POM-VPS
Prescription Required
Closamectin 5 mg/ml/125 mg/ml Solution for Injection for Sheep
Active ingredients: Closantel, Ivermectin
Form
Injection
Species
Sheep
Manufacturer
Norbrook Laboratories Limited
VMD MA No.
02000/4262
What it's used for
For the treatment of mixed trematode (fluke) and nematode or arthropod infestations due to gastrointestinal roundworms, trematodes, lungworms, nasal bots a...
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Clinical information
Closamectin 5 mg/ml/125 mg/ml Solution for Injection for Sheep — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
For the treatment of mixed trematode (fluke) and nematode or arthropod
infestations due to gastrointestinal roundworms, trematodes, lungworms, nasal
bots and mites of sheep.
Gastrointestinal roundworms
Teladorsagia circumcincta
and L4), (including inhibited L4),
(adult),
curticei
venulosum (adult) (adult and L4)
L4), Trichuris ovis (adult).
[L4 = fourth stage larave]
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
Lungworms
Dictyocaulus filaria (adult and 4
th
stage larvae)
Protostrongylus rufescens (adult)
Liver Fluke (Adults and 7 weeks immature)
Fasciola gigantica, Fasciola hepatica
Nasal Bots
Oestrus ovis
Mange Mites
Psoroptes ovis
7 days later. See sections 4.4 and 4.9)
Benzimidazole – resistant strains of and
circumcincta
infestations due to gastrointestinal roundworms, trematodes, lungworms, nasal
bots and mites of sheep.
Gastrointestinal roundworms
Teladorsagia circumcincta
and L4), (including inhibited L4),
(adult),
curticei
venulosum (adult) (adult and L4)
L4), Trichuris ovis (adult).
[L4 = fourth stage larave]
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
Lungworms
Dictyocaulus filaria (adult and 4
th
stage larvae)
Protostrongylus rufescens (adult)
Liver Fluke (Adults and 7 weeks immature)
Fasciola gigantica, Fasciola hepatica
Nasal Bots
Oestrus ovis
Mange Mites
Psoroptes ovis
7 days later. See sections 4.4 and 4.9)
Benzimidazole – resistant strains of and
circumcincta
The veterinary medicinal product should be administered at a dosage rate of 200
g ivermectin per kg bodyweight and 5 mg closantel per kg bodyweight (1 ml per
25 kg). It should only be injected subcutaneously into the neck. A sterile 16-
gauge, one-inch needle is recommended.
This product does not contain an antimicrobial preservative. Swab septum before
removing each dose. Use a dry sterile needle and syringe. For 250 ml and 500 ml
pack sizes, use of a multiple dose syringe is recommended. To refill the syringe,
use of a draw-off needle is recommended to avoid excessive broaching of the
stopper. If more than 40 broachings are required, use of a draw off needle is
recommended.
The timing for treatment should be based on epidemiological factors and should be
customised for each individual farm. Professional veterinary advice should be
sought on appropriate dosing programmes and stock management to achieve
adequate parasite control and reduce the likelihood of resistance developing.
To ensure administration of a correct dose, bodyweight should be determined as
accurately as possible; accuracy of the dosing device should be checked.
If animals are to be treated collectively rather than individually they should be
grouped according to their bodyweight and dosed accordingly, in order to avoid
under- or overdosing.
For the treatment and control of sheep scab an injection of the veterinary
medicinal product may be administered but must be followed with a second
injection of an ivermectin only product seven days after the initial injection to treat
clinical signs of scab and to eliminate mites. This injection should be administered
at the other side of the neck.
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
g ivermectin per kg bodyweight and 5 mg closantel per kg bodyweight (1 ml per
25 kg). It should only be injected subcutaneously into the neck. A sterile 16-
gauge, one-inch needle is recommended.
This product does not contain an antimicrobial preservative. Swab septum before
removing each dose. Use a dry sterile needle and syringe. For 250 ml and 500 ml
pack sizes, use of a multiple dose syringe is recommended. To refill the syringe,
use of a draw-off needle is recommended to avoid excessive broaching of the
stopper. If more than 40 broachings are required, use of a draw off needle is
recommended.
The timing for treatment should be based on epidemiological factors and should be
customised for each individual farm. Professional veterinary advice should be
sought on appropriate dosing programmes and stock management to achieve
adequate parasite control and reduce the likelihood of resistance developing.
To ensure administration of a correct dose, bodyweight should be determined as
accurately as possible; accuracy of the dosing device should be checked.
If animals are to be treated collectively rather than individually they should be
grouped according to their bodyweight and dosed accordingly, in order to avoid
under- or overdosing.
For the treatment and control of sheep scab an injection of the veterinary
medicinal product may be administered but must be followed with a second
injection of an ivermectin only product seven days after the initial injection to treat
clinical signs of scab and to eliminate mites. This injection should be administered
at the other side of the neck.
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
Do not use by intramuscular or intravenous route.
Do not use in animals with known hypersensitivity to the active substance(s) or to
any of the excipient(s).
