Closiver 5 mg/ml + 125 mg/ml Solution for Injection for Sheep

Care should be taken to avoid the following practices because they increase the
risk of development of resistance and could ultimately result in ineffective therapy:

extended period of time.

misadministration of the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the tests strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
Resistance to ivermectin and closantel has been reported in
in sheep. Therefore the use of this product should be based on local
epidemiological information about the susceptibility of the
and recommendations on how to limit further selection for resistance to
anthelmintics.

Revised: September 2015
AN. 01215/2014
Resistance to macrocyclic lactones has been reported in in sheep
in a number of countries
In sheep treatment of psoroptic mange (sheep scab) with one injection of this
product will not be effective in eliminating all the mites. A suitable ivermectin–only
injectable product must be administered seven days after the treatment with this
product to treat clinical signs and to eliminate the mites.
Sheep scab (Psoroptes ovis) is an extremely contagious external parasite of sheep.
To ensure complete control great care must be taken to avoid re-infestation, as
mites may be viable for up to 15 days off the sheep. It is important that all sheep
which have been in contact with infected sheep are treated with an appropriate
product. Contact between treated, infected and untreated flocks must be avoided
until at least seven days after treatment.

i. Special precautions for use in animals
Avermectins may not be well tolerated in all non-target species (cases of
intolerance with fatal outcome are reported in dogs – especially Collies, Old
English Sheepdogs and related breeds or crosses, and also in
turtles/tortoises).
ii. Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Do not smoke, eat or drink while handling the product.
Direct contact of the product with the skin should be kept to a minimum. Wash
hands after use. Take care to avoid self-injection. Inadvertent self-injection
may result in local irritation and/or pain at the injection site.
accidental self-injection, seek medical advice immediately and show the label
or package leaflet to the physician