Advantage 100 mg Spot-on Solution for Medium Dogs

Special warnings:
If signs of disease persist or appear, consult a veterinary surgeon.
Re-infestation from emergence of new fleas in the environment may continue to
occur for six weeks or longer after treatment is initiated. To aid reduction in
environmental challenge, the additional use of a suitable environmental treatment
against adult fleas and their developing stages is recommended. In order to
reduce further the environmental challenge, it is recommended that all dogs, cats
and rabbits in the household are treated, as necessary, with an appropriate
product. Treatment of nursing bitches controls flea infestations on both dam and
offspring.
The veterinary medicinal product remains effective if the animal becomes wet, for
example after exposure to heavy rain or after swimming. However, re-treatment
may become necessary, depending on the presence of fleas in the environment.
In these cases do not treat more frequently than once weekly.
Unnecessary use of antiparasitics or use deviating from the instructions given in
the SPC may increase the resistance selection pressure and lead to reduced
efficacy. The decision to use the product should be based on confirmation of the
parasitic species and burden, or of the risk of infestation based on its
epidemiological features, for each individual animal.
The possibility that other animals in the same household can be a source of re-
infection with biting lice should be considered, and these should be treated as
necessary with an appropriate product.

Special precautions for safe use in the target species:
This veterinary medicinal product is for topical use and should not be
administered orally.
Care should be taken to avoid the contents of the tube coming into contact with
the eyes or mouth of the recipient animal.
Do not allow recently treated animals to groom each other.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product contains benzyl alcohol and may cause skin sensitisation or
transient skin reactions (for example, irritation, tingling).
Do not get the product on your skin or in your eyes or mouth.
If you get the product on your skin, wash it off with soap and water.
If you get the product in your eyes, wash your eyes thoroughly with clean water.

Amended pages: February 2026
If the product causes any irritation to your skin or eyes that is persistent, contact
your doctor.
If the product is swallowed, contact your doctor immediately. Do not eat, drink or
smoke whilst using this product.
Wash hands thoroughly after use.
After application, do not stroke or groom animals until application site is dry.
Special precautions for the protection of the environment:
Imidacloprid is toxic to aquatic organisms. To avoid adverse effects on aquatic
organisms, treated dogs should not be allowed to enter surface water for 48
hours after treatment.
Other precautions:
The solvent in this veterinary medicinal product may stain or damage certain
materials including leather, fabrics, plastics and finished surfaces. Allow
application site to dry before permitting contact with such materials.