POM-V Prescription Required

AviPro Salmonella Vac T Lyophilisate for Use in Drinking Water

Active ingredient: Salmonella typhimurium

Form

Lyophilisate

Species

Chickens

Manufacturer

Elanco GmbH

VMD MA No.

52127/3078

What it's used for

Onset of immunity: within 15 days of first vaccination. Duration of immunity (breeders and layers): 46 weeks from the time of the last vaccination when use...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Salmonella typhimurium

1

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They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

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Prescription required

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Clinical information

AviPro Salmonella Vac T Lyophilisate for Use in Drinking Water — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity: within 15 days of first vaccination.
Duration of immunity (breeders and layers): 46 weeks from the time of the last
vaccination when used according to the recommended vaccination schedule.
Duration of immunity (broilers): for at least 6 weeks after one vaccination.

Dosage and use:
One dose should be administered per animal.
The vaccine may be used from the 1st day of life.
Recommended vaccination scheme:
Broiler: A single dose from one day of age.
Layers/Breeders: A single dose from one day of age followed by a second
vaccination at 7 weeks of age and a third vaccination at 16 weeks at least 3 weeks
before onset of lay.
Drinking water
Make sure that all conduit pipes, tubing, troughs, drinkers etc. are thoroughly clean
and free of any trace of disinfectants, detergents, soap etc.
Use only cold, clean and fresh water, preferably non-chlorinated and free from metal
ions.
Open the vaccine ampoule under water and dissolve contents thoroughly. As the
concentrated vaccine is slightly viscous, care should be taken to empty the ampoule
completely by rinsing it in water.
Then thoroughly dissolve in a 1 litre jug and stir well before mixing with more water in
a 10 litre bucket before application. Vaccine must be stirred thoroughly for several
minutes at each stage. Determine the number of vaccine doses and amount of water
(see below) required. Do not split large vials to vaccinate more than 1 house or
drinking system, as this may lead to mixing errors.
As a guide apply diluted vaccine to cold and fresh water at the rate of 1 litre of water
per 1,000 birds per day of age, e.g. 10 litres would be needed for 1,000 10 day old
chickens. Use water meter recordings for the previous day to accurately determine
the correct quantity of water in each case. Low-fat skimmed milk powder (i.e. < 1 %
fat) should be added to the water (2 – 4 g per litre) or skimmed milk (20-40 ml/litre of
water) to increase the stability of the vaccine.
The admixture should be added to the vaccine in any case 10 minutes before. All
tubing should be emptied of plain water, so that the drinkers contain only vaccine
water.
Allow water in the drinkers to be consumed so that levels prior to vaccine application
are minimal. If water is still present the lines must be drained before applying the
vaccine. The vaccine treated water should be applied for up to 4 hours. It should be
ensured that all birds drink during this period. Birds drinking behaviour varies. It may
be necessary to withhold drinking water on some sites prior to vaccination in order to
ensure that all birds drink during the vaccination period. The aim is to give every bird
one dose of vaccine. A period of thirst of up to 2 – 3 hours before vaccination may be
necessary to achieve this.
Ideally, birds should consume the vaccine that was reconstituted in drinking water
within 4 hours.
In case of doubt, the water consumption must be determined on the day before
vaccination.
- Administer the dissolved vaccine to birds immediately.
- Make sure that birds do not have access to unmedicated water during vaccination.
- Avoid exposure of the vaccine suspension to sunlight.

None.

None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian,
to either the marketing authorisation holder or the national competent authority via
the national reporting system. See the package leaflet for respective contact details.

Vaccinate healthy animals only.
In the presence of maternally derived antibodies, a single minimum dose of vaccine
administered at one day of age protects against systemic infection with
Typhimurium field strain, but no information on shedding is available.
Not tested on ornamental and pure-bred poultry.

Special precautions for safe use in the target species:
The vaccine strain is sensitive to fluoroquinolone antibiotics and has increased
sensitivity to erythromycin, chloramphenicol, doxycycline, detergents and
environmental noxae.
Vaccinated birds may excrete the vaccine strain up to 14 days following a single
vaccination at one day of age.
The vaccine strain can spread to susceptible birds in contact with vaccinated
chickens.
Depending on the test system used, oral vaccination may result in low seropositive
reactions of individual birds in a flock. Since serological monitoring is a
flock test only, positive findings must be confirmed, e.g. by bacteriology.
The differentiation between vaccine and field strains is made by means of an
antibiogram. In contrast to field strains, vaccine strains are sensitive to erythromycin
(re-commended concentration 15 – 30 µg/ml) and resistant to nalidixic acid
(recommended concentration 20 µg/ml) and rifampicin (recommended concentration
200 µg/ml).
The vaccine strain can also be distinguished from field strains by molecular biology
methods, such as a polymerase chain reaction (PCR) method. For detailed
information, please contact the marketing authorisation holder.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
Use gloves when reconstituting the vaccine. Open vial under water to avoid
aerosols. Use impervious arm length gloves when mixing vaccine in a bucket or
header tank. Disinfect and wash hands after handling vaccine. Do not ingest. In case
of accidental ingestion, seek medical advice immediately and show the package
leaflet or the label to the physician. The vaccine strain is sensitive to a number of
antibiotics including fluoroquinolones (ciprofloxacin).
Since this vaccine has been prepared with live, attenuated microorganisms,
appropriate measures should be taken to prevent contamination of the handler and
other people that collaborate in the process.
Care should be taken to wash and disinfect hands after handling poultry faeces,
particularly in the first 14 days after vaccination of birds. Personnel involved in
attending vaccinated birds should follow general hygiene principles (changing
clothes, wearing gloves, cleaning and disinfection of boots) and take particular care
in handling waste and bedding materials from recently vaccinated birds.
Immunocompromised persons are advised to avoid contact with the vaccine and
vaccinated animals during the excretion of the vaccine strain.
The veterinary medicinal product should not be administered by pregnant women.
Special precautions for the protection of the environment:
Not applicable.

Since the vaccine strain is a live bacterium, simultaneous use of chemotherapeutics
which are effective against Salmonella should be avoided.
However, if treatment with chemotherapeutics is inevitable, the flock must be re-
immunized. A decision to use this vaccine before or after any chemotherapeutic
treatment needs to be taken on a case-by-case basis.
Safety and efficacy data are available which demonstrate that this vaccine can be
administered on the same day but not mixed with AviPro SALMONELLA VAC E.
No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medicinal product except the products mentioned above. A
decision to use this vaccine before or after any other veterinary medicinal product
therefore needs to be made on a case-by-case basis.

Store and transport refrigerated (2 C – 8 C).
Do not freeze.
Protect from light.

Meat, offal and eggs: 21 days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.