Atipam 5.0 mg/ml, Solution for Injection for Cats and Dogs
Active ingredient: Atipamezole Hydrochloride
Form
Injection
Species
Manufacturer
Eurovet Animal Health B.V.
VMD MA No.
16849/4011
What it's used for
Atipamezole is indicated for the reversal of the sedative & analgesic effects of medetomidine or dexmedetomidine in dogs and cats. It also reverses all oth...
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Atipam 5.0 mg/ml, Solution for Injection for Cats and Dogs — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
medetomidine or dexmedetomidine in dogs and cats. It also reverses all other effects
of medetomidine or dexmedetomidine, such as cardiovascular and respiratory
effects.
volumes. Atipamezole is generally administered 15 - 60 minutes after the
medetomidine or dexmedetomidine injection.
Dogs: The atipamezole hydrochloride dose (in µg) is five times that of the previous
medetomidine hydrochloride dose or ten times that of the dexmedetomidine
hydrochloride dose. Due to the 5-fold higher concentration of the active ingredient
(atipamezole hydrochloride) in this veterinary medicinal product compared to that of
preparations containing 1 mg medetomidine hydrochloride per ml and the 10-fold
higher concentration compared to that of preparations containing 0.5 mg
dexmedetomidine hydrochloride, an equal volume of each preparation is required.
Dosage example dogs:
Medetomidine 1.0 mg/ml solution for
injection dosage
Atipam 5.0 mg/ml solution for
injection dosage
0,04 ml/kg body weight (bw),
i.e. 40 μg/kg bw
0,04 ml/kg body weight (bw),
i.e. 200 μg/kg bw
Dexmedetomidine 0.5 mg/ml solution
for injection dosage
Atipam 5.0 mg/ml solution for
injection dosage
0,04 ml/kg body weight (bw),
i.e. 20 μg/kg bw
0,04 ml/kg body weight (bw),
i.e. 200 μg/kg bw
AN: 00347/2024 & 00349/2024
Cats: The atipamezole hydrochloride dose (in µg) is two-and-a-half times that of the
previous medetomidine hydrochloride dose or five times that of the dexmedetomidine
hydrochloride dose. Due to the 5-fold higher concentration of the active ingredient
(atipamezole hydrochloride) in this veterinary medicinal product compared to that of
preparations containing 1 mg medetomidine hydrochloride per ml and the 10-fold
higher concentration compared to that of preparations containing 0.5 mg
dexmedetomidine hydrochloride, half the volume of the veterinary medicinal product
to that of the previously administered medetomidine or dexmedetomidine should be
given.
Dosage example cats:
Medetomidine 1.0 mg/ml solution for
injection dosage
Atipam 5.0 mg/ml solution for
injection dosage
0,08 ml/kg body weight (bw),
i.e. 80 μg/kg bw
0,04 ml/kg body weight (bw),
i.e. 200 μg/kg bw
Dexmedetomidine 0.5 mg/ml solution
for injection dosage
Atipam 5.0 mg/ml solution for
injection dosage
0,08 ml/kg body weight (bw),
i.e. 40 μg/kg bw
0,04 ml/kg body weight (bw),,
i.e. 200 μg/kg bw
The recovery time is shortened to approximately 5 minutes. The animals become
mobile after approximately 10 minutes after administration of the veterinary medicinal
product.
Do not use in animals suffering from liver- or renal diseases.
See also section 3.7.
AN: 00347/2024 & 00349/2024
Rare
(1 to 10 animals / 10,000 animals treated):
Hyperactivity, Vocalisation
a
, Involuntary
urination, Involuntary defecation
Tachycardia
Increased salivation, Vomiting
Muscle tremor
Increased respiratory rate
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Hypotension
b
Sedation
c
, Recovery prolonged
d
Hypothermia
e
a
Atypical.
AN: 00347/2024 & 00349/2024
b
Transient effect that has been observed during the first 10 minutes post-injection of
atipamezole hydrochloride.
c
Recurrence.
d
The recovery time may not be shortened after administration of atipamezole.
e
In cats, when using low doses to partially reverse the effects of medetomidine or
dexmedetomidine. Should be guarded against, even when aroused from sedation.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or its local representative or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
drink is offered.
Special precautions for safe use in the target species:
After administration of the veterinary medicinal product, the animals should be
allowed to rest in a quiet place. During recovery time animals should not be left
unattended.
Due to different dosing recommendations caution should be taken if using the
veterinary medicinal product off-label in animals other than the target species.
If sedatives other than (dex)medetomidine are given, it must be kept in mind that the
effects of those other agents may persist after reversal of (dex)medetomidine.
Atipamezole does not reverse the effect of ketamine, which may cause seizures in
dogs and elicit cramps in cats when used alone. Do not administer atipamezole
within 30 – 40 minutes of prior administration of ketamine.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Due to the potent pharmacological activity of atipamezole, skin-, eye- and mucous
membrane- contact with this veterinary medicinal product should be avoided. In case
of accidental contact of the veterinary medicinal product with skin or eyes rinse
abundantly with fresh water. Seek medical attention if irritation persists. Remove
contaminated clothes that are in direct contact with the skin.
Care should be taken to avoid accidental ingestion or self-injection. In case of
accidental
ingestion or self-injection, seek medical advice immediately and show the package
leaflet to
the physician.
Special precautions for the protection of the environment:
Not applicable.
medicinal products as diazepam, acepromazine or opiates is not recommended.
Each ml contains:
Active substance:
Atipamezole hydrochloride 5.0 mg
(equivalent to 4.27 mg atipamezole base)
Excipients:
Qualitative composition of excipients
and other constituents
Quantitative composition if that
information is essential for proper
administration of the veterinary
medicinal product
Methyl parahydroxybenzoate (E218)1.0 mgSodium chlorideSodium hydrochloride (for pH adjustment)Hydrochloric acid (for pH adjustment)Water for injections
Clear and colourless aqueous solution.
3. CLINICAL INFORMATION
3.1 Target species
Dogs and cats.
3.2 Indications for use for each target species
Atipamezole hydrochloride is a selective α2-antagonist
the sedative effects of medetomidine and dexmedetomidine in cats and dogs.
3.3 Contraindications
Do not use in breeding animals.
Do not use in animals suffering from liver- or renal diseases.
See also section 3.7.
AN: 00347/2024 & 00349/2024
3.4 Special warnings
Make sure the animal has regained a normal swallowing reflex before any food or
drink is offered.
3.5 Special precautions for use
Special precautions for safe use in the target species:
After administration of the veterinary medicinal product, the animals should be
allowed to rest in a quiet place. During recovery time animals should not be left
unattended.
Due to different dosing recommendations caution should be taken if using the
veterinary medicinal product off-label in animals other than the target species.
If sedatives other than (dex)medetomidine are given, it must be kept in mind that the
effects of those other agents may persist after reversal of (dex)medetomidine.
Atipamezole does not reverse the effect of ketamine, which may cause seizures in
dogs and elicit cramps in cats when used alone. Do not administer atipamezole
within 30 – 40 minutes of prior administration of ketamine.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Due to the potent
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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