POM-V
Prescription Required
Companion Animal
Alfamed Fipronil 2.5 mg/ml Cutaneous Spray, Solution for Cats and Dogs
Active ingredient: Fipronil
Form
Spray
Species
Cats
Dogs
Manufacturer
Alfamed
VMD MA No.
17902/3015
What it's used for
Treatment of tick infestation (Ixodes ricinus, Rhipicephalus sanguineus) in dogs and cats. Treatment of biting lice infestations in dogs (Trichodectes cani...
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Clinical information
Alfamed Fipronil 2.5 mg/ml Cutaneous Spray, Solution for Cats and Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Treatment of tick infestation (Ixodes ricinus, Rhipicephalus sanguineus) in dogs and
cats.
Treatment of biting lice infestations in dogs (Trichodectes canis) and cats (Felicola
subrostratus).
The veterinary medicinal product can be used as part of a treatment strategy for the
control of Flea Allergy Dermatitis (FAD).
Insecticidal efficacy against new infestations with adult fleas persists for up to 6
weeks in cats and up to 3 months in dogs, depending on environmental challenge.
The veterinary medicinal product has a persistent acaricidal efficacy for up to 4
weeks against ticks, depending on the level of environmental challenge.
cats.
Treatment of biting lice infestations in dogs (Trichodectes canis) and cats (Felicola
subrostratus).
The veterinary medicinal product can be used as part of a treatment strategy for the
control of Flea Allergy Dermatitis (FAD).
Insecticidal efficacy against new infestations with adult fleas persists for up to 6
weeks in cats and up to 3 months in dogs, depending on environmental challenge.
The veterinary medicinal product has a persistent acaricidal efficacy for up to 4
weeks against ticks, depending on the level of environmental challenge.
Route of administration:
Mechanical pump spray for external use only.
The pump delivers 0.5 ml (100 ml bottle) or 1.3 ml (250 and 500 ml bottles) spray per
pump.
Dosage:
100 ml bottle: In order to dampen the coat down to the skin, apply 3 to 6 ml per kg
bodyweight, (7.5 to 15 mg of active ingredient per kg bodyweight), depending on the
length of hair.
This dosage can be achieved with 6 to 12 pump applications per kg bodyweight of
the 100 ml presentation.
250 and 500 ml bottles: In order to dampen the coat down to the skin, apply 3.9 to
5.2 ml per kg bodyweight, (9.8 to 13 mg of active ingredient per kg bodyweight),
depending on the length of hair.
This dosage can be achieved with 3 to 4 pump applications per kg bodyweight of the
250 or 500 ml presentations.
Depending on the coat length,
the 100 ml presentation allows 4 to 8 treatments of a 4 kg cat or up to 3 treatments
of a 10 kg dog,
the 250 ml presentation allows 2 to 3 treatments of a 20 kg dog,
the 500 ml presentation allows 2 to 3 treatments of a 40 kg dog.
Underdosing could result in ineffective use and may favour resistance development.
AN: 01179/2025 & 03351/2025
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Method of administration:
For the 250 and 500 ml bottles, adjust the pump nozzle to spray setting.
Spray the entire body of the animal, and apply from a distance of approximately 10-
20 cm. Apply against the lay of the hair and make sure that the entire coat of the
animal is dampened. Ruffle the coat, especially in long haired animals, so that the
veterinary medicinal product penetrates down to the skin. For treatment of the head
region, and when treating young or nervous pets, application may be carried out by
spraying onto a gloved hand and rubbing the veterinary medicinal product into the
coat. Allow to dry naturally. Do not towel dry.
250 and 500 ml bottles:
100 ml bottle:
Turn the safety ring
on "open".
Properties:
The formulation contains a coating agent. Therefore, spraying builds up a film and
makes the fur glossy.
Treatment schedule:
For optimal control of flea and/or tick infestation, the treatment schedule can be
based on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Puppies and kittens from 2 days of age may be safely treated.
Mechanical pump spray for external use only.
The pump delivers 0.5 ml (100 ml bottle) or 1.3 ml (250 and 500 ml bottles) spray per
pump.
Dosage:
100 ml bottle: In order to dampen the coat down to the skin, apply 3 to 6 ml per kg
bodyweight, (7.5 to 15 mg of active ingredient per kg bodyweight), depending on the
length of hair.
This dosage can be achieved with 6 to 12 pump applications per kg bodyweight of
the 100 ml presentation.
250 and 500 ml bottles: In order to dampen the coat down to the skin, apply 3.9 to
5.2 ml per kg bodyweight, (9.8 to 13 mg of active ingredient per kg bodyweight),
depending on the length of hair.
This dosage can be achieved with 3 to 4 pump applications per kg bodyweight of the
250 or 500 ml presentations.