Avermectins may not be well tolerated in all non-target species (cases of
intolerance with fatal outcome are reported in dogs – especially Collies, Bobtails,
Old English Sheepdogs and related breeds or crosses, and also in
turtles/tortoises).
Please refer to Section 4.7 and 4.8 of the SPC.
Do not use in animals with known hypersensitivity to the active substance(s) or to
any of the excipient(s).
Avermectins may not be well tolerated in all non-target species (cases of
intolerance with fatal outcome are reported in dogs – especially Collies, Bobtails,
Old English Sheepdogs and related breeds or crosses, and also in
turtles/tortoises).
Please refer to Section 4.7 and 4.8 of the SPC.
Transitory swelling has rarely been observed in sheep at the injection site and
occasionally this swelling is accompanied by pain and discomfort. This swelling
resolves completely within 14 days following treatment.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated
reports)
occasionally this swelling is accompanied by pain and discomfort. This swelling
resolves completely within 14 days following treatment.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated
reports)
Care should be taken to avoid the following practices because they increase the
risk of development of resistance and could ultimately result in ineffective therapy:
•
extended period of time.
•
misadministration of the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the tests strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
Resistance to ivermectin and closantel has been reported in
contortus in sheep. Therefore the use of this product should be based on local
epidemiological information about the susceptibility of the
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
and recommendations on how to limit further selection for resistance to
anthelmintics.
In sheep treatment of psoroptic mange (sheep scab) with one injection of this
product will not be effective in eliminating all the mites. A suitable ivermectin–only
injectable product must be administered seven days after the treatment with this
product to treat clinical signs and to eliminate the mites.
Sheep scab (Psoroptes ovis) is an extremely contagious external parasite of
sheep. To ensure complete control great care must be taken to avoid re-
infestation, as mites may be viable for up to 15 days off the sheep. It is important
that all sheep which have been in contact with infected sheep are treated with an
appropriate product. Contact between treated, infected and untreated flocks must
be avoided until at least seven days after treatment.
Special precautions for use in animals
Not applicable.
Special precautions to be taken by the person administering the medical veterinary
product to animals
Do not smoke, eat or drink while handling the product.
Avoid direct contact of the product with the skin. In case of spillage onto the skin
rinse immediately with fresh water.
Wash hands after use. Take care to avoid self-injection. Inadvertent self-injection
may result in local irritation and/or pain at the injection site. In case of accidental
self-injection, seek medical advice immediately and show the package leaflet to
the physician.
Other Precautions
Ivermectin is very toxic to aquatic organisms and dung insects. Long term effects
on dung insects caused by continuous or repeated use cannot be excluded.
Therefore, repeated treatment of animals on a pasture with an ivermectin-
containing product within a season should only be given in the absence of
alternative treatments or approaches to maintain animal/flock health, as advised
by a veterinarian.
risk of development of resistance and could ultimately result in ineffective therapy:
•
extended period of time.
•
misadministration of the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the tests strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
Resistance to ivermectin and closantel has been reported in
contortus in sheep. Therefore the use of this product should be based on local
epidemiological information about the susceptibility of the
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
and recommendations on how to limit further selection for resistance to
anthelmintics.
In sheep treatment of psoroptic mange (sheep scab) with one injection of this
product will not be effective in eliminating all the mites. A suitable ivermectin–only
injectable product must be administered seven days after the treatment with this
product to treat clinical signs and to eliminate the mites.
Sheep scab (Psoroptes ovis) is an extremely contagious external parasite of
sheep. To ensure complete control great care must be taken to avoid re-
infestation, as mites may be viable for up to 15 days off the sheep. It is important
that all sheep which have been in contact with infected sheep are treated with an
appropriate product. Contact between treated, infected and untreated flocks must
be avoided until at least seven days after treatment.
Special precautions for use in animals
Not applicable.
Special precautions to be taken by the person administering the medical veterinary
product to animals
Do not smoke, eat or drink while handling the product.
Avoid direct contact of the product with the skin. In case of spillage onto the skin
rinse immediately with fresh water.
Wash hands after use. Take care to avoid self-injection. Inadvertent self-injection
may result in local irritation and/or pain at the injection site. In case of accidental
self-injection, seek medical advice immediately and show the package leaflet to
the physician.
Other Precautions
Ivermectin is very toxic to aquatic organisms and dung insects. Long term effects
on dung insects caused by continuous or repeated use cannot be excluded.
Therefore, repeated treatment of animals on a pasture with an ivermectin-
containing product within a season should only be given in the absence of
alternative treatments or approaches to maintain animal/flock health, as advised
by a veterinarian.
Do not administer concomitantly with chlorinated compounds. The effect of GABA
agonists are increased by ivermectin.
agonists are increased by ivermectin.
Do not store above 25°C.
Protect from light.
Protect from light.
Do not administer concomitantly with chlorinated compounds. The effect of GABA
agonists are increased by ivermectin.
4.9 Amounts to be administered and administration route
The veterinary medicinal product should be administered at a dosage rate of 200
g ivermectin per kg bodyweight and 5 mg closantel per kg bodyweight (1 ml per
25 kg). It should only be injected subcutaneously into the neck. A sterile 16-
gauge, one-inch needle is recommended.
