POM-V
Prescription Required
Companion Animal
Alfamed 2.5 mg/ml Cutaneous Spray, Solution for Cats and Dogs
Active ingredient: Fipronil
Form
Spray
Species
Cats
Dogs
Manufacturer
Alfamed
VMD MA No.
17902/5020
What it's used for
Treatment of flea infestation (Ctenocephalides spp.) in dogs and cats. Treatment of tick infestation (Ixodes ricinus, Rhipicephalus sanguineus) in dogs and...
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Prescription required
Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.
Clinical information
Alfamed 2.5 mg/ml Cutaneous Spray, Solution for Cats and Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.
Treatment of flea infestation (Ctenocephalides spp.) in dogs and cats.
Treatment of tick infestation (Ixodes ricinus, Rhipicephalus sanguineus) in dogs and
cats.
Treatment of biting lice infestations in dogs (Trichodectes canis) and cats (Felicola
subrostratus).
The product can be used as part of a treatment strategy for the control of Flea Allergy
Dermatitis (FAD).
Insecticidal efficacy against new infestations with adult fleas persists for up to 6
weeks in cats and up to 3 months in dogs, depending on environmental challenge.
The product has a persistent acaricidal efficacy for up to 4 weeks against ticks,
depending on the level of environmental challenge.
Treatment of tick infestation (Ixodes ricinus, Rhipicephalus sanguineus) in dogs and
cats.
Treatment of biting lice infestations in dogs (Trichodectes canis) and cats (Felicola
subrostratus).
The product can be used as part of a treatment strategy for the control of Flea Allergy
Dermatitis (FAD).
Insecticidal efficacy against new infestations with adult fleas persists for up to 6
weeks in cats and up to 3 months in dogs, depending on environmental challenge.
The product has a persistent acaricidal efficacy for up to 4 weeks against ticks,
depending on the level of environmental challenge.
Route of administration:
Mechanical pump spray for external use only.
The pump delivers 0.5 ml (100 ml bottle) or 1.3 ml (250 and 500 ml bottles) spray per
pump.
Dosage:
100 ml bottle: In order to dampen the coat down to the skin, apply 3 to 6 ml per kg
bodyweight, (7.5 to 15 mg of active ingredient per kg bodyweight), depending on the
length of hair.
This dosage can be achieved with 6 to 12 pump applications per kg bodyweight of
the 100 ml presentation.
250 and 500 ml bottles: In order to dampen the coat down to the skin, apply 3.9 to
5.2 ml per kg bodyweight, (9.8 to 13 mg of active ingredient per kg bodyweight),
depending on the length of hair.
This dosage can be achieved with 3 to 4 pump applications per kg bodyweight of the
250 or 500 ml presentations.
Depending on the coat length,
the 100 ml presentation allows 4 to 8 treatments of a 4 kg cat or up to 3 treatments
of a 10 kg dog,
the 250 ml presentation allows 2 to 3 treatments of a 20 kg dog,
the 500 ml presentation allows 2 to 3 treatments of a 40 kg dog.
Underdosing could result in ineffective use and may favour resistance development.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Method of administration:
For the 250 and 500 ml bottles, adjust the pump nozzle to spray setting.
Spray the entire body of the animal, and apply from a distance of approximately 10-
20 cm. Apply against the lay of the hair and make sure that the entire coat of the
animal is dampened. Ruffle the coat, especially in long haired animals, so that the
product penetrates down to the skin. For treatment of the head region, and when
treating young or nervous pets, application may be carried out by spraying onto a
gloved hand and rubbing the product into the coat. Allow to dry naturally. Do not
towel dry.
250 and 500 ml bottles:
Amended Pages: January 2026
AN: 03031/2025
100 ml bottle:
Turn the safety ring
on "open".
Properties:
The formulation contains a coating agent. Therefore, spraying builds up a film and
makes the fur glossy.
Treatment schedule:
For optimal control of flea and/or tick infestation, the treatment schedule can be
based on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Puppies and kittens from 2 days of age may be safely treated.
Mechanical pump spray for external use only.
The pump delivers 0.5 ml (100 ml bottle) or 1.3 ml (250 and 500 ml bottles) spray per
pump.
