Closamectin Solution for Injection for Cattle

The veterinary medicinal product should be administered at a dosage rate of 200 µg
ivermectin per kg bodyweight and 5 mg closantel per kg bodyweight (1 ml per 25
kg). It should only be injected subcutaneously into the neck. A maximum dose of
10ml should be administered at any one site with any residual volume administered
at another site in the neck. A sterile 16-gauge, one-inch needle is recommended.
This product does not contain an antimicrobial preservative. Swab septum before
removing each dose. Use a dry sterile needle and syringe. For 250 ml and 500 ml
pack sizes, use of a multiple dose syringe is recommended. To refill the syringe,
use of a draw-off needle is recommended to avoid excessive broaching of the
stopper.
Do not exceed 40 broachings per vial. If more than 40 broachings are required, use
of a draw off needle is recommended.
The timing for treatment should be based on epidemiological factors and should be
customised for each individual farm. As with other anthelmintics, veterinary advice
should be sought on appropriate dosing programmes and stock management to

Revised: April 2025
AN: 01009/2023
achieve adequate parasite control and reduce the likelihood of resistance
developing.
To ensure administration of a correct dose, bodyweight should be determined as
accurately as possible; accuracy of the dosing device should be checked.
If animals are to be treated collectively rather than individually they should be
grouped according to their bodyweight and dosed accordingly, in order to avoid
under- or over-dosing.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Single doses of 4.0 mg/kg ivermectin (20 times the recommended dosage)
administered subcutaneously, result in ataxia and depression. No antidote has been
identified. Symptomatic treatment may be beneficial.
Closantel like other salicylanilides is a potent uncoupler of oxidative phosphorylation
and the safety index is not as high as is the case of many other anthelmintics.
However where used as directed there are unlikely to be any untoward effects.
Signs of overdosage can include loss of appetite, decreased vision, loose faeces
and increased frequency of defaecation. High doses may cause blindness,
hyperventilation, hyperthermia, general weakness, inco-ordination, convulsions,
tachycardia and in extreme cases death. Treatment of overdosage is symptomatic
as no antidote has been identified.
Oral closantel doses in excess of 82.5 mg/kg in cattle may cause blindness,
hyperventilation, hyperthermia, general weakness, in-coordination, convulsions,
tachycardia and in extreme cases death.
4.11 Withdrawal period(s)
Meat and offal: 49 days.
Milk: Not authorised for use in cattle producing milk for human consumption
including during the dry period. Do not use during the last trimester of pregnancy in
heifers which are intended to produce milk for human consumption.
5.