POM-V
Prescription Required
AviPro Salmonella Duo Lyophilisate for Use in Drinking Water
Active ingredients: Salmonella enteritidis, Salmonella typhimurium
Form
Lyophilisate
Species
Chickens
Duck
Turkeys
Manufacturer
Elanco GmbH
VMD MA No.
52127/3005
What it's used for
Onset of immunity: 15 days after first vaccination. Duration of immunity: After 3 rd vaccination when used according to the recommended vaccination schedul...
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Clinical information
AviPro Salmonella Duo Lyophilisate for Use in Drinking Water — SPC Details
Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.
Onset of immunity: 15 days after first vaccination.
Duration of immunity:
After 3
rd
vaccination when used according to the recommended vaccination schedule:
52 weeks against virulent S. Enteritidis and 46 weeks against virulent S. Typhimurium
After 4
th
vaccination when used according to the recommended vaccination schedule:
50 weeks against virulent S. Enteritidis and 44 weeks against virulent S. Typhimurium
Turkey future breeders and turkeys for meat production:
For active immunisation of healthy and susceptible turkeys to reduce colonisation of
internal organs with SalmonellaSalmonella
In general, the colonisation of internal organs of vaccinated turkeys with challenge bacteria
is reduced compared to unvaccinated turkeys; a statistically significant reduction could not
be shown in all instances.
Onset of immunity: 21 days after first vaccination.
Duration of immunity:
Future breeders: 30 weeks against virulent Salmonella
virulent Salmonella
according to the recommended vaccination schedule.
Turkeys for meat production: 10 weeks against virulent Salmonella
virulent Salmonella
according to the recommended vaccination schedule.
Ducks for meat production:
For active immunisation of healthy and susceptible ducks to reduce colonisation of internal
organs with Salmonella Typhimurium field strains.
Onset of immunity: 22 days.
Duration of immunity: 43 days.
Duration of immunity:
After 3
rd
vaccination when used according to the recommended vaccination schedule:
52 weeks against virulent S. Enteritidis and 46 weeks against virulent S. Typhimurium
After 4
th
vaccination when used according to the recommended vaccination schedule:
50 weeks against virulent S. Enteritidis and 44 weeks against virulent S. Typhimurium
Turkey future breeders and turkeys for meat production:
For active immunisation of healthy and susceptible turkeys to reduce colonisation of
internal organs with SalmonellaSalmonella
In general, the colonisation of internal organs of vaccinated turkeys with challenge bacteria
is reduced compared to unvaccinated turkeys; a statistically significant reduction could not
be shown in all instances.
Onset of immunity: 21 days after first vaccination.
Duration of immunity:
Future breeders: 30 weeks against virulent Salmonella
virulent Salmonella
according to the recommended vaccination schedule.
Turkeys for meat production: 10 weeks against virulent Salmonella
virulent Salmonella
according to the recommended vaccination schedule.
Ducks for meat production:
For active immunisation of healthy and susceptible ducks to reduce colonisation of internal
organs with Salmonella Typhimurium field strains.
Onset of immunity: 22 days.
Duration of immunity: 43 days.
Advice on correct administration:
The contents of opened vial should be used completely.
Prepare only the amounts of the vaccine that will be used within 4 hours.
Protect the reconstituted vaccine from direct sunlight, frost and temperatures above 25 °C.
Follow these instructions for correct administration, so that all birds receive the appropriate
dose.
Vaccination scheme:
AviPro Salmonella Duo may be used from the first day of life.
Ducks for meat production: A single dose from first day of life.
Chickens (breeders and layers): A single dose from first day of life followed by a second
vaccination at an age of 6 to 8 weeks and a third vaccination around the 16
th
week of life at
least 3 weeks before onset of lay. A fourth vaccination is recommended during the laying
period around the 50
th
week of life to provide extended protection.
Turkeys for meat production: A single dose from the first day of life followed by a second
vaccination at an age of 6 weeks.
Turkey future breeders: A single dose from the first day of life followed by a second
vaccination at an age of 6 weeks, a third vaccination at an age of 16 weeks and a fourth
vaccination at an age of 23-24 weeks.
Administration via the drinking water:
1. Determination of the required amount of water:
•
the birds within 3 hours. Use water meter recording for the previous day to
accurately determine the correct quantity of water in each case. Alternatively,
the amount of water needed can be calculated out of the number and age of
birds combined with the information given in the water consumption tables from
the breeding companies.
•
chickens, especially in the case of older turkeys, this amount might need to be
increased to ensure sufficient water uptake of each bird.
