Premadex 10 mg/ml Solution for Injection

The fertility of males is not affected by administration of the product.
4.8 Interaction with other medicinal products and other forms of interaction
Do not combine ivermectin treatment with vaccination against lungworms. If
vaccinated animals are to be treated, treatment should not be carried out within
a period of 28 days before or after vaccination (see section 4.5).

Revised: October 2025
MA split from NI MA following AN: 01927/2025
4.9 Amounts to be administered and administration route
For single administration only (except for the treatment of
infections in sheep).
To ensure administration of a correct dose, bodyweight should be determined as
accurately as possible. Accuracy of the dosing device should be checked.
If animals are to be treated collectively rather than individually, they should be
grouped according to their bodyweight and dosed accordingly, in order to avoid
under- or over-dosing.
Cattle
Dosage:
1.0 ml per 50 kg bodyweight (based on a recommended dosage level of 200
micrograms ivermectin per kg bodyweight).
Administration:
Inject subcutaneously in front of, or behind, the shoulder using aseptic technique.
A sterile 1.4 x 15 mm (17G x ½ inch) needle is recommended.
SHEEP
Dosage:
0.5 ml per 25 kg of bodyweight (based on a recommended level of 200
micrograms ivermectin per kg bodyweight).
Administration:
For the treatment of gastrointestinal roundworms, lungworms and nasal bots inject
once subcutaneously in the neck, using aseptic precautions; a sterile 1.4 x 15 mm
(17G x ½ inch) needle is recommended. For the treatment of
(sheep scab), two injections with a seven day interval are required to treat clinical
signs of scab and to eliminate living mites.
For young lambs weighing less than 20.0 kg give 0.1 ml per 5 kg. In these lambs
the use of a syringe which can deliver as little as 0.1 ml is recommended.
Pigs
Dosage:
1.5 ml per 50 kg bodyweight (based on a recommended dosage level of 300
micrograms ivermectin per kg bodyweight)
Administration:
The recommended route of administration is by subcutaneous injection into the
neck using aseptic technique and a sterile 1.4 x 15 mm (17G x ½ inch) needle.
For piglets weighing less than 16 kg give 0.1 ml per 3 kg. In these piglets the use
of a syringe which can deliver as little as 0.1 ml is recommended.

Revised: October 2025
MA split from NI MA following AN: 01927/2025
When using the 200, 250 or 500ml pack sizes, use only automatic syringe
equipment. For the 50ml pack size, use of a multiple dose syringe is
recommended. To refill the syringe, use of a draw-off needle is recommended
to avoid excessive broaching of the stopper.
4.10 Overdose (symptoms, emergency procedures, antidotes), if necessary
Clinical symptoms of ivermectin toxicity include ataxia and depression. No
antidote has been identified. In case of overdose, symptomatic treatment should
be given. No signs of toxicity were observed in animals treated at up to 3 times
the recommended dose rate.
4.11 Withdrawal period(s)
Cattle:
Meat and offal: 49 days.
Do not use in lactating cows producing milk for human consumption. Do not use
in non-lactating dairy cows, including pregnant dairy heifers, within 60 days of
calving.
Sheep:
Meat and offal: 42 days.
Do not use in lactating ewes producing milk for human consumption. Do not use
in sheep which are intended to produce milk for human consumption within 60
days of lambing.
Pigs:
Meat and offal: 28 days
5.