Solantel 200mg/ml Pour-On Solution for Cattle
Active ingredient: Closantel
Form
Spot-on
Species
Manufacturer
Norbrook Laboratories Limited
VMD MA No.
02000/4442
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Solantel 200mg/ml Pour-On Solution for Cattle — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
The veterinary medicinal product should be administered topically at a dosage
rate of 20 mg closantel per kg bodyweight (1 ml per 10 kg).
The formulation should be applied along the midline of the back in a narrow strip
between the withers and the tail head.
Assess bodyweight carefully prior to administration.
The timing for treatment should be based on epidemiological factors and should
be customised for each individual farm. The veterinary medicinal product should
not be repeatedly applied to cattle within 10 weeks of first administration.
AN: 04362/2024 & 04363/2024
Handy Dosing Guide
Animals should be weighed and grouped
according to bodyweight to avoid under
or over-dosing
Number of Full Doses per Pack
BodyweightDose Volume
1 Litre2.5 Litre5 Litre100 kg*10 ml100250500150 kg15 ml66166333200 kg20 ml50125250250 kg25 ml40100200300 kg30 ml3383166350 kg35 ml2871142400 kg40 ml2562125450 kg45 ml2255111500 kg50 ml2050100550 kg55 ml184590600 kg60 ml164183
* Dose rate 1 ml per 10 kg bodyweight
excipients.
Do not apply to areas of skin which have mange, scabs or other lesions or to
areas contaminated with mud or manure.
(<1 animal / 10,000 animals treated,
including isolated reports):
Neurological signs
(e.g. ataxia,
blindness, recumbency)
Gastrointestinal signs (e.g. anorexia,
diarrhoea)
Death
1
When there is an adverse event in a herd, several animals may be
affected. Should neurological signs be observed in one animal, it is
recommended to reinforce surveillance, at the herd level, of all treated animals.
In extreme cases.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
risk of development of resistance and could ultimately result in ineffective therapy:
Too frequent and repeated use of anthelmintics from the same class, over an
extended period of time.
Underdosing which may be due to underestimation of bodyweight,
misadministration of the product, or lack of calibration of the dosing device.
The effect of rain on the pour-on formulation at the time of and after application
has not been investigated. For maximum effect animals should be kept indoors or
undercover following treatment, when there is rain or an imminent risk of rain.
Suspected clinical cases of resistance to anthelmintics should be further
investigated using appropriate tests (e.g., Faecal Egg Count Reduction Test).
Where the results of the tests strongly suggest resistance to a particular
anthelmintic, an anthelmintic belonging to another pharmacological class and
having a different mode of action should be used.
Special precautions for safe use in the target species:
Care should be taken to ensure animals are not overdosed by the application
volume, accidental spillage or oral ingestion, as overdosage may result in signs
of toxicity such as incoordination and blindness. It is recommended that animals
are not clipped prior to treatment to reduce the risk of increased drug absorption
and hence bioavailability, or oral ingestion through mutual grooming.
Due to the significant likelihood of cross-contamination of non-treated animals
with this veterinary medicinal product due to grooming (licking), all animals in a
group should be treated at the same time and treated animals should be kept
separately from non-treated animals throughout the withdrawal period. Non-
compliance with this recommendation may lead to residues violations (see
section 3.12) or in very rare cases, it can lead to adverse events (see section
3.6) in non-treated animals.
AN: 04362/2024 & 04363/2024
Care should be taken when treating animals which may be of low nutritional
status as this may increase susceptibility of adverse events occurring.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
The veterinary medicinal product may be toxic after accidental ingestion. Avoid
ingestion by hand-to-mouth contact. In case of accidental ingestion, seek
medical advice immediately and show the package leaflet or the label to the
physician.
The veterinary medicinal product may cause irritation to human skin and eyes.
The veterinary medicinal product may cause hypersensitivity (allergic) reactions
in those known to be sensitised to polyethylene glycols (PEGs), povidones,
isopropyl alcohol, triethanolamine, ethanol, and/or closantel.
People with known hypersensitivity to closantel or any of the excipients should
avoid contact with the veterinary medicinal product.
Avoid skin or eye contact with the veterinary medicinal product.
Personal protective equipment consisting of nitrile rubber gloves and boots with a
waterproof coat should be worn when handling the veterinary medicinal product.
If accidental skin contact occurs, wash the affected area immediately with soap
and water. If accidental eye exposure occurs, flush the eyes immediately with
water and seek medical attention. Wash any exposed skin after use. Protective
clothing should be washed after use.
The veterinary medicinal product is flammable.
Keep away from heat, sparks, open flame or other sources of ignition.
Store in a closed cabinet. Do not smoke or eat while handling the veterinary
medicinal product.
The veterinary medicinal product contains volatile organic solvents, which may
be accidentally inhaled.
Use only in well-ventilated areas or outdoors.
Special precautions for the protection of the environment:
The veterinary medicinal product is very toxic to aquatic organisms and dung
insects.
Long term effects on dung insects caused by continuous or repeated use cannot
be excluded therefore repeat treatments on a pasture within a season should
only be given on the advice of a veterinarian.
AN: 04362/2024 & 04363/2024
None known.
Store upright in original container in order to protect from light.
If stored at temperatures below 0C, the veterinary medicinal product may
appear cloudy. Allowing to warm at room temperature will restore the normal
appearance without affecting efficacy.
Flammable – keep away from heat, sparks, open flame or other sources of
ignition.
section 3.12) or in very rare cases, it can lead to adverse events (see section
3.6) in non-treated animals.
AN: 04362/2024 & 04363/2024
Care should be taken when treating animals which may be of low nutritional
status as this may increase susceptibility of adverse events occurring.
