Cevac Salmovac Lyophilisate for Use in Drinking Water for Chickens

Vaccinate healthy animals only.

i) Special precautions for use in animals
Vaccinated chickens excrete the vaccine strain up to six weeks following
vaccination. During this time, the contact of immunosuppressed and
unvaccinated chickens with vaccinated chickens should be avoided.
The vaccine can spread to susceptible birds. Special precautions should be
taken to avoid spreading of the vaccine strain to susceptible birds. Contact
chickens may also excrete the vaccine strain.
The vaccine strain has been isolated from chicken litter up to 13 days after
vaccination.
In studies, the vaccine strain can be found in the environment for up to 8 weeks
after the 2
nd
vaccination and 5 weeks after the 3
rd
vaccination.
On very rare occasions, the vaccine strain may be isolated from the
environment beyond the above mentioned period.
The vaccine strain has been shown to spread to non-target species such as
calves and pigs. It persisted in these animals and was excreted over a period of
9 days in calves and 22 days in pigs and has been shown to cause a transient
increase in body temperature.
The use of the vaccine in fancy breeds has not been studied.
The vaccine strain is among others sensitive to ampicillin, cefotaxime,
chloramphenicol, ciprofloxacin, gentamycin, kanamycin, oxytetracycline,
streptomycin.
The vaccine strain is resistant to sulfamerazine alone but sensitive to
sulfamerazine and trimethoprime in combination.
Due to the adenine-histidine auxotrophy of the vaccine strain, a differentiation
between vaccine and field strains is possible by means of an appropriate growth
test such as the Ceva S-check test.
A clear vaccine strain wild type strain differentiation is also possible on special
chromogenic selective media (e.g. ASAP media, Biomérieux) due to a different
colour of the vaccine colonies versus wild SE strains.
The vaccine strain can also be distinguished from the field strain by molecular
biology methods, such as real time Polymerase Chain Reaction (PCR) and
Restriction Fragment Polymorphism (RFLP) in Pulse Gel Electrophoresis
(PFGE).
Appropriate veterinary and husbandry measures should be taken to avoid
spread of the vaccine strain to susceptible species.

Revised: January 2026
AN: 03131/2025Page 3 of 7
ii). Special precautions to be take by the person administering the veterinary
medicinal product to animals
In case of accidental ingestion, seek medical advice immediately and show the
package leaflet or the label to the physician. The vaccine strain is sensitive to
antibiotics with the exception of sulfamerazine.
Use disposable gloves when reconstituting the vaccine. Wash and disinfect
hands after handling vaccine. Do not ingest. If the vaccine has been swallowed
seek medical advice.
Immunocompromised persons are advised to avoid contact with the vaccine
and vaccinated animals during the excretion of the vaccine strain.
Personnel involved in attending vaccinated chickens should follow general
hygiene principles (changing clothes, wearing gloves, cleaning and disinfection
of boots) and take particular care in handling litter from recently vaccinated
chickens. Hands should be washed and disinfected after attending vaccinated
chickens.
iii). Other precautions
Not applicable.