Closamectin Solution for Injection for Cattle

Care should be taken to avoid the following practices because they increase the risk of
development of resistance and could ultimately result in ineffective therapy:
Too frequent and repeated use of anthelmintics from the same class, over an extended
period of time.
Underdosing which may be due to underestimation of bodyweight, misadministration of
the product, or lack of calibration of the dosing device.
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of the
tests strongly suggest resistance to a particular anthelmintic, an anthelmintic belonging to
another pharmacological class and having a different mode of action should be used.
Resistance to ivermectin has been reported in
of this product should be based on local epidemiological information about the
susceptibility of the
for resistance to anthelmintics.

Special precautions for safe use in the target species:
Not Applicable.
Special precautions to be taken by the person administering the medical veterinary
product to animals
Do not smoke, eat or drink while handling the product.
Avoid direct contact of the product with the skin. In case of spillage onto the skin rinse
immediately with fresh water.
Wash hands after use.
Take care to avoid self-injection. Inadvertent self-injection may result in local irritation
and/or pain at the injection site.
In case of accidental self-injection, seek medical advice immediately and show the
package leaflet or the label to the physician.
Special precautions for the protection of the environment:
Ivermectin is very toxic to aquatic organisms and dung insects. Treated cattle should not
have direct access to ponds, streams or ditches for 14 days after treatment. Long term
effects on dung insects caused by continuous or repeated use cannot be excluded.
Therefore repeated treatment of animals on a pasture with an ivermectin-containing
product within a season should only be given in the absence of alternative treatments or
approaches to maintain animal/herd health, as advised by a veterinarian.