Virbamec Pour-on Solution for Cattle 5 mg/ml

Care should be taken to avoid the following practices because they increase the risk
of the development of resistance and could ultimately result in ineffective therapy:
•
extended period of time.
•
misadministration of the product, or lack of calibration of the dosing device (if
any).
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used.
Resistance to ivermectin (an avermectin) has been reported in
in cattle within the EU, in in cattle in developed countries such as New
Zealand and in cattle outside the EU. Therefore the use of this product
should be based on local (regional, farm) epidemiological information about
susceptibility of nematodes and recommendations on how to limit further selection for
resistance to anthelmintics.

Special precautions for safe use in the target species:
Do not apply to areas of skin which have mange scabs or other lesions or to areas
contaminated with mud or manure.
Cattle should not be treated when the hair or hide is wet. Rain falling on animals less
than two hours after dosing may result in reduced efficacy. However, under such
conditions efficacy of veterinary medicinal product against infections of
ostertagi or in cattle may be maintained. The influence of
extreme weather conditions on the long-term performance (persistent activity) of
veterinary medicinal product is not known.
Frequent and repeated use may lead to the development of resistance.
The product is effective in all hypodermosis stages, however, it is very important to
treat on time (at the end of warble fly season). The elimination of Hypoderma
may cause negative reactions on the host, when they are found in vital areas. Killing
Hypoderma lineatum, if found in perioesophageal tissue, may cause salivation and
tympanism. Killing Hypoderma bovis, if found in the vertebral canal, may cause
unsteadiness or paralysis. Cattle should be treated before or after those stages of
warble flies.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
The veterinary medicinal product may be irritating to human skin and eyes and the
user should be careful not to apply it to himself or other persons. Personal protective
clothing consisting of nitrile rubber gloves, rubber boots and a waterproof coat should
be worn when handling the veterinary medicinal product.
Protective clothing should be washed after use.
In case of accidental spillage onto skin, wash the affected area immediately with
soap and water. In case of accidental eye exposure, flush the eyes immediately with
water and seek medical advice and show the package leaflet or the label to the
physician.
Do not smoke or eat while handling the product.
Wash hands after use.
Use only in well ventilated areas or outdoors.
Highly flammable.
Special precautions for the protection of the environment:
Not applicable.
Other precautions:
Avermectins may not be well tolerated in all non-target species. Cases of intolerance
with fatal outcome are reported in dogs, especially Collies, Old English Sheepdogs
and related breeds or crosses, and also in turtles/tortoises.