Dosage:
100 ml bottle: In order to dampen the coat down to the skin, apply 3 to 6 ml per kg
bodyweight, (7.5 to 15 mg of active ingredient per kg bodyweight), depending on the
length of hair.
This dosage can be achieved with 6 to 12 pump applications per kg bodyweight of
the 100 ml presentation.
250 and 500 ml bottles: In order to dampen the coat down to the skin, apply 3.9 to
5.2 ml per kg bodyweight, (9.8 to 13 mg of active ingredient per kg bodyweight),
depending on the length of hair.
This dosage can be achieved with 3 to 4 pump applications per kg bodyweight of the
250 or 500 ml presentations.
Depending on the coat length,
the 100 ml presentation allows 4 to 8 treatments of a 4 kg cat or up to 3 treatments
of a 10 kg dog,
the 250 ml presentation allows 2 to 3 treatments of a 20 kg dog,
the 500 ml presentation allows 2 to 3 treatments of a 40 kg dog.
Underdosing could result in ineffective use and may favour resistance development.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Method of administration:
For the 250 and 500 ml bottles, adjust the pump nozzle to spray setting.
Spray the entire body of the animal, and apply from a distance of approximately 10-
20 cm. Apply against the lay of the hair and make sure that the entire coat of the
animal is dampened. Ruffle the coat, especially in long haired animals, so that the
product penetrates down to the skin. For treatment of the head region, and when
treating young or nervous pets, application may be carried out by spraying onto a
gloved hand and rubbing the product into the coat. Allow to dry naturally. Do not
towel dry.
250 and 500 ml bottles:
Amended Pages: January 2026
AN: 03031/2025
100 ml bottle:
Turn the safety ring
on "open".
Properties:
The formulation contains a coating agent. Therefore, spraying builds up a film and
makes the fur glossy.
Treatment schedule:
For optimal control of flea and/or tick infestation, the treatment schedule can be
based on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Puppies and kittens from 2 days of age may be safely treated.
Do not use on sick (systemic diseases, fever…) or convalescent animals.
Do not use in rabbits, as adverse reactions and even death could occur.
Amended Pages: January 2026
AN: 03031/2025
Do not use in cases of hypersensitivity to the active substance or to any of
excipients.
Do not use in rabbits, as adverse reactions and even death could occur.
Amended Pages: January 2026
AN: 03031/2025
Do not use in cases of hypersensitivity to the active substance or to any of
excipients.
If licking occurs, a brief period of hypersalivation may be observed due mainly to the
nature of the carrier.
Among the extremely rare suspected adverse reactions, transient cutaneous
reactions erythema such as pruritus or alopecia have been reported after use.
Exceptionally, hypersalivation, reversible neurological signs (hyperaesthesia,
depression, nervous signs), vomiting or respiratory signs have been observed after
use.
nature of the carrier.
Among the extremely rare suspected adverse reactions, transient cutaneous
reactions erythema such as pruritus or alopecia have been reported after use.
Exceptionally, hypersalivation, reversible neurological signs (hyperaesthesia,
depression, nervous signs), vomiting or respiratory signs have been observed after
use.
When used as part of a strategy for the treatment of flea allergy dermatitis, monthly
applications to the allergic patient and to other cats and dogs in the household are
recommended.
For optimum efficacy, it is not recommended to bathe or shampoo animals in the two
days prior to or following treatment with the product. Bathing or shampooing up to
four times in two months has been shown to have no significant effect on the residual
efficacy of the product. Monthly treatment is recommended when more frequent
shampooing is carried out.
Treatment of bedding, carpets and soft furnishings with a suitable insecticide will aid
reduction in environmental challenge and maximise the duration of protection against
re-infestation provided by the product.
For optimum control of flea problems in a multi-pet household, all dogs and cats in
the household should be treated with a suitable insecticide.
There may be an attachment of single ticks. For this reason transmission of infectious
diseases cannot be completely excluded if conditions are unfavourable.
The product is not suitable for direct treatment of the environment.
Special precautions for use in animals
Do not exceed the recommended dosage.
Avoid contact with the animal’s eyes.
Do not spray directly onto areas of broken skin.
Allow treated animals to dry in a well ventilated room.
Do not confine animals in an enclosed space or pet carrier until the coat is totally dry.
It is important to make sure that animals do not lick each other following treatment.