Depending on the coat length,
the 100 ml presentation allows 4 to 8 treatments of a 4 kg cat or up to 3 treatments
of a 10 kg dog,
the 250 ml presentation allows 2 to 3 treatments of a 20 kg dog,
the 500 ml presentation allows 2 to 3 treatments of a 40 kg dog.
Underdosing could result in ineffective use and may favour resistance development.
AN: 01179/2025 & 03351/2025
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Method of administration:
For the 250 and 500 ml bottles, adjust the pump nozzle to spray setting.
Spray the entire body of the animal, and apply from a distance of approximately 10-
20 cm. Apply against the lay of the hair and make sure that the entire coat of the
animal is dampened. Ruffle the coat, especially in long haired animals, so that the
veterinary medicinal product penetrates down to the skin. For treatment of the head
region, and when treating young or nervous pets, application may be carried out by
spraying onto a gloved hand and rubbing the veterinary medicinal product into the
coat. Allow to dry naturally. Do not towel dry.
250 and 500 ml bottles:
100 ml bottle:
Turn the safety ring
on "open".
Properties:
The formulation contains a coating agent. Therefore, spraying builds up a film and
makes the fur glossy.
Treatment schedule:
For optimal control of flea and/or tick infestation, the treatment schedule can be
based on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Puppies and kittens from 2 days of age may be safely treated.
Do not use on sick (systemic diseases, fever…) or convalescent animals.
Do not use in rabbits, as adverse reactions and even death could occur.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
AN: 01179/2025 & 03351/2025
Do not use in rabbits, as adverse reactions and even death could occur.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
AN: 01179/2025 & 03351/2025
Dogs and cats:
Very rare
(< 1 animal / 10,000
animals treated, including
isolated reports):
Skin disorders (e.g. Erythema, Pruritus, Alopecia)
Hypersalivation
,Vomiting
Neurological disorder (e.g. Hyperesthesia, Central
nervous system depression, Neurological signs)
Respiratory tract disorders
Transient cutaneous reactions.
If licking occurs, a brief period of hypersalivation may be observed due mainly to the
nature of the carrier.
Reversible symptoms.
AN: 01179/2025 & 03351/2025
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Very rare
(< 1 animal / 10,000
animals treated, including
isolated reports):
Skin disorders (e.g. Erythema, Pruritus, Alopecia)
Hypersalivation
,Vomiting
Neurological disorder (e.g. Hyperesthesia, Central
nervous system depression, Neurological signs)
Respiratory tract disorders
Transient cutaneous reactions.
If licking occurs, a brief period of hypersalivation may be observed due mainly to the
nature of the carrier.
Reversible symptoms.
AN: 01179/2025 & 03351/2025
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
When used as part of a strategy for the treatment of flea allergy dermatitis, monthly
applications to the allergic patient and to other cats and dogs in the household are
recommended.
For optimum efficacy, it is not recommended to bathe or shampoo animals in the two
days prior to or following treatment with the veterinary medicinal product. Bathing or
shampooing up to four times in two months has been shown to have no significant
effect on the residual efficacy of the veterinary medicinal product. Monthly treatment
is recommended when more frequent shampooing is carried out.
Treatment of bedding, carpets and soft furnishings with a suitable insecticide will aid
reduction in environmental challenge and maximise the duration of protection against
re-infestation provided by the veterinary medicinal product.
For optimum control of flea problems in a multi-pet household, all dogs and cats in
the household should be treated with a suitable insecticide.
There may be an attachment of single ticks. For this reason transmission of infectious
diseases cannot be completely excluded if conditions are unfavourable.
The veterinary medicinal product is not suitable for direct treatment of the
environment.
Special precautions for safe use in the target species:
Do not exceed the recommended dosage.
Avoid contact with the animal’s eyes.
Do not spray directly onto areas of broken skin.
Allow treated animals to dry in a well ventilated room.
Do not confine animals in an enclosed space or pet carrier until the coat is totally dry.
It is important to make sure that animals do not lick each other following treatment.
Keep treated animals away from fires or other sources of heat, and surfaces likely to
be affected by the alcohol spray, for at least 30 minutes following spraying and until
the fur is totally dry.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product can cause mucous membrane and eye irritation.
Therefore, contact between the veterinary medicinal product and the mouth or eyes
should be avoided.
People with known hypersensitivity to fipronil or excipients should avoid contact with
the veterinary medicinal product. Avoid contents coming into contact with the fingers.
If this occurs, wash hands with soap and water.
AN: 01179/2025 & 03351/2025
After accidental ocular exposure the eye should be rinsed carefully with plain water.
Treated animals should not be handled until the fur is dry, and children should not be
allowed to play with treated animals until the fur is dry. It is therefore recommended
that animals are not treated during the day, but should be treated during the early
evening, and that recently treated animals are not allowed to sleep with owners,
especially children.
