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POM-V Prescription Required Companion Animal

Urixine 40 mg/ml Syrup for Dogs

Active ingredient: Phenylpropanolamine

Form

Liquid

Species

Dogs

Manufacturer

Laboratorios Karizoo S.A

VMD MA No.

31223/5002

What it's used for

Efficacy has been only demonstrated with ovariohysterectomised bitches.

Full indications, dosage and side effects ↓
View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Phenylpropanolamine

  1. 1

    Ask your vet for a written prescription

    They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.

  2. 2

    Fill it at a registered online retailer

    The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

Urixine 40 mg/ml Syrup for Dogs — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Efficacy has been only demonstrated with ovariohysterectomised bitches.
The recommended dose is 1 mg of phenylpropanolamine/kg b.w. 3 times a day, with
food (equivalent to 0.1 ml of veterinary medicinal product for every 5 kg b.w. 3 times
a day).
Absorption of the veterinary medicinal product is increased when administered to
dogs in an empty stomach.
To ensure a correct dosage, body weight should be determined as accurately as
possible.
Do not administer to patients treated with non-selective monoamine oxidase
inhibitors.
Do not use in cases of hypersensitivity to the active substance or to any of the
excipients.
Dogs:
Rare (more than 1 but less
than 10 animals in 10,000
animals treated)
Loose stools
, liquid diarrhoea
Emesis, lethargy
Very rare
(<1 animal / 10,000 animals
treated, including isolated
reports):
Decreased appetite
, collapse
Dizziness, ataxia
Increased blood pressure, increased heart rate,
Arrhythmia
Hyperactivity (including restlessness), aggression
Polyuria, polydipsia
Hypersensitivity reaction
Seizure
Treatment can be continued depending on the severity of the undesirable effect
observed.
Sympathomimetics can produce a wide variety of effects, many of which mimic the
reactions of excessive stimulation of the sympathetic nervous system which can
induce proteinuria.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
The use of the veterinary medicinal product is not appropriate for the treatment of
behavioural causes of inappropriate urination.
In bitches less than 1 year old the possibility of anatomical disorders contributing to
incontinence should be considered prior to treatment.

Special precautions for safe use in the target species:
Phenylpropanolamine, a sympathomimetic drug, may affect the cardiovascular
system, especially blood pressure and heart rate, and should be used with caution in
animals with cardiovascular diseases.
Care should be exercised in treating animals with severe renal or hepatic
insufficiency, diabetes mellitus, hyperadrenocorticism, glaucoma, hyperthyroidism or
other metabolic disorders.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Phenylpropanolamine Hydrochloride is toxic when ingested in higher doses.
Adverse effects may include dizziness, headache, nausea, insomnia or restlessness,
and increased blood pressure. Higher doses may be fatal, especially in children.
Avoid oral ingestion including hand-to-mouth contact.
To avoid accidental ingestion, the veterinary medicinal product should be used and
stored out of sight and reach of children. Always close the cap tightly after use to
ensure the child-resistant closure works correctly. Do not leave a filled syringe
unattended.
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician. Wash hands after handling the
veterinary medicinal product.
This veterinary medicinal product may cause skin and eye irritation. Avoid skin and
eye contact.
In case of accidental skin contact, wash the contaminated area with soap and water.
In case of accidental eye contact, rinse the eye thoroughly with clean water and
consult a physician if irritation persists.
People with known hypersensitivity (allergy) to phenylpropanolamine hydrochloride
should avoid contact with the veterinary medicinal product. Wear gloves. If allergic
symptoms develop, such as a skin rash, swelling of the face, lips or eyes or difficulty
in breathing, you should seek medical attention immediately and show the package
leaflet or label to the physician.
Special precautions for the protection of the environment:
Not applicable.
Care should be exercised in administering the veterinary medicinal product with
other sympathomimetic drugs, anticholinergic drugs, tricyclic antidepressants or
specific type B monoamine oxidase inhibitors.
This veterinary medicinal product does not require any special storage conditions.
Not applicable

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.

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