Topimec 5 mg/ml Pour-on Solution

Do not treat cattle when hair or hide is wet. Do not treat cattle if rain is expected, as
rain within two hours of treatment may reduce efficacy. However, the efficacy of the
product against established infections of O. ostertagi or D. viviparus is not adversely
affected if the hide is wet or if rain falls shortly after treatment.
Do not apply to areas of skin that may have mange scabs or other lesions or to areas
contaminated with mud or manure.
Care should be taken to avoid the following practices because they increase the risk
of development of resistance and could ultimately result in ineffective therapy:
- Too frequent and repeated use of anthelmintics from the same class, over an
extended period of time.
- Underdosing, which may be due to underestimation of body weight,
misadministration of the product, or lack of calibration of the dosing device.

Amended pages: November 2025
AN: 01686/2025
Suspected clinical cases of resistance to anthelmintics should be further investigated
using appropriate tests (e.g. Faecal Egg Count Reduction Test). Where the results of
the test(s) strongly suggest resistance to a particular anthelmintic, an anthelmintic
belonging to another pharmacological class and having a different mode of action
should be used.
Resistance to ivermectin has been reported in Cooperia spp. and in
ostertagi in cattle. Resistance has also been reported in in
cattle outside the EU. Therefore, the use of this product should be based on local
(region, farm) epidemiological information about susceptibility of this helminth species
and recommendations on how to limit further selection for resistance to anthelmintics.

Special precautions for use in animals
Ivermectins may not be well tolerated in all non-target species. Cases of intolerance
with fatal outcome are reported in dogs, especially Collies, Old English Sheepdogs
and related breeds or crosses, and also in turtles/tortoises. To avoid secondary
reactions due to the death of larvae in the oesophagus or in the spine, it
is recommended to administer the product at the end of the period of warble fly
activity and before the larvae reach their resting site. As Ivermectin is extremely
dangerous to fish and aquatic life, treated animals should not have direct access to
surface water and ditches during treatment.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
The product may be irritating to human skin and eyes and the user should be careful
not to apply it to himself or other persons. Operators should wear rubber gloves and
boots with a waterproof coat when applying the product. Protective clothing should
be washed after use. Use only in well-ventilated areas or outdoors.
HIGHLY FLAMMABLE.
Keep away from heat, spark, open flame or other source of ignition. Do not eat, drink
or smoke whilst handling the product.
As absorption through skin can occur, in the event of accidental skin contact the
affected area should be washed immediately with soap and water. If irritation
persists, seek medical advice and show the package label to the doctor.
If accidental eye exposure occurs, flush the eyes immediately with water and seek
medical attention. Wash hands after use.
For external use only.
Other precautions
The influence of extreme climatic conditions on persistent activity of the product is
unknown. The product is very toxic to aquatic organisms and dung insects.
Treated cattle should not have direct access to ponds, streams or ditches for 14 days
after treatment. Long term effects on dung insects caused by continuous or repeated
use cannot be excluded therefore repeat treatments on a pasture with in a season
should only be given on the advice of the veterinarian.

Amended pages: November 2025
AN: 01686/2025