2. Resuspension of the lyophilisate:
•
splitting may lead to dosing errors.
•
thoroughly cleaned and free of detergent and disinfectant residues.
•
Skimmed milk powder (<1% fat) (2–4 grams per litre of water) or skimmed milk
(20–40 ml per litre of water) can improve the quality of tap water and thus the
stability of the vaccine. However, this has to be done at least 10 minutes prior to
adding the vaccine.
•
vaccine is slightly viscous, care should be taken to empty the ampoule and its
top completely by rinsing them in water. Vaccine solution must be stirred
thoroughly for several minutes before administration.
3. Application of the resuspended vaccine:
•
applications are minimal. If water is still present, the lines must be drained
before applying the vaccine.
•
that all birds drink during this time. Due to the varying drinking behaviour of
chickens, it might be necessary to withhold water on some sites prior to
vaccination in order to ensure that all birds drink during the vaccination period.
•
ensure that every bird receives a vaccine dose.
•
vaccination.
The contents of opened vial should be used completely.
Prepare only the amounts of the vaccine that will be used within 4 hours.
Protect the reconstituted vaccine from direct sunlight, frost and temperatures above 25 °C.
Follow these instructions for correct administration, so that all birds receive the appropriate
dose.
Vaccination scheme:
AviPro Salmonella Duo may be used from the first day of life.
Ducks for meat production: A single dose from first day of life.
Chickens (breeders and layers): A single dose from first day of life followed by a second
vaccination at an age of 6 to 8 weeks and a third vaccination around the 16
th
week of life at
least 3 weeks before onset of lay. A fourth vaccination is recommended during the laying
period around the 50
th
week of life to provide extended protection.
Turkeys for meat production: A single dose from the first day of life followed by a second
vaccination at an age of 6 weeks.
Turkey future breeders: A single dose from the first day of life followed by a second
vaccination at an age of 6 weeks, a third vaccination at an age of 16 weeks and a fourth
vaccination at an age of 23-24 weeks.
Administration via the drinking water:
1. Determination of the required amount of water:
•
the birds within 3 hours. Use water meter recording for the previous day to
accurately determine the correct quantity of water in each case. Alternatively,
the amount of water needed can be calculated out of the number and age of
birds combined with the information given in the water consumption tables from
the breeding companies.
•
chickens, especially in the case of older turkeys, this amount might need to be
increased to ensure sufficient water uptake of each bird.
2. Resuspension of the lyophilisate:
•
splitting may lead to dosing errors.
•
thoroughly cleaned and free of detergent and disinfectant residues.
•
Skimmed milk powder (<1% fat) (2–4 grams per litre of water) or skimmed milk
(20–40 ml per litre of water) can improve the quality of tap water and thus the
stability of the vaccine. However, this has to be done at least 10 minutes prior to
adding the vaccine.
•
vaccine is slightly viscous, care should be taken to empty the ampoule and its
top completely by rinsing them in water. Vaccine solution must be stirred
thoroughly for several minutes before administration.
3. Application of the resuspended vaccine:
•
applications are minimal. If water is still present, the lines must be drained
before applying the vaccine.
•
that all birds drink during this time. Due to the varying drinking behaviour of
chickens, it might be necessary to withhold water on some sites prior to
vaccination in order to ensure that all birds drink during the vaccination period.
•
ensure that every bird receives a vaccine dose.
•
vaccination.
None.
None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.
Vaccinate healthy animals only.
In chickens, protection in the presence of maternally derived antibodies has been shown
with a vaccine containing Salmonella Enteritidis but no information is available on the
Salmonella Typhimurium component.
In turkeys, the influence of maternally derived antibodies was not studied.
The prevalence of Salmonella Enteritidis and Salmonella Typhimurium in commercial
turkey holdings can vary widely amongst the European Union Member States. The vaccine
should only be used on turkey farms with known occurrence of Enteritidis or
Salmonella Typhimurium unless national Salmonella control programs in European Union
Member States promote control measures such as vaccination.
In ducks, the maternally derived antibodies may have an impact on the development of the
immune response.
Special precautions for safe use in the target species:
Vaccinated chickens may excrete the vaccine strains for at least 42days following the first
and second vaccination. For the S. Enteritidis vaccine strain, no excretion and no organ
spread could be detected after the third and fourth vaccination. For the S. Typhimurium
vaccine strain, extended excretion up to 19 weeks after the third vaccination may be
possible. No spread to organs including the oviduct was observed from two weeks after
the third vaccination. No excretion or organ spread of the S. Typhimurium vaccine strain
could be detected after the fourth vaccination.
