Animec 10 mg/ml Solution for Injection for Cattle, Pigs and Sheep

In sheep treatment of psoroptic mange (sheep scab) with one injection is not
recommended because, although a clinical improvement may be seen, elimination of all
mites may not occur.
Sheep scab (Psoroptes ovis) is an extremely contagious external parasite of sheep. To
ensure complete control great care must be taken to avoid re–infestation, as mites may be
viable for up to 15 days off the sheep. It is important that all sheep which have been in
contact with infected sheep are treated. Contact between treated, infected and untreated
flocks must be avoided until at least seven days after treatment.
Unnecessary use of antiparasitics or use deviating from the instructions given in the SPC
may increase the resistance selection pressure and lead to reduced efficacy. The decision
to use the product should be based on confirmation of the parasitic species and burden, or
of the risk of infestation based on its epidemiological features, for each herd or flock.
Repeated use for an extended period, particularly when using the same class of
substances, increases the risk of resistance development. Within a herd or flock,
maintenance of susceptible refugia is essential to reduce that risk. Systematically applied
interval-based treatment and treatment of a whole herd or flock should be avoided.
Instead, if feasible, only selected individual animals or subgroups should be treated
(targeted selective treatment). This should be combined with appropriate husbandry and
pasture management measures. Guidance for each specific herd/flock should be sought
from the responsible veterinarian.
Resistance to ivermectin has been reported in in
cattle. in cattle outside the
EU.
In sheep, resistance to ivermectin is widespread in ,
Trichostrongylus spp.,
species.
Multiple resistance was reported in to benzimidazoles,
macrocyclic lactones and levamisole and in
benzimidazoles.
Multiple resistance to macrocyclic lactones has also been reported in scab
mites in sheep and in cattle.
The use of this product should take into account local information about susceptibility of the
target parasites, where available. It is recommended to further investigate cases of
suspected resistance, using an appropriate diagnostic method (e.g. Faecal Egg Count

Amended pages: November 2025
AN: 01686/2025
Reduction Test). Confirmed resistance should be reported to the marketing authorisation
holder or to the competent authorities.

Special precautions for use in animals
In cattle, to avoid secondary reactions due to the death of Hypoderma larvae in the
oesophagus or in the spine it is recommended to administer the product at the end of warble
fly activity and before the larvae reach their resting sites. Consult your veterinarian on the
correct timing of treatment.
Avermectins may not be well tolerated in non-target species. Cases of intolerance with fatal
results are reported in dogs – especially Collies, Old English Sheepdogs and related breeds
and crosses, and also in turtles/tortoises. In addition, care should be taken to avoid ingestion
of spilled product or access to used containers by these other species.
Since ivermectin is highly bound to plasma proteins, special care should be taken in cases
of sick animals or in nutritional conditions associated with low plasma protein levels.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
This product may cause eye and skin irritation. Avoid contact with skin or eyes. In case of
skin or eye contact, wash exposed area with plenty of clean water. If symptoms persist,
seek medical advice.
Take care to avoid accidental self-injection: the product may cause local irritation and/or
pain at the site of injection. In case of accidental self-injection, seek immediate medical
advice and show the information leaflet or the label to the physician.
Do not eat or smoke while handling the product.
Wash hands after use.
Other precautions
The product is very toxic to aquatic organisms and dung insects.
Long term effects on dung insects caused by continuous or repeated use cannot be
excluded therefore repeated treatment of animals on a pasture with an ivermectin-
containing product within a season should only be given in the absence of alternative
treatments or approaches to maintain animal/flock health, as advised by a veterinarian.
Treated cattle should not have direct access to ponds, streams or ditches for 14 days after
treatment.