Advantage 250 mg Spot-on Solution for Large Dogs

Special warnings:
If signs of disease persist or appear, consult a veterinary surgeon.
Re-infestation from emergence of new fleas in the environment may continue
to occur for six weeks or longer after treatment is initiated. To aid reduction in
environmental challenge, the additional use of a suitable environmental
treatment against adult fleas and their developing stages is recommended. In
order to reduce further the environmental challenge, it is recommended that
all dogs, cats and rabbits in the household are treated, as necessary, with an
appropriate product. Treatment of nursing bitches controls flea infestations on
both dam and offspring.
The veterinary medicinal product remains effective if the animal becomes wet,
for example after exposure to heavy rain or after swimming. However, re-
treatment may become necessary, depending on the presence of fleas in the
environment. In these cases do not treat more frequently than once weekly.
Unnecessary use of antiparasitics or use deviating from the instructions given
in the SPC may increase the resistance selection pressure and lead to
reduced efficacy. The decision to use the product should be based on
confirmation of the parasitic species and burden, or of the risk of infestation
based on its epidemiological features, for each individual animal.
The possibility that other animals in the same household can be a source of
re-infection with biting lice should be considered, and these should be treated
as necessary with an appropriate product.

Special precautions for safe use in the target species:
This veterinary medicinal product is for topical use and should not be
administered orally.
Care should be taken to avoid the contents of the tube coming into contact
with the eyes or mouth of the recipient animal.
Do not allow recently treated animals to groom each other.

Amended pages: February 2026
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product contains benzyl alcohol and may cause skin sensitisation or
transient skin reactions (for example, irritation, tingling).
Do not get the product on your skin or in your eyes or mouth.
If you get the product on your skin, wash it off with soap and water.
If you get the product in your eyes, wash your eyes thoroughly with clean
water.
If the product causes any irritation to your skin or eyes that is persistent,
contact your doctor.
If the product is swallowed, contact your doctor immediately. Do not eat, drink
or smoke whilst using this product.
Wash hands thoroughly after use.
After application, do not stroke or groom animals until application site is dry.
Special precautions for the protection of the environment:
Imidacloprid is toxic to aquatic organisms. To avoid adverse effects on aquatic
organisms, treated dogs should not be allowed to enter surface water for 48
hours after treatment.
Other precautions:
The solvent in this veterinary medicinal product may stain or damage certain
materials including leather, fabrics, plastics and finished surfaces. Allow
application site to dry before permitting contact with such materials.