POM-V Prescription Required

Primun Salmonella T Lyophilisate for Use in Drinking Water for Chickens

Active ingredient: Salmonella typhimurium

Form

Lyophilisate

Species

Chickens

Manufacturer

Laboratorios Calier, S.A.

VMD MA No.

20634/5000

What it's used for

Active immunisation of chickens (future layers and breeders) to reduce faecal excretion and colonisation of internal organs with Salmonella Typhimurium fie...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Salmonella typhimurium

1

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2

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Prescription required

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Clinical information

Primun Salmonella T Lyophilisate for Use in Drinking Water for Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 26 Mar 2026.

Active immunisation of chickens (future layers and breeders) to reduce faecal excretion and
colonisation of internal organs with Salmonella Typhimurium field strains.
Onset of immunity: 14 days after first vaccination.
Duration of immunity: 61 weeks after the third vaccination, when used according to the
recommended vaccination schedule.

None.

None known.
Reporting adverse events is important. It allows continuous safety monitoring of a veterinary
medicinal product. Reports should be sent, preferably via a veterinarian, to either the
marketing authorisation holder or its local representative or the national competent authority
via the national reporting system. See also the last section of the package leaflet for contact
details.

Issued: November 2023
AN: 03092/2021

Vaccinate healthy animals only.

Issued: November 2023
AN: 03092/2021

The vaccine strain is highly sensitive to quinolone antibiotics and has increased sensitivity
to enrofloxacin, chloramphenicol, doxycycline, detergents and environmental noxae.
The differentiation between vaccine and field strains is done by means of an antibiogram.
In contrast to field strains, vaccine strains are sensitive to enrofloxacin (recommended
concentration 0.5 µg/ml) and resistant to streptomycin (recommended concentration 50-100
µg/ml) and rifampicin (recommended concentration 5-10 µg/ml).
Depending on the test system used, oral vaccination may result in low seropositive reactions
of individual birds in a flock. Since serological monitoring is a flock test only,
positive findings have to be confirmed, e.g., by bacteriology.
Special precautions for use in animals
Vaccinated chickens may excrete the vaccine strain up to 28 days following vaccination.
During this time, the contact of immunosuppressed and unvaccinated chickens with
vaccinated chickens should be avoided.
Appropriate veterinary and husbandry measures should be taken to avoid spread of the
vaccine strain to susceptible species. An effective rodent control program should be
established, as infected mice may also spread the vaccine strain.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Personal protective equipment consisting of gloves should be worn when handling the
veterinary medicinal product.
Open the vaccine vials under water to avoid aerosols. Disinfect and wash hands after
handling vaccine. Do not ingest.
In case of accidental ingestion seek medical advice immediately and show the package
leaflet or the label to the physician.
The vaccine strain can be found in the environment for up to 28 days. Personnel involved in
attending vaccinated birds should follow general hygiene principles (changing clothes,
wearing gloves, cleaning and disinfection of boots) and take particular care in handling
animal waste and bedding materials from recently vaccinated birds.
Immunocompromised persons are advised to avoid contact with the vaccine and vaccinated
animals during 28 days after vaccination.
The veterinary medicinal product should not be administered by pregnant women.
Other precautions
Not applicable

Since the vaccine strain consists of live bacteria, no antimicrobials should be used within 3
days before and after immunisation with the vaccine. However, if this is inevitable, the flock
must be re-immunised. A decision to use this vaccine before or after any chemotherapeutic
treatment needs to be taken on a case-by-case basis.
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product, so a decision to use this vaccine before or after any other
veterinary medicinal product therefore needs to be made on a case-by-case basis.

Store and transport refrigerated (2
o
C – 8
o
C).
Protect from light.

Issued: November 2023
AN: 03092/2021

Meat and offal: 28 days.
5. IMMUNOLOGICAL PROPERTIES
Pharmacotherapeutic group
fowls.
ATCvet code: QI01AE01.
Primun Salmonella T stimulates active immunity to Salmonella Thyphimurium.
The vaccine strain is a natural metabolic drift mutant, i.e., it lacks or does not express certain
metabolic pathways, which result in attenuation. The genetic basis results in defective
ribosomal protein S12 affecting polypeptide synthesis (streptomycin resistance) and
defective RNA polymerase affecting transcription of DNA to RNA (rifampicin resistance).
The vaccine strain also has attenuations that increase the permeability of the cell membrane
for harmful agents such as detergents and antibiotics. This means the strain has poor
survival in the environment and is highly sensitive to fluoroquinolones and unlike field strains
is sensitive to enrofloxacin.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.