POM-V Prescription Required

Cevac Salmovac Lyophilisate for Use in Drinking Water for Chickens

Active ingredient: Salmonella enteritidis

Form

Lyophilisate

Species

Chickens

Manufacturer

Ceva Sante Animale

VMD MA No.

14966/3003

What it's used for

Onset of immunity within 6 days after first vaccination. Duration of immunity for Enteritidis is 35 weeks after second vaccination and 63 weeks after third...

Full indications, dosage and side effects ↓

View official SPC (PDF)

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Paying less for Salmonella enteritidis

1

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Prescription required

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Clinical information

Cevac Salmovac Lyophilisate for Use in Drinking Water for Chickens — SPC Details

Source: VMD Summary of Product Characteristics (SPC). Last updated 27 Mar 2026.

Onset of immunity within 6 days after first vaccination.
Duration of immunity for Enteritidis is 35 weeks after second vaccination
and 63 weeks after third vaccination when used according to the recommended
vaccination schedule.
Duration of immunity for
vaccination when used according to the recommended vaccination schedule.
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weeks between the second and third administration.
Recommended vaccination scheme for birds on farms with a known history and
absence of Enteritidis according to routine bacteriological monitoring:
One dose from first day of age followed by a second dose two weeks later (but not
later than 6 weeks before the onset of lay). A greater level of protection, with regards
to the duration of immunity, is observed with the 3-dose regime.
Immunisation against Typhimurium
(whatever the salmonella status)
One dose from first day of age, a second dose six weeks later and a third dose
around 13 weeks of age.
Administration in drinking water (oral route).
-Apply the usual aseptic precautions to all administration procedures.
-Calculate the number of vials of vaccine required to vaccinate all the birds.
-Use only clean, antiseptic and disinfectant free drinking water.
-Reconstitute the vaccine using a small volume of drinking water in the vaccine
vial. Ensure the complete dissolution of the lyophilisate. Then add the
reconstituted vaccine to sufficient water to be consumed within 4 hours and mix
thoroughly.
Birds may have drinking water withdrawn for 1-2 hours before administering vaccine.
As a guide, administer the vaccine in a volume of at least 2 litres of drinking water per
1 000 chickens at first vaccination and at least 5 litres of drinking water per 1 000
chickens at second vaccination two weeks later.
If a third dose is administered, use at least 10 – 20 litres of drinking water per 1 000
chickens. This third dose should be administered not later than three weeks before
the laying period.
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Do not use in broilers.

Chickens
None known.
Reporting adverse events is important. It allows continuous safety monitoring of a
veterinary medicinal product. Reports should be sent, preferably via a veterinarian, to
either the marketing authorisation holder or the national competent authority via the
national reporting system. See the package leaflet for respective contact details.

Vaccinate healthy animals only.

Special precautions for safe use in the target species:
Vaccinated chickens excrete the vaccine strain up to six weeks following vaccination.
During this time, the contact of immunosuppressed and unvaccinated chickens with
vaccinated chickens should be avoided. The vaccine can spread to susceptible birds.
Special precautions should be taken to avoid spreading of the vaccine strain to
susceptible birds. Contact chickens may also excrete the vaccine strain.
The vaccine strain has been isolated from chicken litter up to 13 days after
vaccination.
In studies, the vaccine strain can be found in the environment for up to 8 weeks after
the 2nd vaccination and 5 weeks after the 3rd vaccination.
On very rare occasions, the vaccine strain may be isolated from the environment
beyond the above mentioned period.
The vaccine strain has been shown to spread to non-target species such as calves
and pigs. It persisted in these animals and was excreted over a period of 9 days in
calves and 22 days in pigs and has been shown to cause a transient increase in body
temperature.
Appropriate veterinary and husbandry measures should be taken to avoid spread of
the vaccine strain to susceptible species.
The use of the vaccine in fancy breeds has not been studied.
The vaccine strain is among others sensitive to ampicillin, cefotaxime,
chloramphenicol, ciprofloxacin, gentamycin, kanamycin, oxytetracycline,
streptomycin.
The vaccine strain is resistant to sulfamerazine alone but sensitive to sulfamerazine
and trimethoprime in combination.
Due to the adenine-histidine auxotrophy of the vaccine strain, a differentiation
between vaccine and field strains is possible by means of an appropriate growth test
such as the Ceva S-check test.
A clear differentiation between vaccine strain and wild type strain is also possible on
special chromogenic selective media (e.g. ASAP
TM
media, Biomérieux) due to a
different colour of the vaccine colonies versus wild
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The vaccine strain can also be distinguished from field strains by molecular biological
methods, such as real time Polymerase Chain Reaction (PCR) and Restriction
Fragment Length Polymorphism (RFLP) in Pulsed- field Gel Electrophoresis (PFGE).
Special precautions to be taken by the person administering the veterinary medicinal
product to animals:
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician. The vaccine strain is sensitive to
antibiotics with the exception of sulfamerazine.
Use disposable gloves when reconstituting the vaccine. Wash and disinfect hands
after handling vaccine. Do not ingest.
Immunocompromised persons are advised to avoid contact with the vaccine and
vaccinated animals during the period of excretion of the vaccine strain.
Personnel involved in attending vaccinated chickens should follow general hygiene
principles (changing clothes, wearing gloves, cleaning and disinfection of boots) and
take particular care in handling litter from recently vaccinated chickens. Hands should
be washed and disinfected after attending vaccinated chickens.
Special precautions for the protection of the environment:
Not applicable.

No anti-infective substances should be used within 3 days before and after
immunisation with the vaccine. In case of essential administration, the vaccination of
the concerned birds has to be repeated.
No information is available on the safety and efficacy of this vaccine when used with
any other veterinary medical product. A decision to use this vaccine before or after
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any other veterinary medicinal product therefore needs to be made on a case-by-
case basis.
No competitive microflora preparations should be administered concurrently with the
product.

Store in a refrigerator (2 C – 8 C).
Protect from light.
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Meat: 6 weeks
Eggs: 3 weeks
Do not use within 3 weeks before the start of the laying period.

This information is sourced from the official Summary of Product Characteristics (SPC) published by the Veterinary Medicines Directorate (VMD). It is provided for informational purposes only and does not replace professional veterinary advice. Always consult your vet before administering any medication.