This product does not contain an antimicrobial preservative. Swab septum before
removing each dose. Use a dry sterile needle and syringe. For 250 ml and 500 ml
pack sizes, use of a multiple dose syringe is recommended. To refill the syringe,
use of a draw-off needle is recommended to avoid excessive broaching of the
stopper. If more than 40 broachings are required, use of a draw off needle is
recommended.
The timing for treatment should be based on epidemiological factors and should be
customised for each individual farm. Professional veterinary advice should be
sought on appropriate dosing programmes and stock management to achieve
adequate parasite control and reduce the likelihood of resistance developing.
To ensure administration of a correct dose, bodyweight should be determined as
accurately as possible; accuracy of the dosing device should be checked.
If animals are to be treated collectively rather than individually they should be
grouped according to their bodyweight and dosed accordingly, in order to avoid
under- or overdosing.
For the treatment and control of sheep scab an injection of the veterinary
medicinal product may be administered but must be followed with a second
injection of an ivermectin only product seven days after the initial injection to treat
clinical signs of scab and to eliminate mites. This injection should be administered
at the other side of the neck.
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Dose levels approaching 4.0 mg/kg ivermectin (20 times the recommended
dosage) administered subcutaneously, result in ataxia and depression in sheep.
Closantel like other salicylanilides is a potent uncoupler of oxidative
phosphorylation and the safety index is not as high as is the case of many other
anthelmintics. However where used as directed there are unlikely to be any
untoward effects. Signs of overdosage can include loss of appetite, decreased
vision, loose faeces and increased frequency of defaecation. High doses may
cause blindness, hyperventilation, hyperthermia, general weakness, inco-
ordination, convulsions, tachycardia and in extreme cases death.
No antidote has been identified for either ivermectin or closantel overdosage.
Symptomatic treatment may be beneficial.
The lethal dose (LD50) of closantel in sheep, after a single intramuscular dose, was
higher than 40 mg/kg. Moreover, some studies conducted in sheep reported signs
of overdose with doses of around 4 times the therapeutic dose (both injectable and
oral).
4.11 Withdrawal Period(s)
Meat and offal: 28 days.
Milk: Not authorised for use in ewes producing milk for human consumption
including during the dry period. Do not use within 1 year prior to the first lambing
in ewes intended to produce milk for human consumption.
5.
agonists are increased by ivermectin.
4.9 Amounts to be administered and administration route
The veterinary medicinal product should be administered at a dosage rate of 200
g ivermectin per kg bodyweight and 5 mg closantel per kg bodyweight (1 ml per
25 kg). It should only be injected subcutaneously into the neck. A sterile 16-
gauge, one-inch needle is recommended.
This product does not contain an antimicrobial preservative. Swab septum before
removing each dose. Use a dry sterile needle and syringe. For 250 ml and 500 ml
pack sizes, use of a multiple dose syringe is recommended. To refill the syringe,
use of a draw-off needle is recommended to avoid excessive broaching of the
stopper. If more than 40 broachings are required, use of a draw off needle is
recommended.
The timing for treatment should be based on epidemiological factors and should be
customised for each individual farm. Professional veterinary advice should be
sought on appropriate dosing programmes and stock management to achieve
adequate parasite control and reduce the likelihood of resistance developing.
To ensure administration of a correct dose, bodyweight should be determined as
accurately as possible; accuracy of the dosing device should be checked.
If animals are to be treated collectively rather than individually they should be
grouped according to their bodyweight and dosed accordingly, in order to avoid
under- or overdosing.
For the treatment and control of sheep scab an injection of the veterinary
medicinal product may be administered but must be followed with a second
injection of an ivermectin only product seven days after the initial injection to treat
clinical signs of scab and to eliminate mites. This injection should be administered
at the other side of the neck.
Revised: February 2023
AN: 01189/2022, 01191/2022, 01193/2022 & 01935/2022
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Dose levels approaching 4.0 mg/kg ivermectin (20 times the recommended
dosage) administered subcutaneously, result in ataxia and depression in sheep.
Closantel like other salicylanilides is a potent uncoupler of oxidative
phosphorylation and the safety index is not as high as is the case of many other
anthelmintics. However where used as directed there are unlikely to be any
untoward effects. Signs of overdosage can include loss of appetite, decreased
vision, loose faeces and increased frequency of defaecation. High doses may
cause blindness, hyperventilation, hyperthermia, general weakness, inco-
ordination, convulsions, tachycardia and in extreme cases death.
No antidote has been identified for either ivermectin or closantel overdosage.
Symptomatic treatment may be beneficial.
The lethal dose (LD50) of closantel in sheep, after a single intramuscular dose, was
higher than 40 mg/kg. Moreover, some studies conducted in sheep reported signs
of overdose with doses of around 4 times the therapeutic dose (both injectable and
oral).
4.11 Withdrawal Period(s)
Meat and offal: 28 days.
Milk: Not authorised for use in ewes producing milk for human consumption
including during the dry period. Do not use within 1 year prior to the first lambing
in ewes intended to produce milk for human consumption.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Same active ingredient
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