Special precautions to be taken by the person administering the veterinary
medicinal product to animals
The veterinary medicinal product may be toxic after accidental ingestion. Avoid
ingestion by hand-to-mouth contact. In case of accidental ingestion, seek
medical advice immediately and show the package leaflet or the label to the
physician.
The veterinary medicinal product may cause irritation to human skin and eyes.
The veterinary medicinal product may cause hypersensitivity (allergic) reactions
in those known to be sensitised to polyethylene glycols (PEGs), povidones,
isopropyl alcohol, triethanolamine, ethanol, and/or closantel.
People with known hypersensitivity to closantel or any of the excipients should
avoid contact with the veterinary medicinal product.
Avoid skin or eye contact with the veterinary medicinal product.
Personal protective equipment consisting of nitrile rubber gloves and boots with a
waterproof coat should be worn when handling the veterinary medicinal product.
If accidental skin contact occurs, wash the affected area immediately with soap
and water. If accidental eye exposure occurs, flush the eyes immediately with
water and seek medical attention. Wash any exposed skin after use. Protective
clothing should be washed after use.
The veterinary medicinal product is flammable.
Keep away from heat, sparks, open flame or other sources of ignition.
Store in a closed cabinet. Do not smoke or eat while handling the veterinary
medicinal product.
The veterinary medicinal product contains volatile organic solvents, which may
be accidentally inhaled.
Use only in well-ventilated areas or outdoors.
Special precautions for the protection of the environment:
The veterinary medicinal product is very toxic to aquatic organisms and dung
insects.
Long term effects on dung insects caused by continuous or repeated use cannot
be excluded therefore repeat treatments on a pasture within a season should
only be given on the advice of a veterinarian.
AN: 04362/2024 & 04363/2024
3.6 Adverse events
Very rare
(<1 animal / 10,000 animals treated,
including isolated reports):
Neurological signs
(e.g. ataxia,
blindness, recumbency)
Gastrointestinal signs (e.g. anorexia,
diarrhoea)
Death
1
When there is an adverse event in a herd, several animals may be
affected. Should neurological signs be observed in one animal, it is
recommended to reinforce surveillance, at the herd level, of all treated animals.
In extreme cases.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a
veterinarian, to either the marketing authorisation holder or the national
competent authority via the national reporting system. See the package leaflet for
respective contact details.
3.7 Use during pregnancy, lactation or lay
Pregnancy and lactation:
Can be used during pregnancy or lactation provided that the milk is not intended
for human consumption. See Section 3.12.
3.8 Interaction with other medicinal products and other forms of
interaction
None known.
3.9 Administration routes and dosage
Pour-on use.
Single administration only.
The veterinary medicinal product should be administered topically at a dosage
rate of 20 mg closantel per kg bodyweight (1 ml per 10 kg).
The formulation should be applied along the midline of the back in a narrow strip
between the withers and the tail head.
Assess bodyweight carefully prior to administration.
The timing for treatment should be based on epidemiological factors and should
be customised for each individual farm. The veterinary medicinal product should
not be repeatedly applied to cattle within 10 weeks of first administration.
AN: 04362/2024 & 04363/2024
Handy Dosing Guide
Animals should be weighed and grouped
according to bodyweight to avoid under
or over-dosing
Number of Full Doses per Pack
BodyweightDose Volume
1 Litre2.5 Litre5 Litre100 kg*10 ml100250500150 kg15 ml66166333200 kg20 ml50125250250 kg25 ml40100200300 kg30 ml3383166350 kg35 ml2871142400 kg40 ml2562125450 kg45 ml2255111500 kg50 ml2050100550 kg55 ml184590600 kg60 ml164183
* Dose rate 1 ml per 10 kg bodyweight
3.10 Symptoms of overdose (and where applicable, emergency procedures
and antidotes)
At doses of three times the recommended dose, no significant clinical signs were
recorded.
Closantel like other salicylanilides is a potent uncoupler of oxidative
phosphorylation and the safety index is not as high as is the case of many other
anthelmintics. Signs of overdosage can include slight loss of appetite, loose
faeces, decreased vision and increased frequency of defecation. High doses
may cause blindness, hyperventilation, general weakness and inco-ordination,
hyperthermia, convulsions, tachycardia and in extreme cases death. Treatment
of overdosage is symptomatic as no antidote has been identified.
3.11 Special restrictions for use and special conditions for use, including
restrictions on the use of antimicrobial and antiparasitic veterinary
medicinal products in order to limit the risk of development of
resistance
Not applicable.
3.12 Withdrawal periods
Meat and offal: 63 days.
Not authorised for use in cattle producing milk for human consumption, including
during the dry period. Do not use during the second half of pregnancy in heifers
which are intended to produce milk for human consumption.
AN: 04362/2024 & 04363/2024
Because of the potential for cross-contamination of non-treated animals with the
veterinary medicinal product due to grooming (licking), all animals in a group
should be treated at the same time and treated animals should be kept
separately from non-treated animals throughout the withdrawal period. Non-
compliance with this recommendation may lead to residue violations in non-
treated animals.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Other Products Containing Closantel
These products share the same active ingredient and may be suitable alternatives. Always consult your vet.
Closamectin 5 mg/ml + 200 mg/ml Pour-on Solution for Cattle
POM-VPSNorbrook Laboratories Limited
Closamectin 5 mg/ml + 200 mg/ml Pour-on Solution for Cattle
POM-VPSNorbrook Laboratories Limited
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POM-VPSNorbrook Laboratories Limited
Closamectin Solution for Injection for Cattle
POM-VPSNorbrook Laboratories Limited
Closamectin Solution for Injection for Cattle
POM-VPSNorbrook Laboratories Limited
Closiver 5 mg/ml + 125 mg/ml Solution for Injection for Sheep
POM-VPSNorbrook Laboratories Limited
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