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AVM-GSL Over the Counter Companion Animal

VetUK Flea and Tick Treatment for Large Dogs 268 mg Spot-on Solution (Fipronil)

Active ingredient: Fipronil

Form

Spot-on

Species

Dogs

Manufacturer

Alfamed

VMD MA No.

17902/4044

What it's used for

Treatment of flea (Ctenocephalides spp.) and tick (Dermacentor ) infestations. Insecticidal efficacy against new infestations with adult fleas persists for...

Full indications, dosage and side effects ↓
View official SPC (PDF)

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Paying less for Fipronil

  1. 1

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    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Clinical information

VetUK Flea and Tick Treatment for Large Dogs 268 mg Spot-on Solution (Fipronil) — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Treatment of flea (Ctenocephalides spp.) and tick (Dermacentor )
infestations.
Insecticidal efficacy against new infestations with adult fleas persists for up to 8
weeks.
The product has a persistent acaricidal efficacy for up to 4 weeks against ticks
(Rhipicephalus sanguineus, ). If ticks of some
species (Rhipicephalus sanguineus and ) are present when the product
is applied, all the ticks may not be killed within the first 48 hours but they may be
killed within a week.
Route of administration and dosage:
External use only.
Administer by topical application to the skin according to the bodyweight as follows:
1 pipette of 2.68 ml per dog weighing over 20 kg and up to 40 kg bodyweight.
Method of administration:
Thermoformed pipettes:
Hold the pipette upright. Tap the narrow part of the pipette to ensure that the contents
are within the main body of the pipette. Break the snap-off top of the spot-on pipette
along the scored line.
Part the pet’s coat until its skin is visible. Place the tip of the pipette directly against
the bared skin and squeeze gently several times to empty its contents Repeat this
procedure at one or two different points along the pet’s back.
(Note: the shape of the marketed pipettes can be different as well as the pictures on
the marketed boxes/package leaflets.)

Revised: August 2018
AN: 00038/2018Page 5 of 7
Polypropylene pipettes:
Remove the pipette from the blister packaging. Hold the pipette in an upright position,
twist and pull the cap off. Turn the cap around and place the other end of the cap
back on the pipette. Twist the cap to break the seal, then remove the cap from the
pipette.
Part the pet’s coat until its skin is visible. Place the tip of the pipette directly against
the bared skin and squeeze gently several times to empty its contents. Repeat this
procedure at one or two points along the pet’s back.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off, and to make sure that animals do not lick each other following
treatment.
Care should be taken to avoid excessive wetting of the hair with the product since
this will cause a sticky appearance of hairs at the treatment spot. However, should
this occur, it will disappear within 24 hours post application.
Treatment schedule:
For optimal control of flea and/or tick infestation the treatment schedule can be based
on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Do not use on puppies less than 2 months old and /or weighing less than 2kg in the
absence of available data.
Do not use on sick (e.g. systemic diseases, fever…) or convalescent animals.
Do not use in rabbits, due to a risk of adverse drug reactions or even death.
This product is specifically developed for dogs. Do not use in cats, as this could lead
to overdosing.

Revised: August 2018
AN: 00038/2018Page 2 of 7
Do not use in known cases of hypersensitivity to the active substance or to any of the
excipients.
If licking occurs, a brief period of hypersalivation may be observed due mainly to the
nature of the carrier.
Very rarely transient cutaneous reactions on the application site (skin discoloration,
local alopecia, pruritus, erythema) and general pruritus or alopecia have been
reported after use. Hypersalivation, reversible neurologic symptoms (hyperesthesia,
depression, nervous symptoms), vomiting or respiratory symptoms have also been
observed very rarely after use.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals treated displaying adverse reaction(s))
- common (more than 1 but less than 10 animals in 100 animals treated)
- uncommon (more than 1 but less than 10 animals in 1,000 animals treated)
- rare (more than 1 but less than 10 animals in 10,000 animals treated)
- very rare (less than 1 animal in 10,000 animals treated, including isolated
reports).
Shampooing an hour prior to treatment does not affect the efficacy of the product
against fleas.
Bathing/immersion in water within two days after application of the product should be
avoided.
insecticidal efficacy against fleas by one week.
The product does not prevent ticks from attaching to the animals. If the animal has
been treated prior to exposure to the ticks, the ticks will be killed in the first 24-48
hours after attachment. This will usually be prior to engorgement, minimising but not
excluding the risk of transmission of diseases. Once dead, ticks will often drop off
the animal, but any remaining ticks may be removed with a gentle pull.
Fleas from pets often infest the animal's basket, bedding and regular resting areas
such as carpets and soft furnishings which should be treated, in case of massive
infestation and at the beginning of the control measures, with a suitable insecticide
and vacuumed regularly.
For optimal control of flea infestation in multi-pet household, all dogs and cats in the
household should be treated with a suitable insecticide.

Special precautions for use in animals
Animals should be weighed accurately prior to treatment.
Avoid contact with the animal’s eyes. In the case of accidental eye contact,
immediately rinse the eyes with clean water.
It is important to make sure that the product is applied to an area where the animal
cannot lick it off and to make sure that animals do not lick each other following
treatment.
Do not apply the product on wounds or damaged skin.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
Keep pipettes in original packaging until ready to use.
People with a known hypersensitivity to fipronil or excipients (see section 6.1.) should
avoid contact with the veterinary medicinal product.
This product can cause mucous membrane and eye irritation. Therefore, contact
between the product and the mouth or eyes should be avoided.

Revised: August 2018
AN: 00038/2018Page 3 of 7
In the case of accidental eye contact, immediately rinse the eyes with clean water. If
eye irritation persists seek medical advice and show the package leaflet or the label
to the physician.
Avoid contents coming into contact with the skin. If this occurs, wash hands with soap
and water.
Ingestion of the product is harmful. Prevent children getting access to the pipettes
and discard the used pipettes immediately after applying the product.
In case of accidental ingestion of product seek medical advice immediately.
Treated animals should not be handled until the application site is dry, and children
should not be allowed to play with treated animals until the application site is dry. It is
therefore recommended that animals are not treated during the day, but should be
treated during the early evening, and that recently treated animals should not be
allowed to sleep with owners, especially children.
Do not smoke, drink or eat during application. Wash hands after use.
Other precautions
Fipronil may adversely affect aquatic organisms. Dogs should not be allowed to swim
in water courses for 2 days after application.
The product may have adverse effects on painted, varnished or other household
surfaces or furnishings.
Revised: August 2018
AN: 00038/2018Page 4 of 7
None known.
Not applicable.

Revised: August 2018
AN: 00038/2018Page 6 of 7
5.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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