POM-V Prescription Required

AviPro Salmonella Vac E Lyophilisate for Use in Drinking Water

Active ingredient: Salmonella enteritidis

Form

Lyophilisate

Species

Chickens

Manufacturer

Elanco Europe Ltd

VMD MA No.

00879/5057

What it's used for

Onset of immunity:15 days. Duration of immunity: 6 to 8 weeks following a single dose and 60 weeks following the 3 dose programme.

Full indications, dosage and side effects ↓

View official SPC (PDF)

The prescription itself has a price. See what practices near you charge for a consultation and the written prescription fee.

Paying less for Salmonella enteritidis

1

Ask your vet for a written prescription

They must provide one on request. Under the CMA Order the fee is capped at £21 from 2027.
2

Fill it at a registered online retailer

The CMA found online pharmacies 50–60% cheaper than practice dispensing on common medicines — typically £200–£300 a year.

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Prescription required

Your vet must provide a written prescription on request. You can then purchase from any licensed online retailer.

Clinical information

AviPro Salmonella Vac E Lyophilisate for Use in Drinking Water — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity:15 days.
Duration of immunity: 6 to 8 weeks following a single dose and 60 weeks following the 3
dose programme.

The vaccine may be used from the 1st day of life.
Recommended vaccination scheme:
Broiler: For birds up to 6 weeks of age, a single dose from one day of age.
Layers and Breeders: A single dose from one day of age followed by a second
vaccination at 6 to 8 weeks of age and a third vaccination at 16-18 weeks at least 3
weeks before onsetof lay.
Drinking water:
1. Make sure that all conduit pipes, tubing, troughs, drinkers etc. are thoroughly clean
and free of any trace of disinfectants, detergents, soap etc.
2. Open the vaccine ampoule under water and dissolve thoroughly. As the
concentrated vaccine is slightly viscous, care should be taken to empty the ampoule
completely by rinsing it in water.
3. Then thoroughly dissolve in a 1 litre jug and stir well before mixing with more water
in a 10 litre bucket before application. The vaccine must be stirred thoroughly for several
minutes at each stage. Do not split large vials to vaccinate more than 1 house or
drinking system, as this leads to mixing errors.
4. As a guide, apply the diluted vaccine to cold and fresh water at the rate of 1 liter of
water per 1,000 birds per day of age e.g. 10 litres would be needed for 1,000 10-day old
chickens. Use water meter recordings for the previous day to accurately determine the
correct quantity of water in each case. Low-fat skimmed milk powder (i.e.<1 % fat)
should be added to the water (2-4 g per liter) or skimmed milk (20 - 40 ml per litre of
water) to increase the stability of the vaccine. All tubing should be emptied of plain
water, so that the drinkers contain only vaccine water.
5. Allow water in the drinkers to be consumed so that levels prior to vaccine
applications are minimal. If water is still present the lines must be drained before
applying the vaccine. The vaccine treated water should be used within 4 hours. It should
be ensured that all birds drink during this period. Birds drinking behavior varies. It may
be necessary to withhold drinking water on some sites prior to vaccination in order to
ensure that all birds drink during the vaccination period. The aim is to give every bird one
dose of vaccine. A period of thirst of up to 2-3 hours before vaccination may be
necessary to achieve this.

None.

None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

Vaccinate healthy animals only.

Special precautions for safe use in the target species:
The vaccine strain is highly sensitive to quinolone antibiotics and has increased
sensitivity to erythromycin, chloramphenicol, doxycycline, detergents and environmental
noxae.
The vaccine strain can spread to susceptible birds in contact with vaccinated chickens.
Vaccinated birds may excrete the vaccine strain for up to 16 days following vaccination.
The differentiation between vaccine and field strains is done by means of an
antibiogram. In contrast to field strains, vaccine strains are sensitive to erythromycin
(recommended concentration 15-30 µg/ml) and resistant to streptomycin and rifampicin
(recommended concentration 200 µg/ml).
The presence of maternal antibodies to Salmonella
vaccination over the first 4 days of life.
The vaccine strain can also be distinguished from field strains by molecular biology
methods, such as a real-time polymerase chain reaction (PCR) method. For detailed
information, please contact the marketing authorization holder.
Depending on the test system used, oral vaccination may result in low seropositive
reactions of individual birds in a flock. Since serological Salmonella
test only, positive findings have to be confirmed, e.g. by bacteriology.
Special precautions to be taken by the person administering the veterinary medicinal
product to animals
Use gloves when reconstituting the vaccine. Open vial under water to avoid aerosols.
Disinfect and wash hands after handling vaccine. Do not ingest. In case of accidental
ingestion seek medical advice immediately and show the package leaflet or the label to
the physician. The vaccine strain is sensitive to a number of antibiotics including
quinolones (ciprofloxacin).
Care should be taken to wash and disinfect hands after handling poultry faeces,
particularly in the first 7 days after vaccination of birds.
Immunocompromised persons are advised to avoid contact with the vaccine and
recently vaccinated animal.

Antibacterials shall not be administered 3 days before and after immunization.
If antibiotic treatment is inevitable, the respective animals must be re-immunized,
however, not earlier than three days after this treatment.
The vaccine may be administered on the same day as AviPro Salmonella vac T, but not
simultaneously.
No information is available on the safety and efficacy of this vaccine when used with any
other veterinary medicinal product. A decision to use this vaccine before or after any
other veterinary medicinal product therefore needs to be made on a case-by-case basis.

Store in a refrigerator (2 °C - 8 °C).
Do not freeze.
Protect from light

Meat and offal: 21 days.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.