Spray animals in the open air or a well ventilated room.
Do not breathe spray. Do not smoke, drink or eat during application.
Wear PVC or nitrile gloves during treatment of animals. It is recommended to wear a
waterproof apron for the protection of clothing. If clothing becomes heavily wetted
with the veterinary medicinal product, it should be removed and washed before re-
use.
Dispose of gloves after use and then wash hands with soap and water.
Wash splashes from skin with soap and water immediately. If irritation occurs, seek
medical advice immediately and show the package leaflet or the label to the
physician.
People with known sensitivity or asthma may be particularly sensitive to the
veterinary medicinal product. Do not use veterinary medicinal product if you have
previously experienced a reaction to it.
Treatment of multiple animals: good ventilation is particularly important where several
animals are to be treated. Treat multiple animals outside, or reduce the build up of
vapour by removing the animals from the treatment room while the alcohol is
evaporating and ensure that the treatment room is well ventilated between individual
treatments. In addition, ensure that the drying room is well ventilated and avoid
housing several recently treated animals within the same air space.
Special precautions for the protection of the environment:
Fipronil may adversely affect aquatic organism. Dogs should not be allowed to swim
in water courses for 2 days after application.
applications to the allergic patient and to other cats and dogs in the household are
recommended.
For optimum efficacy, it is not recommended to bathe or shampoo animals in the two
days prior to or following treatment with the veterinary medicinal product. Bathing or
shampooing up to four times in two months has been shown to have no significant
effect on the residual efficacy of the veterinary medicinal product. Monthly treatment
is recommended when more frequent shampooing is carried out.
Treatment of bedding, carpets and soft furnishings with a suitable insecticide will aid
reduction in environmental challenge and maximise the duration of protection against
re-infestation provided by the veterinary medicinal product.
For optimum control of flea problems in a multi-pet household, all dogs and cats in
the household should be treated with a suitable insecticide.
There may be an attachment of single ticks. For this reason transmission of infectious
diseases cannot be completely excluded if conditions are unfavourable.
The veterinary medicinal product is not suitable for direct treatment of the
environment.
Special precautions for safe use in the target species:
Do not exceed the recommended dosage.
Avoid contact with the animal’s eyes.
Do not spray directly onto areas of broken skin.
Allow treated animals to dry in a well ventilated room.
Do not confine animals in an enclosed space or pet carrier until the coat is totally dry.
It is important to make sure that animals do not lick each other following treatment.
Keep treated animals away from fires or other sources of heat, and surfaces likely to
be affected by the alcohol spray, for at least 30 minutes following spraying and until
the fur is totally dry.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
This veterinary medicinal product can cause mucous membrane and eye irritation.
Therefore, contact between the veterinary medicinal product and the mouth or eyes
should be avoided.
People with known hypersensitivity to fipronil or excipients should avoid contact with
the veterinary medicinal product. Avoid contents coming into contact with the fingers.
If this occurs, wash hands with soap and water.
AN: 01179/2025 & 03351/2025
After accidental ocular exposure the eye should be rinsed carefully with plain water.
Treated animals should not be handled until the fur is dry, and children should not be
allowed to play with treated animals until the fur is dry. It is therefore recommended
that animals are not treated during the day, but should be treated during the early
evening, and that recently treated animals are not allowed to sleep with owners,
especially children.
Spray animals in the open air or a well ventilated room.
Do not breathe spray. Do not smoke, drink or eat during application.
Wear PVC or nitrile gloves during treatment of animals. It is recommended to wear a
waterproof apron for the protection of clothing. If clothing becomes heavily wetted
with the veterinary medicinal product, it should be removed and washed before re-
use.
Dispose of gloves after use and then wash hands with soap and water.
Wash splashes from skin with soap and water immediately. If irritation occurs, seek
medical advice immediately and show the package leaflet or the label to the
physician.
People with known sensitivity or asthma may be particularly sensitive to the
veterinary medicinal product. Do not use veterinary medicinal product if you have
previously experienced a reaction to it.
Treatment of multiple animals: good ventilation is particularly important where several
animals are to be treated. Treat multiple animals outside, or reduce the build up of
vapour by removing the animals from the treatment room while the alcohol is
evaporating and ensure that the treatment room is well ventilated between individual
treatments. In addition, ensure that the drying room is well ventilated and avoid
housing several recently treated animals within the same air space.
Special precautions for the protection of the environment:
Fipronil may adversely affect aquatic organism. Dogs should not be allowed to swim
in water courses for 2 days after application.
None known.
Highly flammable.
Do not store above 25 °C.
Protect from direct sunlight.
Do not store above 25 °C.
Protect from direct sunlight.
Not applicable.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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