Vaccinated ducks may excrete the Salmonella Enteritidis vaccine strain up to 14 days and
the Salmonella Typhimurium vaccine strain up to 28 days following vaccination.
Shedding of Salmonella vaccine strains in turkeys is intermittent. After vaccinated once at
the first day of life, duration of excretion was observed for the Salmonella Enteritidis
vaccine strain up to day 49 and for the Salmonella Typhimurium vaccine strain up to day
63. After repeated vaccinations duration of excretion is shortened. Due to limited data, the
eggs of vaccinated turkey breeders are not intended for human consumption.
Not tested on ornamental and pure-bred poultry.
The vaccine can spread to susceptible birds in contact with vaccinated birds.
On very rare occasions, the vaccine strains may be isolated from the environment beyond
the above-mentioned period when using very sensitive detection methods.
Ensure that the drinking water is free of detergents, disinfectants and acids.
The vaccine strains are highly sensitive to fluoroquinolone antibiotics and have increased
sensitivity to erythromycin, chloramphenicol, doxycycline, detergents and environmental
noxae.
The differentiation between the vaccine and field strains is achieved by means of an
antibiogram:
•Enteritidis:
In contrast to field strains, the vaccine strain is sensitive to erythromycin (recommended
concentration 15–30 µg/ml) and resistant to streptomycin (recommended concentration
200 µg/ml) and rifampicin (recommended concentration 200 µg/ml).
•Typhimurium:
In contrast to field strains, the vaccine strain is sensitive to erythromycin (recommended
concentration 15–30 µg/ml) and resistant to nalidixic acid (recommended concentration
20 µg/ml) and rifampicin (recommended concentration 200 µg/ml).
The vaccine strains can also be distinguished from field strains by molecular biology
methods, such as a real-time polymerase chain reaction (PCR) method. For detailed
information, please contact the marketing authorisation holder.
Depending on the test system used, oral vaccination may result in low seropositive
reactions of individual birds in a flock. Since the serological monitoring of Salmonella
only a flock test, positive findings have to be confirmed, e.g. by bacteriology.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Personal protective equipment consisting of gloves should be worn when handling the
veterinary medicinal product.
Open the vial only under water to avoid aerosols.
Wash and disinfect hands after handling the vaccine.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and show
the package leaflet or the label to the physician.
The vaccine strains are sensitive to a number of antibiotics including quinolones
(ciprofloxacin).
Since the vaccine has been prepared with live, attenuated microorganisms, appropriate
measures should be taken to prevent contamination of the handler and other people that
collaborate in the process.
Vaccinated animals may excrete the vaccine strains. Immunocompromised persons are
advised to avoid contact with the vaccine and recently vaccinated animals.
The veterinary medicinal product should not be administered by pregnant women.
Personnel involved in attending vaccinated animals should follow general hygiene
principals (changing clothes, wearing gloves, cleaning and disinfection of boots) and take
particular care in handling animal waste and bedding material from vaccinated chickens up
to 19 weeks after vaccination, from vaccinated ducks until 28 days after vaccination and
from vaccinated turkeys until 63 days after vaccination.
Special precautions for the protection of the environment:
Not applicable.
In chickens, protection in the presence of maternally derived antibodies has been shown
with a vaccine containing Salmonella Enteritidis but no information is available on the
Salmonella Typhimurium component.
In turkeys, the influence of maternally derived antibodies was not studied.
The prevalence of Salmonella Enteritidis and Salmonella Typhimurium in commercial
turkey holdings can vary widely amongst the European Union Member States. The vaccine
should only be used on turkey farms with known occurrence of Enteritidis or
Salmonella Typhimurium unless national Salmonella control programs in European Union
Member States promote control measures such as vaccination.
In ducks, the maternally derived antibodies may have an impact on the development of the
immune response.
Special precautions for safe use in the target species:
Vaccinated chickens may excrete the vaccine strains for at least 42days following the first
and second vaccination. For the S. Enteritidis vaccine strain, no excretion and no organ
spread could be detected after the third and fourth vaccination. For the S. Typhimurium
vaccine strain, extended excretion up to 19 weeks after the third vaccination may be
possible. No spread to organs including the oviduct was observed from two weeks after
the third vaccination. No excretion or organ spread of the S. Typhimurium vaccine strain
could be detected after the fourth vaccination.
Vaccinated ducks may excrete the Salmonella Enteritidis vaccine strain up to 14 days and
the Salmonella Typhimurium vaccine strain up to 28 days following vaccination.
