaccine per chicken in the drinking water.
Most of the commercial chicks are hatched with maternal antibodies which might
neutralize the vaccine. Due to this fact it is required to calculate the proper
vaccination time. The optimum age for vaccination is calculated, after testing the
level of maternal antibodies of 18-20 chicks of the flock, by means of the Deventer
Formula.
According to this formula the optimum age of vaccination is as follows:
Optimum vaccination age =
{(Log2 IBD antibody ELISA titre of bird(%) - Log2 breakthrough titre of the vaccine)
x t0.5}
+ age at sampling + correction 0-4
IBD antibody ELISA titre of bird(%):
ELISA titre of the bird (at sampling) representing a certain percentage of the flock
that is desired to be susceptible to the vaccine at the time of the application
Breakthrough titre of the vaccine:
ELISA titre that the vaccine is able to breakthrough
t0.5:
Half-life time of the antibodies (ELISA titre) in the type of chickens being sampled
Age at sampling:
Age of the birds at sampling
Correction 0-4:
Extra days when the sampling was done at 0 to 4 days of age.
Reconstitution of the vaccine:
Open the vaccine vial and introduce 10 ml of drinking water without chlorine or
disinfectants. Shake gently until the complete reconstitution of the freeze-dried
powder is achieved.
Other alternative is to open the vial under the water. The empty vial should be
rinsed a couple of times to ensure the complete reconstitution of the vaccine.
Method of administration:
It is important to use clean cold water, free from chlorine and other disinfectants.
The volume of water for reconstitution of the vaccine depends on the daily water
consumption which is related with the age of the birds, the environment
temperature and the management practices.

Revised: November 2023
Divergence from NI MA following AN: 03686/2022
The volume of water should be adjusted to ensure that the vaccine solution is
consumed in 1 hour up to 2 hours the maximum.
If the birds have higher or lower water consumption times, adjust the volume
accordingly to ensure the proper water consumption time.
The following management practices should improve the vaccine intake:
Water should be withheld for 1-2 hours prior vaccination to increase the thirst of
the birds and ensure that all reconstituted vaccine is consumed within 1 to 2
hours.
Bell drinker vaccination: it is recommended to empty and clean the bell drinkers
during the water withholding period. When the water restriction period is finished
the vaccine is reconstituted as indicated previously and it is delivered to the birds.
Nipple drinker vaccination: a considerable amount of residual water might remain
in the lines after the water withholding period. It is recommended to drain the lines
and load them with the vaccine solution before allowing the birds to have access
to the nipples.
Always ensure that the feed is available when vaccinating. The birds will not drink
enough if they do not have access to feed.

None.

In very rare cases notable transient lymphocyte depletion can be observed in
birds on day 7 post-vaccination. The repopulation of the follicles by lymphocytes
starts after day 7 post-vaccination, being specially evident on 21 days post-
vaccination. By day 28 post-vaccination only mild lesions remain in some birds.
This does not result in an immune-supressive effect.
The frequency of adverse reactions is defined using the following convention:
Very common (more than 1 in 10 animals displaying adverse reaction(s) during
the course of one treatment).
-Common (more than 1 but less than 10 animals in 100 animals).
Uncommon (more than 1 but less than 10 animals in 1,000 animals).
Rare (more than 1 but less than 10 animals in 10,000 animals).
Very rare (less than 1 animal in 10,000 animals, including isolated reports).

The optimal day of vaccination is calculated according to the Deventer’s formula,
using 115 as the ELISA breakthrough titre value.

Revised: November 2023
Divergence from NI MA following AN: 03686/2022

Special precautions for use in animals
Vaccinate healthy animals only.
The vaccine strain is excreted up to a maximum of 10 days; thus, during this time,
it may spread to unvaccinated chickens.
Appropriate veterinary and husbandry measures should be taken to avoid cross
contamination of flocks.
Do not use drinking water with chlorine or disinfectants.
The vaccine should not be used in birds without maternally derived antibodies.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Personal protective equipment consisting of impervious gloves should be worn
when handling the product.
Wash and disinfect hands and equipment after use.
In case of accidental ingestion, contact with the eyes, or spillage onto the skin,
seek medical advice immediately and show the package leaflet or the label to the
physician.

interaction
No information is available on the safety and efficacy of this vaccine when used
with any other veterinary medicinal product. A decision to use this vaccine before
or after any other veterinary medicinal product therefore needs to be made on a
case by case basis.

Revised: November 2023
Divergence from NI MA following AN: 03686/2022

Store and transport refrigerated (2 ºC - 8 ºC).
Do not freeze.
Protect from light.

CCID50 (cell culture infective dose 50%).
For the full list of excipients, see section

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.