Keep treated animals away from fires or other sources of heat, and surfaces likely to
be affected by the alcohol spray, for at least 30 minutes following spraying and until
the fur is totally dry.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product can cause mucous membrane and eye irritation. Therefore, contact
between the product and the mouth or eyes should be avoided.
People with known hypersensitivity to fipronil or excipients should avoid contact with
the veterinary medicinal product. Avoid contents coming into contact with the fingers.
If this occurs, wash hands with soap and water.
After accidental ocular exposure the eye should be rinsed carefully with plain water.
Amended Pages: January 2026
AN: 03031/2025
Treated animals should not be handled until the fur is dry, and children should not be
allowed to play with treated animals until the fur is dry. It is therefore recommended
that animals are not treated during the day, but should be treated during the early
evening, and that recently treated animals are not allowed to sleep with owners,
especially children.
Spray animals in the open air or a well ventilated room.
Do not breathe spray. Do not smoke, drink or eat during application.
Wear PVC or nitrile gloves during treatment of animals. It is recommended to wear a
waterproof apron for the protection of clothing. If clothing becomes heavily wetted
with the product, it should be removed and washed before re-use.
Dispose of gloves after use and then wash hands with soap and water.
Wash splashes from skin with soap and water immediately. If irritation occurs, seek
medical advice. People with known sensitivity or asthma may be particularly
sensitive to the product. Do not use product if you have previously experienced a
reaction to it.
Treatment of multiple animals: Good ventilation is particularly important where
several animals are to be treated. Treat multiple animals outside, or reduce the build
up of vapour by removing the animals from the treatment room while the alcohol is
evaporating and ensure that the treatment room is well ventilated between individual
treatments. In addition, ensure that the drying room is well ventilated and avoid
housing several recently treated animals within the same air space.
Other precautions
Fipronil may adversely affect aquatic organism. Dogs should not be allowed to swim
in water courses for 2 days after application.
applications to the allergic patient and to other cats and dogs in the household are
recommended.
For optimum efficacy, it is not recommended to bathe or shampoo animals in the two
days prior to or following treatment with the product. Bathing or shampooing up to
four times in two months has been shown to have no significant effect on the residual
efficacy of the product. Monthly treatment is recommended when more frequent
shampooing is carried out.
Treatment of bedding, carpets and soft furnishings with a suitable insecticide will aid
reduction in environmental challenge and maximise the duration of protection against
re-infestation provided by the product.
For optimum control of flea problems in a multi-pet household, all dogs and cats in
the household should be treated with a suitable insecticide.
There may be an attachment of single ticks. For this reason transmission of infectious
diseases cannot be completely excluded if conditions are unfavourable.
The product is not suitable for direct treatment of the environment.
Special precautions for use in animals
Do not exceed the recommended dosage.
Avoid contact with the animal’s eyes.
Do not spray directly onto areas of broken skin.
Allow treated animals to dry in a well ventilated room.
Do not confine animals in an enclosed space or pet carrier until the coat is totally dry.
It is important to make sure that animals do not lick each other following treatment.
Keep treated animals away from fires or other sources of heat, and surfaces likely to
be affected by the alcohol spray, for at least 30 minutes following spraying and until
the fur is totally dry.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
This product can cause mucous membrane and eye irritation. Therefore, contact
between the product and the mouth or eyes should be avoided.
People with known hypersensitivity to fipronil or excipients should avoid contact with
the veterinary medicinal product. Avoid contents coming into contact with the fingers.
If this occurs, wash hands with soap and water.
After accidental ocular exposure the eye should be rinsed carefully with plain water.
Amended Pages: January 2026
AN: 03031/2025
Treated animals should not be handled until the fur is dry, and children should not be
allowed to play with treated animals until the fur is dry. It is therefore recommended
that animals are not treated during the day, but should be treated during the early
evening, and that recently treated animals are not allowed to sleep with owners,
especially children.
Spray animals in the open air or a well ventilated room.
Do not breathe spray. Do not smoke, drink or eat during application.
Wear PVC or nitrile gloves during treatment of animals. It is recommended to wear a
waterproof apron for the protection of clothing. If clothing becomes heavily wetted
with the product, it should be removed and washed before re-use.
Dispose of gloves after use and then wash hands with soap and water.
