Revertor 5 mg/ml Solution for Injection for Dogs and Cats
Active ingredient: Atipamezole Hydrochloride
Form
Injection
Species
Manufacturer
CP Pharma Handelsgesellschaft mbH
VMD MA No.
20916/4003
What it's used for
Atipamezole is indicated for the reversal of the sedative & analgesic effects of medetomidine or dexmedetomidine in dogs and cats. It also reverses all oth...
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Revertor 5 mg/ml Solution for Injection for Dogs and Cats — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
medetomidine or dexmedetomidine in dogs and cats. It also reverses all other effects
of medetomidine or dexmedetomidine, such as cardiovascular and respiratory
effects.
Dogs: The optimal dose of atipamezole in micrograms per kilogram is five times that
of the previous medetomidine dose or 10 times the dexmedetomidine dose.
Antisedan dose in millilitres is the same as that of medetomidine 1 mg/ml or
dexmedetomidine 0.5 mg/ml dose. Antisedan dose in millilitres is one fifth (1/5) of the
Revised: September 2019
AN: 01288/2018
dose volume of dexmedetomidine 0.1 mg/ml. When medetomidine or
dexmedetomidine have been used with or without butorphanol as a premedicant to
thiopentone-halothane anaesthesia in dogs, or as premedicant to propofol
anaesthesia in dogs, the product may be administered in the post-operative phase to
reverse the effects of medetomidine or dexmedetomidine and hasten recovery.
Cats: The optimal dose of atipamezole in micrograms per kg is two-and-a-half times
that of the previous medetomidine dose or five times the dexmedetomidine dose.
The Antisedan dose in millilitres is half of that of medetomidine 1 mg/ml or
dexmedetomidine 0.5 mg/ml dose and one tenth (1/10) of dexmedetomidine 0.1
mg/ml dose.
Example dosages:
Dogs:
Medetomidine
dosage
Dexmedetomidine
0.5 mg/ml dosage
Dexmedetomidine
0.1 mg/ml dosage
Antisedan dosage
40 mcg/kg20 mcg/kg20 mcg /kg200 mcg/kg
= 0.4 ml/10 kg= 0.4 ml/10 kg= 2.0 ml/10 kg= 0.4 ml/10 kg
Cats:
Medetomidine
dosage
Dexmedetomidine
0.5 mg/ml dosage
Dexmedetomidine
0.1 mg/ml dosage
Antisedan dosage80 mcg/kg40 mcg/kg 40 mcg/kg200 mcg/kg= 0.4 ml/5 kg
= 0.4 ml/5 kg = 1.2 ml/3 kg*= 0.2 ml/5kg
0.12 ml/3kg
* For cats weighing over 3 kg, dexmedetomidine 0.5 mg/ml is recommended.
The dose in micrograms per kg should not exceed four times that of the previously
administered medetomidine or eight times that of dexmedetomidine.
When cats have been anaesthetised with medetomidine or dexmedetomidine, with
or without butorphanol, and ketamine the product may be administered to reverse
the effects of medetomidine or dexmedetomidine and so speed recovery from
anaesthesia. The veterinary medicinal product dosage in this instance is the same
as that used for recovery after single administration of medetomidine or
dexmedetomidine; however, the veterinary medicinal product should not be
administered prior to 30 to 40 minutes following ketamine administration.
excipients.
In dogs a transient hypotensive effect has been observed during the first ten minutes
post-injection. Vomiting, panting, defaecation and excessive salivation and muscle
tremors (possibly shivering) have been reported but these effects appear to be very
rare. Transient hyperactivity and tachycardia may be observed in a few individuals.
In cats, when using low doses to partially reverse the effects of medetomidine or
dexmedetomidine, the possibility of hypothermia (even when aroused from sedation)
should be guarded against.
The frequency of adverse reactions is defined using the following convention:
- very common (more than 1 in 10 animals displaying adverse reactions during the
course of one treatment)
- common (more than 1 but less than 10 animals in 100 animals)
- uncommon (more than 1 but less than 10 animals in 1,000 animals)
- rare (more than 1 but less than 10 animals in 10,000 animals)
- very rare (less than 1 animal in 10,000 animals, including isolated reports)
allowed to rest in a maximally quiet place.
When any combination of butorphanol or medetomidine or dexmedetomidine and
ketamine have been used, atipamezole should not be used to reverse the effect in
dogs.
Special precautions for use in animals
With the exception of those drugs mentioned within the SPC, the concurrent use of
drugs affecting the CNS is not recommended.
Revised: September 2019
AN: 01288/2018
Antisedan should not be administered within 30-40 minutes of the administration of
ketamine in cats. If the effect of the alpha-2 agonist is eliminated earlier, the residual
effect of ketamine may cause convulsions.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Due to the potent pharmacological activity of atipamezole, contact with skin or
mucosal membranes should be avoided and impervious gloves should be worn
during administration. Care should be taken to avoid accidental self-injection. If
accidental self-injection occurs, seek immediate medical attention showing a copy of
the package leaflet. Do not drive. The patient should not be left unattended. In case
of accidental spillage, wash the affected area immediately with clean running water.
Seek medical attention if irritation persists. In case of accidental ingestion, seek
medical advice immediately.
of those drugs affecting the CNS is not recommended apart from those in the SPC
Protect from light.
Following withdrawal of the first dose, use the product within 3 months. Discard any
unused material.
Revised: September 2019
AN: 01288/2018
5.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Related Conditions
Other Products Containing Atipamezole Hydrochloride
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
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POM-VAlfasan Nederland B.V.
Dormostop 5 mg/ml Solution for Injection for Dogs and Cats
POM-VAlfasan Nederland B.V.
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