Animec 0.8mg/ml Oral Solution for Sheep

Care should be taken to avoid the following practices because they increase the
risk of development of resistance and could ultimately result in ineffective therapy:
• Too frequent and repeated use of anthelmintics from the same class, over
an extended period of time.
• Underdosing, which may be due to underestimation of body weight or
misadministration of the product.
 
Resistance to ivermectin (an avermectin) has been reported in Teladorsagia in
sheep and goats within the EU and it is common in Haemonchus in sheep outside
the EU. Therefore the use of this product should be based on local (regional,
farm) epidemiological information about susceptibility of nematode and
recommendations on how to limit further selection for resistance to anthelmintics.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g. Faecal Egg Count Reduction Test).
Where the results of the test(s) strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
There is cross-resistance with other avermectins and with milbemycins.

i. Special precautions for use in animals
The timing of treatment should be based on epidemiological factors and
should be customised for each individual farm. A dosing programme should
be established by the veterinary surgeon.
Veterinary advice should be sought on appropriate dosing programmes and
stock management to achieve adequate parasite control, and to reduce the
likelihood of anthelmintic resistance developing. Veterinary advice should
also be sought if the product does not achieve the desired clinical effect, as
other diseases, nutritional disturbances or anthelmintic resistance might be
involved.
Avermectins may not be well tolerated in non-target species. Cases of
intolerance resulting in fatalities have been reported in dogs, especially
Collies, Old English Sheep Dogs and related breeds or crosses, and also in
turtles/tortoises.

Revised: October 2014
AN: 00740/2014
ii. Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Wash hands after use. Avoid contact with skin and eyes.
Do not eat, drink or smoke while handling the product.
Wear impervious gloves when handling or administering the product.
As absorption through skin can occur, in the event of accidental skin
contact, wash the affected area immediately with soap and water.
If accidental eye exposure occurs, flush the eyes immediately with water.
iii. Other precautions
None known.