Wash splashes from skin with soap and water immediately. If irritation occurs, seek
medical advice. People with known sensitivity or asthma may be particularly
sensitive to the product. Do not use product if you have previously experienced a
reaction to it.
Treatment of multiple animals: Good ventilation is particularly important where
several animals are to be treated. Treat multiple animals outside, or reduce the build
up of vapour by removing the animals from the treatment room while the alcohol is
evaporating and ensure that the treatment room is well ventilated between individual
treatments. In addition, ensure that the drying room is well ventilated and avoid
housing several recently treated animals within the same air space.
Other precautions
Fipronil may adversely affect aquatic organism. Dogs should not be allowed to swim
in water courses for 2 days after application.
None known.
Amended Pages: January 2026
AN: 03031/2025
Amended Pages: January 2026
AN: 03031/2025
Highly flammable.
Do not store above 25°C.
Protect from direct sunlight.
Do not store above 25°C.
Protect from direct sunlight.
depending on the length of hair.
This dosage can be achieved with 3 to 4 pump applications per kg bodyweight of the
250 or 500 ml presentations.
Depending on the coat length,
the 100 ml presentation allows 4 to 8 treatments of a 4 kg cat or up to 3 treatments
of a 10 kg dog,
the 250 ml presentation allows 2 to 3 treatments of a 20 kg dog,
the 500 ml presentation allows 2 to 3 treatments of a 40 kg dog.
Underdosing could result in ineffective use and may favour resistance development.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Method of administration:
For the 250 and 500 ml bottles, adjust the pump nozzle to spray setting.
Spray the entire body of the animal, and apply from a distance of approximately 10-
20 cm. Apply against the lay of the hair and make sure that the entire coat of the
animal is dampened. Ruffle the coat, especially in long haired animals, so that the
product penetrates down to the skin. For treatment of the head region, and when
treating young or nervous pets, application may be carried out by spraying onto a
gloved hand and rubbing the product into the coat. Allow to dry naturally. Do not
towel dry.
250 and 500 ml bottles:
Amended Pages: January 2026
AN: 03031/2025
100 ml bottle:
Turn the safety ring
on "open".
Properties:
The formulation contains a coating agent. Therefore, spraying builds up a film and
makes the fur glossy.
Treatment schedule:
For optimal control of flea and/or tick infestation, the treatment schedule can be
based on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Puppies and kittens from 2 days of age may be safely treated.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The risk of adverse effects may increase in cases of overdose.
Start an appropriate symptomatic treatment in case of overdosing.
4.11 Withdrawal period
Not applicable.
5.
This dosage can be achieved with 3 to 4 pump applications per kg bodyweight of the
250 or 500 ml presentations.
Depending on the coat length,
the 100 ml presentation allows 4 to 8 treatments of a 4 kg cat or up to 3 treatments
of a 10 kg dog,
the 250 ml presentation allows 2 to 3 treatments of a 20 kg dog,
the 500 ml presentation allows 2 to 3 treatments of a 40 kg dog.
Underdosing could result in ineffective use and may favour resistance development.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Method of administration:
For the 250 and 500 ml bottles, adjust the pump nozzle to spray setting.
Spray the entire body of the animal, and apply from a distance of approximately 10-
20 cm. Apply against the lay of the hair and make sure that the entire coat of the
animal is dampened. Ruffle the coat, especially in long haired animals, so that the
product penetrates down to the skin. For treatment of the head region, and when
treating young or nervous pets, application may be carried out by spraying onto a
gloved hand and rubbing the product into the coat. Allow to dry naturally. Do not
towel dry.
250 and 500 ml bottles:
Amended Pages: January 2026
AN: 03031/2025
100 ml bottle:
Turn the safety ring
on "open".
Properties:
The formulation contains a coating agent. Therefore, spraying builds up a film and
makes the fur glossy.
Treatment schedule:
For optimal control of flea and/or tick infestation, the treatment schedule can be
based on the local epidemiological situation.
In the absence of safety studies, the minimum treatment interval is 4 weeks.
Puppies and kittens from 2 days of age may be safely treated.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
The risk of adverse effects may increase in cases of overdose.
Start an appropriate symptomatic treatment in case of overdosing.
4.11 Withdrawal period
Not applicable.
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
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