Shedding of Salmonella vaccine strains in turkeys is intermittent. After vaccinated once at
the first day of life, duration of excretion was observed for the Salmonella Enteritidis
vaccine strain up to day 49 and for the Salmonella Typhimurium vaccine strain up to day
63. After repeated vaccinations duration of excretion is shortened. Due to limited data, the
eggs of vaccinated turkey breeders are not intended for human consumption.
Not tested on ornamental and pure-bred poultry.
The vaccine can spread to susceptible birds in contact with vaccinated birds.
On very rare occasions, the vaccine strains may be isolated from the environment beyond
the above-mentioned period when using very sensitive detection methods.
Ensure that the drinking water is free of detergents, disinfectants and acids.
The vaccine strains are highly sensitive to fluoroquinolone antibiotics and have increased
sensitivity to erythromycin, chloramphenicol, doxycycline, detergents and environmental
noxae.
The differentiation between the vaccine and field strains is achieved by means of an
antibiogram:
•Enteritidis:
In contrast to field strains, the vaccine strain is sensitive to erythromycin (recommended
concentration 15–30 µg/ml) and resistant to streptomycin (recommended concentration
200 µg/ml) and rifampicin (recommended concentration 200 µg/ml).
•Typhimurium:
In contrast to field strains, the vaccine strain is sensitive to erythromycin (recommended
concentration 15–30 µg/ml) and resistant to nalidixic acid (recommended concentration
20 µg/ml) and rifampicin (recommended concentration 200 µg/ml).
The vaccine strains can also be distinguished from field strains by molecular biology
methods, such as a real-time polymerase chain reaction (PCR) method. For detailed
information, please contact the marketing authorisation holder.
Depending on the test system used, oral vaccination may result in low seropositive
reactions of individual birds in a flock. Since the serological monitoring of Salmonella
only a flock test, positive findings have to be confirmed, e.g. by bacteriology.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Personal protective equipment consisting of gloves should be worn when handling the
veterinary medicinal product.
Open the vial only under water to avoid aerosols.
Wash and disinfect hands after handling the vaccine.
Do not ingest. In case of accidental ingestion, seek medical advice immediately and show
the package leaflet or the label to the physician.
The vaccine strains are sensitive to a number of antibiotics including quinolones
(ciprofloxacin).
Since the vaccine has been prepared with live, attenuated microorganisms, appropriate
measures should be taken to prevent contamination of the handler and other people that
collaborate in the process.
Vaccinated animals may excrete the vaccine strains. Immunocompromised persons are
advised to avoid contact with the vaccine and recently vaccinated animals.
The veterinary medicinal product should not be administered by pregnant women.
Personnel involved in attending vaccinated animals should follow general hygiene
principals (changing clothes, wearing gloves, cleaning and disinfection of boots) and take
particular care in handling animal waste and bedding material from vaccinated chickens up
to 19 weeks after vaccination, from vaccinated ducks until 28 days after vaccination and
from vaccinated turkeys until 63 days after vaccination.
Special precautions for the protection of the environment:
Not applicable.
Since the vaccine strains are live bacteria, simultaneous use of chemotherapeutics which
are effective against Salmonella
must be re-immunised. A decision to use this vaccine before or after any
chemotherapeutic treatment needs to be taken on a case-by-case basis.
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medical product. A decision to use this vaccine before or after any other
veterinary medicinal product therefore needs to be made on a case-by-case basis.
are effective against Salmonella
must be re-immunised. A decision to use this vaccine before or after any
chemotherapeutic treatment needs to be taken on a case-by-case basis.
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medical product. A decision to use this vaccine before or after any other
veterinary medicinal product therefore needs to be made on a case-by-case basis.
Store and transport refrigerated (2 C – 8 C).
Do not freeze.
Protect from direct sunlight.
Do not freeze.
Protect from direct sunlight.
For chickens:
meat, offal and eggs: 21 days after the 1
st
, 2
nd
and 3
rd
vaccination; zero days
after the 4
th
vaccination.
For ducks: meat, offal and eggs: 21 days
For turkeys: meat and offal: 70 days after the first vaccination,
49 days after repeated vaccination.
meat, offal and eggs: 21 days after the 1
st
, 2
nd
and 3
rd
vaccination; zero days
after the 4
th
vaccination.
For ducks: meat, offal and eggs: 21 days
For turkeys: meat and offal: 70 days after the first vaccination,
49 days after repeated vaccination.
This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.
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Same active ingredient
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