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Doxyveto 500 mg/g Powder for Use in Drinking Water/Milk Replacer for Cattle (pre-ruminant), Pigs, Chickens

Active ingredient: Doxycycline Hyclate

Form

Powder

Species

Cattle Chickens Pigs

Manufacturer

VMD NV

VMD MA No.

19968/4005

What it's used for

Cattle (pre-ruminant): - Bronchopneumonia and pleuropneumonia caused by Pasteurella spp, Streptococcus spp, Trueperella pyogenes, Histophilus somni and Myc...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Doxycycline Hyclate

1

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They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

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Prescription required

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Clinical information

Doxyveto 500 mg/g Powder for Use in Drinking Water/Milk Replacer for Cattle (pre-ruminant), Pigs, Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Cattle (pre-ruminant):
- Bronchopneumonia and pleuropneumonia caused by Pasteurella spp,
Streptococcus spp, Trueperella pyogenes, Histophilus somni and Mycoplasma spp..
Pigs:
- Atrophic rhinitis caused by Pasteurella multocida Bordetella bronchiseptica
- Bronchopneumonia caused by Pasteurella multocida, Streptococcus suis and
Mycoplasma hyorhinis;
- Pleuropneumonia caused by Actinobacillus pleuropneumoniae.
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Chickens:
- Respiratory infections caused by
paragallinarum and Bordetella avium;
- Enteritis caused by and Clostridium colinum.

administrations.
Pigs: 10 mg doxycycline hyclate/kg bw/day, equivalent to 20 mg
veterinary medicinal product per kg bw, during 3-5
consecutive days.
Chickens: 25 mg doxycycline hyclate/kg bw/day, equivalent to 50 mg
veterinary medicinal product per kg bw, during 3-5
consecutive days.
Based on the recommended dose and the number and weight of the animals to be
treated, the exact daily concentration of the veterinary medicinal product should be
calculated using the following formula:
mg veterinary medicinal product /
kg body weight per day
Xaverage body weight
(kg) of animals to be
treated
average daily water/milk intake (l/animal)
= .... mg veterinary
medicinal product
per litre of drinking
water/milk replacer
To ensure a correct dosage, body weight should be determined as accurately as
possible.
The intake of medicated water/milk replacer depends on the clinical condition of the
animals. In order to obtain the correct dosage, the concentration of doxycycline in the
drinking water/milk replacer possibly may need to be adjusted accordingly.
The use of suitably calibrated measuring equipment is recommended.
The daily amount is to be added to the drinking water in such manner that all
medication is taken up in 24 hours. Medicated drinking water should be freshly
prepared every 24 hours. Half the daily amount is to be added to milk replacer in
such manner that all medication is taken up in 2 hours. It is recommended to prepare
a concentrated stock solution - not exceeding 150 grams veterinary medical product
per litre of drinking water - and to dilute this further to therapeutic concentrations if
required.
Instead, the concentrated solution may also be used in a water-driven medicator for
proportional administration. Milk replacer: half the daily amount is to be added to milk
replacer in such manner that all medication is taken up in 2 hours.

Do not use in cases of hypersensitivity to the active substance, to tetracyclines or to
any of the excipients.
Do not use in animals with serious liver or kidney deficiency.
Do not use in ruminating cattle.

Cattle (pre-ruminant), pigs, chickens (broilers, breeders, replacement chicks)
Rare
(1 to 10 animals / 10 000
animals treated)
Allergic reaction
Photosensitivity
Gastrointestinaldisorder
If suspected adverse reactions occur, treatment should be discontinued and the
advice of a veterinarian should be sought.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

There is a high resistance rate documented against tetracyclines in E. coli isolated
from chickens. Therefore the product should only be used for the treatment of
infections caused by E. coli after susceptibility testing has been carried out.
Resistance to tetracyclines has also been reported in some EU countries in
pathogens of pigs (A. pleuropneumoniae, S. suis) and pathogens of calves
(Pasteurella spp.).

Special precautions for safe use in the target species:
As a result of a likely variation (in the course of time or geographically) in the
susceptibility of bacteria to doxycycline, bacteriological testing and susceptibility
testing of micro-organisms from diseased animals on a farm is strongly
recommended.
As complete elimination of the target pathogens may not be achieved, the medicinal
product should be combined with good management practices, such as good
hygiene, proper ventilation and no overstocking.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:

hypersensitivity reactions if contact is made with the skin or eyes (powder and
solution), or if the powder is inhaled.

contact with the veterinary medicinal product. Personal protective equipment
consisting of impermeable gloves (e.g. rubber or latex) and an appropriate dust
mask (e.g. disposable half-mask respirator conforming to European Standard
EN149) should be worn when handling the veterinary medicinal product.


clean water and if irritation occurs, seek medical advice.
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
medicinal product.

medical advice and show the package leaflet or the label to the physician.
Swelling of the face, lips or eyes, or difficulty with breathing are more serious
symptoms and require urgent medical attention.

Not to be administered in combination with bactericidal antibiotics, such as penicillins
and cephalosporins.
Tetracyclines may chelate cations (eg. Mg, Mn, Fe and Al) and this can lead to
reduced bioavailability.
The combination with mycotoxin-binding agents can lead to both increased and
decreased plasma concentrations of doxycycline and should therefore be avoided.
The presence of food in the gastrointestinal tract reduces the likelihood of such
interactions.
Commented [VHM1]: Adapted after EU comment PVAR3
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Bag:
Store below 25 °C.
Tightly reclose the bags after first opening in order to protect from light.
Protect the medicated drinking water from direct sunlight.
Jar:
Store below 25 °C.
Tightly reclose the jars after first opening in order to protect from light.
Protect the medicated drinking water from direct sunlight.
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Cattle (pre-ruminant):
Meat and offal: 7 days
Not authorised for use in animals producing milk for human consumption.
Pigs:
Meat and offal: 8 days
Chicken:
Meat and offal: 5 days
Not for use in birds producing or intended to produce eggs for human consumption.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.