POM-V Prescription Required

Hipragumboro CW Lyophilisate for Use in Drinking Water

Active ingredient: Infectious bursal disease virus

Form

Liquid

Species

Chickens

Manufacturer

Laboratorios Hipra SA

VMD MA No.

17533/3002

What it's used for

Onset of immunity: 14 days post vaccination. Duration of immunity: 30 days post vaccination.

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Clinical information

Hipragumboro CW Lyophilisate for Use in Drinking Water — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity: 14 days post vaccination.
Duration of immunity: 30 days post vaccination.

Most of the commercial chicks are hatched with maternal derived antibodies,
which might neutralise the vaccine. Therefore, it is required to calculate the proper
vaccination time. The optimum age for vaccination is calculated by the Deventer
Formula, after testing the level of maternally derived antibodies of 18-20 chicks of
the flock.
According to this formula the optimum age of vaccination is as follows:
Optimum vaccination age =
{(Log2 IBD antibody ELISA titre of bird(%) - Log2 breakthrough titre of the vaccine)
x t0.5}
+ age at sampling + correction 0-4
IBD antibody ELISA titre of bird(%):
ELISA titre of the bird (at sampling) representing a certain percentage of the flock
that is desired to be susceptible to the vaccine at the time of the application
Breakthrough titre of the vaccine:
ELISA titre that the vaccine is able to breakthrough
t0.5:
Half-life time of the antibodies (ELISA titre) in the type of chickens being sampled
Age at sampling:
Age of the birds at sampling
Correction 0-4:
Extra days when the sampling was done at 0 to 4 days of age.
Reconstitution and method of administration:
Only clean, cold, fresh, antiseptic and disinfectant free drinking water should be
used for reconstitution of the vaccine.
Calculate the number of vials of vaccine required and the volume of water needed
to vaccinate all the birds.
The needed volume of water for reconstitution of the vaccine depends on the daily
water consumption which is related to the age of the birds, the environment
temperature and the management practices. The volume of water should be
adjusted to ensure that the vaccine solution is consumed in about 1 - 2 hours at
the latest. If the birds have higher or lower water consumption times, adjust the
volume accordingly to ensure the proper water consumption time.
Open the vaccine vial(s) and introduce 10 ml of water. Shake gently until the
lyophilisate is completely dissolved. The reconstituted vaccine is a pinkish
suspension. Transfer the suspension into a container containing the remaining
volume for the final vaccine suspension. The empty vial(s) should be rinsed a
couple of times to ensure the complete reconstitution of the vaccine.
Alternatively, fill a clean container with the appropriate amount of water, submerge
each of the closed vaccine vials individually and open the vial(s) under water.
Shake gently until the lyophilisate is completely dissolved. The empty vial should
be rinsed a couple of times to ensure the complete reconstitution of the vaccine.
The following management practices should improve the vaccine intake:
Water should be withheld for 1-2 hours prior vaccination to increase the thirst of
the birds and ensure that all reconstituted vaccine is consumed within 1 to 2
hours.
Bell drinker vaccination: it is recommended to empty and clean the bell drinkers
during the water withholding period. When the water restriction period is finished
the vaccine is reconstituted as indicated previously and it is delivered to the birds.
Nipple drinker vaccination: a considerable amount of residual water might remain
in the lines after the water withholding period. It is recommended to drain the lines
and load them with the vaccine solution before allowing the birds to have access
to the nipples.
Always ensure that the feed is available when vaccinating. The birds will not drink
enough if they do not have access to feed.

None.

Chickens.
Very rare
(< 1 animal / 10 000 animals
treated, including isolated
reports):
Bursa Fabricius lymphocyte depletion
1
a notable and transient lymphocyte depletion can be observed in birds on day 7
post-vaccination. The repopulation of the follicles by lymphocytes starts after day
7 post-vaccination, being especially evident on 21 days post-vaccination. By day
28 post-vaccination only mild lesions remain in some birds. This does not result in
an immune-supressive effect.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or its local representative
or the national competent authority via the national reporting system. See the
package leaflet for respective contact details.

Vaccinate healthy animals only.
The optimal day of vaccination is calculated according to the Deventer’s formula,
applying an ELISA titre of 115 as the MDA breakthrough titre.

Special precautions for safe use in the target species:
Vaccinated chickens may excrete the vaccine strain up to 10 days following
vaccination. During this time, the vaccine strain can spread to unvaccinated
chicken.
Appropriate veterinary and husbandry measures should be taken to avoid spread
of the vaccine strain to susceptible species.
The vaccine should not be used in birds without maternally derived antibodies
(MDA).
Special precautions to be taken by the person administering the veterinary
medicinal product to animals:
Personal protective equipment consisting of impervious gloves should be worn
when handling the veterinary medicinal product.
Wash and disinfect hands and equipment after use.
In case of accidental ingestion, contact with the eyes, or spillage onto the skin,
seek medical advice immediately and show the package leaflet or the label to the
physician.
Special precautions for the protection of the environment:
Not applicable.

interaction
No information is available on the safety and efficacy of this vaccine when used
with any other veterinary medicinal product. A decision to use this vaccine before
or after any other veterinary medicinal product therefore needs to be made on a
case by case basis.

Store and transport refrigerated (2 ºC - 8 ºC).
Do not freeze.
Protect from light.

Zero days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.